Results 171 to 180 of about 2,063,794 (297)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Rheological Properties and Modification Mechanism of Emulsified Asphalt Modified with Waterborne Epoxy/Polyurethan Composite. [PDF]

Materials (Basel)
Li M, He Z, Yu J, Yu L, Shen Z, Kong L.
europepmc   +1 more source

The modification mechanism and the effect of magnesium chloride on poly(vinyl alcohol) films. [PDF]

RSC Adv, 2019
Du W, Jiang L, Shi M, Yang Z, Zhang X.
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Research on the Performance and Modification Mechanism of Gutta-Percha-Modified Asphalt. [PDF]

Polymers (Basel)
Yan S, Cui S, Guo N, Chu Z, Zhang J, Yan S, Jin X.   +6 more
europepmc   +1 more source

[6π] Photocyclization to cis-Hexahydrocarbazol-4-ones: Substrate Modification, Mechanism, and Scope. [PDF]

J Org Chem, 2019
Modha SG, Pöthig A, Dreuw A, Bach T.
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Modification mechanism of Te and morphology evolution of primary Mg₂Si in an Al-20Mg₂Si alloy. [PDF]

Heliyon
Li C, Wang Z, Zhao Y, Du J, Ma Y, Li J, Sun F.   +6 more
europepmc   +1 more source

Study of the modification mechanism of heavy metal ions adsorbed by biomass-activated carbon doped with a solid nitrogen source. [PDF]

RSC Adv, 2019
Zheng W, Chen S, Liu H, Ma Y, Xu W.
europepmc   +1 more source