Results 91 to 100 of about 600,227 (293)

Plant-based protein modification strategies towards challenges

Journal of Agriculture and Food Research
The world faces many critical challenges in food supply, including burgeoning population growth, the looming specter of climate change, rampant land degradation, diminishing water resources, and unsustainable agricultural practices.
Gulsah Karabulut, Gulden Goksen, Amin Mousavi Khaneghah   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Novel protein modification strategies

, 2018
Site-directed mutagenesis allows the ready variation of proteinogenic amino acids; genetic code expansion permit the incorporation of a few more. The widespread use of these genetic techniques has caused a revolution in molecular biology. A crucial limitation of genetic techniques is the ‘ribosomal filter’, where an amino acid has to be processed by ...
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Structure designing, interface engineering, and application prospects for sodium‐ion inorganic solid electrolytes

InfoMat
All‐solid Na‐ion batteries (ASNIBs) present significant potential for integration into large‐scale energy storage systems, capitalizing on their abundant raw materials, exemplary safety, and high energy density.
Meng Wu, Hong Liu, Xiang Qi, Dabing Li, Chao Wang, Ce‐Wen Nan, Li‐Zhen Fan   +6 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Machine learning-powered, high-affinity modification strategies for aptamers

Acta Materia Medica
The binding affinity of aptamers to targets has a crucial role in the pharmaceutical and biosensing effects. Despite diverse post-systematic evolution of ligands by exponential enrichment (post-SELEX) modifications explored in aptamer optimization ...
Gubu Amu, Xin Yang, Hang Luo, Sifan Yu, Huarui Zhang, Yuan Tian, Yuanyuan Yu, Shijian Ding, Yufei Pan, Zefeng Chen, Yixin He, Yuan Ma, Baoting Zhang, Ge Zhang, YANG XIN   +14 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Caring for the carer: home design and modification for carers of young people with disability [PDF]

, 2014
This HMinfo Occasional Research Paper focuses on carers, that is those who deliver informal (unpaid) care to young people with disability, and particularly those carers who share their home with the person they are caring for, as well as the housing ...
Laura Davy, Toni Adams, Catherine Bridge
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