Results 81 to 90 of about 902,528 (341)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Secluded dark matter in gauged B − L model

Journal of High Energy Physics, 2022
We consider the gauged B − L model which is extended with a secluded dark sector, comprising of two dark sector particles. In this framework the lightest Z $$ \mathcal{Z} $$ 2-odd particle is the dark matter candidate, having a feeble interaction with ...
Priyotosh Bandyopadhyay, Manimala Mitra, Rojalin Padhan, Abhishek Roy, Michael Spannowsky   +4 more
doaj   +1 more source

Search for Invisible Axion Dark Matter with the Axion Dark Matter Experiment. [PDF]

Physical Review Letters, 2018
This Letter reports the results from a haloscope search for dark matter axions with masses between 2.66 and 2.81  μeV. The search excludes the range of axion-photon couplings predicted by plausible models of the invisible axion.
N. Du, N. Force, R. Khatiwada, E. Lentz, R. Ottens, L. Rosenberg, G. Rybka, G. Carosi, N. Woollett, D. Bowring, A. Chou, A. Sonnenschein, W. Wester, C. Boutan, N. Oblath, R. Bradley, E. Daw, A. Dixit, J. Clarke, S. O'kelley, N. Crisosto, J. Gleason, S. Jois, P. Sikivie, I. Stern, N. Sullivan, D. Tanner, G. Hilton   +27 more
semanticscholar   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

(sub)GeV Dark Matter in the $U(1)_X$ Higgs Portal Model [PDF]

, 2022
Amir Ahmadzadeh Amiri, Bastián Díaz Sáez, Karim Ghorbani   +2 more
openalex   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Dissipational versus Dissipationless Galaxy Formation and the Dark Matter Content of Galaxies

, 2010
We examine two extreme models for the build-up of the stellar component of luminous elliptical galaxies. In one case, we assume the build-up of stars is dissipational, with centrally accreted gas radiating away its orbital and thermal energy; the dark ...
Abadi, Abadi, Bernardi, Bernardi, Bezanson, Bode, Bode, C. N. Lackner, Cappellari, Cooray, de Blok, Diemand, El-Zant, El-Zant, Fukushige, Gao, Gilmore, Gnedin, Gnedin, Gonzalez, Inada, J. P. Ostriker, Jardel, Jesseit, Johansson, Kazantzidis, Kuhlen, Lauer, Lin, Lin, Loeb, Milosavljević, Naab, Naab, Navarro, Navarro, Oh, Pahre, Pooley, Rhee, Romano-Díaz, Romano-Díaz, Sand, Schechter, Sersic, Simon, Spekkens, Subramanian, Swaters, Tonini, Tremaine, Treu, Treu, Valenzuela, van der Wel, van Dokkum, Vass, Weinberg, Woźniak   +58 more
core   +1 more source

The Connection Between Galaxies and Their Dark Matter Halos [PDF]

Annual Review of Astronomy and Astrophysics, 2018
In our modern understanding of galaxy formation, every galaxy forms within a dark matter halo. The formation and growth of galaxies over time is connected to the growth of the halos in which they form.
Risa Wechsler, J. Tinker
semanticscholar   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Search for WIMPs at future μ + μ + colliders

Journal of High Energy Physics
Weakly interacting massive particles (WIMPs) with electroweak charges, such as the wino and the Higgsino, stand out as natural candidates for dark matter in the universe. In this paper, we study the search for WIMPs at future multi-TeV μ + μ + colliders.
Hajime Fukuda, Takeo Moroi, Atsuya Niki, Shang-Fu Wei   +3 more
doaj   +1 more source