Results 261 to 270 of about 600,227 (293)

Strategies for disease modification in Alzheimer's disease

Nature Reviews Neuroscience, 2004
Treating Alzheimer's disease (AD) is the biggest unmet medical need in neurology. Current drugs improve symptoms, but do not have profound disease-modifying effects. Three main classes of disease-modification approaches can be defined: one that is broadly neurotrophic or neuroprotective, one that targets specific aspects of AD pathology, and one that ...
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Synthetic Strategies for the Modification of Diclofenac

Synlett, 2017
For many heterogeneous sensor applications as well as the synthesis of hapten antigens to produce antibodies, protein conjugates of the target substance are essential. A requirement is that the target substance already offers or is modified to contain a functionality that allows for coupling to a protein, that is, an amino acid residue.
Rudolf Schneider, Stephan Schmidt, Sven Hanelt, Carsten Canitz, Holger Hoffmann, Leif-Alexander Garbe   +5 more
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Advances in Modification Strategies of Polysaccharides and Their Applications

Journal of Food Science
ABSTRACT Natural polysaccharides are important biopolymers with unique physicochemical properties and promising biological activities, making them valuable for applications across the food, pharmaceutical, cosmeceutical, and packaging fields.
Yana Zhao, Mengdi Wang, He Li, Zhijun Zhang, Huizhen Li   +4 more
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Chemoselective Ligation and Modification Strategies for Peptides and Proteins

Angewandte Chemie International Edition, 2008
AbstractThe investigation of biological processes by chemical methods, commonly referred to as chemical biology, often requires chemical access to biologically relevant macromolecules such as peptides and proteins. Building upon solid‐phase peptide synthesis, investigations have focused on the development of chemoselective ligation and modification ...
Christian P R, Hackenberger, Dirk, Schwarzer   +1 more
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Iminoboronates: A New Strategy for Reversible Protein Modification

Journal of the American Chemical Society, 2012
Protein modification has entered the limelight of chemical and biological sciences, since, by appending small molecules into proteins surfaces, fundamental biological and biophysical processes may be studied and even modulated in a physiological context. Herein we present a new strategy to modify the lysine's ε-amino group and the protein's N-terminal,
Pedro M S D, Cal, João B, Vicente, Elisabete, Pires, Ana V, Coelho, Luís F, Veiros, Carlos, Cordeiro, Pedro M P, Gois   +6 more
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Strategies for cancer prevention through diet modification

Medical Oncology and Tumor Pharmacotherapy, 1990
Diet and cancer research at the National Cancer Institute has grown from a budget of $2.5 million in 1974 to $55 million in 1988. The emphasis is partially on demonstrations of prevention strategies and chemoprevention trials. Studies to disseminate dietary goals in practical ways are undertaken with the aid of the food industry.
P, Greenwald, L, Light, S S, McDonald, H R, Stern   +3 more
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Interactive eye tracking for gaze strategy modification

Proceedings of the 14th International Conference on Interaction Design and Children, 2015
Atypical looking behaviors in neuropsychiatric conditions such as autism spectrum disorders (ASD) are not only a reflection of inherently abnormal neuropsychological processes, but also suggest that future access to observational learning opportunities may be limited.
Quan Wang 0003, Feridun M. Celebi, Lilli Flink, Gabriella Greco, Carla A. Wall, Emily Prince, Sharlene Lansiquot, Katarzyna Chawarska, Elizabeth S. Kim, Laura Boccanfuso, Lauren DiNicola, Frédérick Shic   +11 more
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Strategies for genetic modification of Lactococci

Food Biotechnology, 1990
Abstract Lactococci are used for the manufacture of fermented dairy products. Many technological functions are coded on plasmids: lactose and citrate utilization, a cell wall associated protease, bacteriocin and slime production and phage insensitivity phenomena.
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Strategies for the Modification and Evaluation of Allergenicity

2015
Allergic disease is a global public health problem with increasing attention being paid to the evaluation and modification of allergenicity. The major aim of this chapter is to provide an overview of the field of allergenicity evaluation and modification focusing on bioinformatics evaluation, in vitro evaluation, and in vivo evaluation, which are the ...
Zhaoyu Liu, Huifang Chen, Ailin Tao
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Strategies for surface modification of gelatin-based nanoparticles

Colloids and Surfaces B: Biointerfaces, 2019
Recently developed methodologies related to surface modification of nanoparticles provide nano systems with the final properties required for a desired application. In nano-pharmaceutical field, the major goals of surface modification are to make nanoparticles unrecognizable by the immune system and to guide them to the desired site.
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