Results 111 to 120 of about 9,718,541 (278)

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Mechanical error estimation in four-bar hyperbolic function mechanisms with tolerances using modified PDA approach

Engineering Research Express
Abstract Four-bar mechanisms play a critical role in mechanical design, especially in function generation applications. They are commonly employed across a wide range of systems, from simple mechanical links to sophisticated biomedical devices.
Ankur Jaiswal, H P Jawale, Anil Kumar, Abhishek Jha, Umesh Kumar Sahu, Anand Solanki, Pawan Kumar Patnaik, Prasenjit Biswas   +7 more
openaire   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Deep Learning Function Implications For Handwritten Character Recognition Using Improved Mean Square Error Function

مجلة بغداد للعلوم
Loss functions are used for estimating the accuracy of the classification models in Machine Learning. The error loss value measures whether the predicted labels match the true labels or are close to them.
Bahera H. Nayef, Siti Norul Huda Sheikh Abdullah, Manal Mohammed   +2 more
doaj   +1 more source

A modified sulphide capacity function

, 1994
The sulphide capacity as originally defined by Fincham and Richardson is a strong function of composition in pseudobinary oxide melts of interest in extractive metallurgy.
Nilsson, R, Jacob, KT, Seetharaman, S
core  

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

A Power Log-logistic Modified Weibull Distribution: Model, Properties and a Simulation

مجلة بغداد للعلوم
This paper deals with a new model called the power log-logistic modified Weibull distribution (PLLoGMWD) using the power transformation method, which can be regarded as an extension of the distribution introduced by Broderick O. Oluyede et al.
Jumana A. Altawil
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Proposal of a Modified Loss Function with the Gaussian Copula Density Function to Improve LSTM Predictions of PM₁₀ and PM_2.5 Concentrations

Computers
Air pollution forecasting for Particulate Matter (PM10 and PM2.5) is a challenge for human health in order to improve the life quality of humans around the world.
Alejandro Mendoza-Ibarra, Marco Antonio Aceves-Fernandez, Juan Manuel Ramos-Arreguín, Artemio Sotomayor-Olmedo   +3 more
doaj   +1 more source