Results 71 to 80 of about 1,623,043 (289)

Dead-end filtration of natural organic matter: experimental evidence of critical conditions [PDF]

, 2005
The development of membrane technology has reached a state whereby operational optimisation is becoming the major issue to both researchers and industrial operators.
Jefferson, Bruce, Bessiere, Yolaine, Bacchin, Patrice   +2 more
core   +1 more source

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

SIRT1-modified human umbilical cord mesenchymal stem cells ameliorate experimental peritoneal fibrosis by inhibiting the TGF-β/Smad3 pathway

Stem Cell Research & Therapy, 2020
Introduction Peritoneal fibrosis is a serious complication of long-term peritoneal dialysis (PD). Combination therapies are emerging as a promising treatment for tissue damage.
Yanhong Guo, Liuwei Wang, Rong Gou, Yulin Wang, Xiujie Shi, Xinxin Pang, Lin Tang   +6 more
doaj   +1 more source

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source

Removal of prostaglandin E2 and increased intraoperative blood pressure during modified ultrafiltration in pediatric cardiac surgery [PDF]

, 2009
ObjectiveWe investigated the relationship between serum prostaglandin E2 and intraoperative blood pressure in pediatric cardiac surgery with modified ultrafiltration.MethodsIn 35 consecutive patients (31.6 ± 26.8 months, 0.4–111 months, 10.9 ± 5.5 kg, 2 ...
Yokoyama, Kazuto, Takabayashi, Shin, Shimpo, Hideto, Komada, Takuya, Iwata, Hideki, Mitani, Yoshihide, Onoda, Koji   +6 more
core   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

In vitro evaluation of critical ultrafiltration fluxes and transmembrane pressure in a high flux dialyzer

Scientific Reports
In patients treated with haemodiafiltration, high convection volumes are considered beneficial. However it leads to pressure instability and membrane fouling.
Siavash Sohan Gir, Nathalie Gayrard, Alain Ficheux, Jonas Laget, Chantal Cazevieille, Àngel Argilés, Flore Duranton   +6 more
doaj   +1 more source

A comparison of sequential total and activated white cell count in patients undergoing coronary artery bypass grafting, using cardiopulmonary bypass, with and without a white cell filter

, 1999
Introduction Cardiopulmonary bypass (CPB) has been shown to induce a systemic inflammatory response similar to the local reaction seen after tissue damage [1].
Sheppard, S.V., Smith, D.C., Kulkarni, M., Nanson, J.K.   +3 more
core   +1 more source

Radical‐Mediated In Situ Fluorescence Dye Deposition: A Simple Interfacial Signal Amplification Reaction for Ultrasensitive Immunoassay on Barcode Beads

Advanced Science, EarlyView.
A radical‐mediated in situ fluorescence dye deposition (RIFD) reaction containing merely three elements of beads, dyes, and radicals is discovered for the first time, and its underlying mechanism is elucidated. This simple RIFD enables the interfacial and ultrafast deposition of free dyes onto barcode beads, serving as a powerful signal amplification ...
Jiayu Zhang, Yao Wang, Xinyi Huang, Haiyu Wu, Qiuning Lin, Hongchen Gu, Li Jiang, Linyong Zhu, Hong Xu   +8 more
wiley   +1 more source

Laponite nanosheets modified polyethersulfone membranes with enhanced high-pressure resistance for stable separation

Advanced Membranes
Many high-performance ultrafiltration membranes have been developed to address pollutant removal in complex water environments. However, the permeability-selectivity trade-off and inherent instability issues remain unresolved.
Zhijiang Sun, Xianya Wu, Yumeng Wang, Yu Jiang, Tao Yao, Shengtao Niu, Jianzhou Niu, Dahui Wang, Zehua Yin, Fen Ran   +9 more
doaj   +1 more source