Results 81 to 90 of about 1,388,983 (287)

A Avaliação do Capital de Risco segundo a Teoria das Opções [PDF]

Neste trabalho pretendemos aplicar a moderna Teoria das Opções na valorização da participação de uma Sociedade de Capital de Risco numa empresa participada.
Paulo Saraiva
core  

Advancing pharmacometrics in Africa—Transition from capacity development toward job creation

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 407-419, March 2025.
Abstract Trained pharmacometricians remain scarce in Africa due to limited training opportunities, lack of a pharmaceutical product development ecosystem, and emigration to high‐income countries. The Applied Pharmacometrics Training (APT) fellowship program was established to address these gaps and specifically foster job creation for talent retention.
Goonaseelan (Colin) Pillai, Samer Mouksassi, Innocent G. Asiimwe, Craig R. Rayner, Steven Kern, Phumla Sinxadi, Paolo Denti, Eric Decloedt, Catriona Waitt, Bernhards R. Ogutu, Rik de Greef   +10 more
wiley   +1 more source

Lipid-encapsulated mRNA encoding an extended serum half-life interleukin-22 ameliorates metabolic disease in mice

Molecular Metabolism
Objective: Interleukin (IL)-22 is a potential therapeutic protein for the treatment of metabolic diseases such as obesity, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease due to its involvement in multiple cellular pathways ...
Susanna Canali, Alexander W. Fischer, Mychael Nguyen, Karl Anderson, Lorna Wu, Anne-Renee Graham, Chiaowen Joyce Hsiao, Chinmayi Bankar, Nancy Dussault, Veronica Ritchie, Meagan Goodridge, Todd Sparrow, Allison Pannoni, Sze-Wah Tse, Vivienne Woo, Kaitlin Klovdahl, Jared Iacovelli, Eric Huang   +17 more
doaj   +1 more source

RNA structure prediction: progress and perspective

, 2014
Many recent exciting discoveries have revealed the versatility of RNAs and their importance in a variety of cellular functions which are strongly coupled to RNA structures.
Shi, Ya-Zhou, Tan, Zhi-Jie, Wang, Feng-Hua, Wu, Yuan-Yan   +3 more
core   +1 more source

Valorization of Garcinia humilis Residues in Active Collagen/Starch Films for Biodegradable Packaging Applications

Packaging Technology and Science, EarlyView.
Residues from Garcinia humilis were used to obtain a phenolic‐rich extract (GHRE) and incorporated into collagen–starch films. The addition of GHRE improved antioxidant activity, thermal stability and elasticity, while reducing water vapour permeability.
Érica da Costa Monção, Cristiani Viegas Brandão Grisi, Rita de Cassia Andrade da Silva, Sanierlly da Paz do Nascimento, Priscila Santos Souza, Laís Chantelle de Lima, Angela Maria Tribuzy de Magalhães Cordeiro, Antonia Lucia de Souza   +7 more
wiley   +1 more source

Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines

Molecular Therapy: Nucleic Acids, 2019
mRNA vaccines have the potential to tackle many unmet medical needs that are unable to be addressed with conventional vaccine technologies. A potent and well-tolerated delivery technology is integral to fully realizing the potential of mRNA vaccines. Pre-
Kimberly J. Hassett, Kerry E. Benenato, Eric Jacquinet, Aisha Lee, Angela Woods, Olga Yuzhakov, Sunny Himansu, Jessica Deterling, Benjamin M. Geilich, Tatiana Ketova, Cosmin Mihai, Andy Lynn, Iain McFadyen, Melissa J. Moore, Joseph J. Senn, Matthew G. Stanton, Örn Almarsson, Giuseppe Ciaramella, Luis A. Brito   +18 more
doaj   +1 more source

Crossing the borders of governance [PDF]

, 2014
La gobernanza es presentada por áreas confusas e indefinidas que tienden a expandirse de una manera más o menos arbitraria en ausencia de estándares normativos estables y confiables.
Tucci, Antonio
core   +3 more sources

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Desafios a Moçambique: nação e narrativas pós-coloniais [PDF]

, 2013
A constituição mútua do Norte e do Sul e a natureza hierárquica das relações Norte-Sul permanecem cativas da persistência das relações capitalistas e imperiais.
Meneses, Maria Paula
core  

Cell Culture Substrate Variation Alters Extracellular Vesicle Biogenesis Without Affecting Non‐Coding Repeat RNA Profile

Small, EarlyView.
Cell culture biomechanical conditions influence extracellular vesicles (EVs) production in patient‐derived pancreatic adenocarcinoma (PDAC) cell lines. When grown in 3D conformation and in hydrogels with lower elasticity (0.5kPA), PDAC cells produce higher numbers of EVs, compared with cells grown in 2D on classic cell culture plastic.
Sara I. Veiga, Rebecca L. Porter, Berent Aldikacti, Uma K. Paithankar, Kate Calhoun, Eric Tai, Vishal Thapar, Jillian F. Wise, David T. Ting, Shannon L. Stott   +9 more
wiley   +1 more source