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Immunogenicity and Safety of Modified Vaccinia Ankara (MVA) Vaccine—A Systematic Review and Meta-Analysis of Randomized Controlled Trials [PDF]

Vaccines, 2023
Prevention of mpox has become an important public health interest. We aimed to evaluate the safety and immunogenicity of the Modified Vaccinia Ankara (MVA) vaccine. We conducted a systematic review and meta-analysis of randomized-controlled trials (RCTs)
Lior Nave, Ili Margalit, Noam Tau, Ido Cohen, Dana Yelin, Florian Lienert, Dafna Yahav   +6 more
doaj   +2 more sources

Transient Host Range Selection for Genetic Engineering of Modified Vaccinia Virus Ankara [PDF]

BioTechniques, 2000
Recombinant vaccinia viruses are extremely valuable tools for research in molecular biology and immunology. The extension of vaccinia vector technology to replication-deficient and safety-tested virus strains such as modified vaccinia virus Ankara (MVA ...
C. Staib, I. Drexler, M. Ohlmann, S. Wintersperger, V. Erfle, G. Sutter   +5 more
doaj   +2 more sources

Quantitative proteomics defines mechanisms of antiviral defence and cell death during modified vaccinia Ankara infection [PDF]

Nature Communications, 2023
Modified vaccinia Ankara (MVA) virus does not replicate in human cells and is the vaccine deployed to curb the current outbreak of mpox. Here, we conduct a multiplexed proteomic analysis to quantify >9000 cellular and ~80% of viral proteins throughout ...
Jonas D. Albarnaz, Joanne Kite, Marisa Oliveira, Hanqi Li, Ying Di, Maria H. Christensen, Joao A. Paulo, Robin Antrobus, Steven P. Gygi, Florian I. Schmidt, Edward L. Huttlin, Geoffrey L. Smith, Michael P. Weekes   +12 more
doaj   +2 more sources

Efficacy of the modified vaccinia Ankara virus vaccine and the replication-competent vaccine ACAM2000 in monkeypox prevention. [PDF]

Int Immunopharmacol, 2023
Kandeel M, Morsy MA, Abd El-Lateef HM, Marzok M, El-Beltagi HS, Al Khodair KM, Albokhadaim I, Venugopala KN.   +7 more
europepmc   +2 more sources

The Efficacy of Disinfection on Modified Vaccinia Ankara and African Swine Fever Virus in Various Forest Soil Types [PDF]

Viruses, 2021
African swine fever (ASF) has become a global threat to the pig industry and wild suids. Within Europe, including Germany, affected wild boar populations play a major role.
Franziska Tanneberger, Ahmed Abd El Wahed, Melina Fischer, Sandra Blome, Uwe Truyen   +4 more
doaj   +2 more sources

One- and Two-Dose Vaccinations With Modified Vaccinia Ankara-Bavarian Nordic Induce Durable B-Cell Memory Responses Comparable to Replicating Smallpox Vaccines. [PDF]

J Infect Dis, 2023
Ilchmann H, Samy N, Reichhardt D, Schmidt D, Powell JD, Meyer TPH, Silbernagl G, Nichols R, Weidenthaler H, De Moerlooze L, Chen L, Chaplin P.   +11 more
europepmc   +3 more sources

A Multi-Valent Hantavirus Vaccine Based on Recombinant Modified Vaccinia Ankara Reduces Viral Load in a Mouse Infection Model. [PDF]

Vaccines (Basel)
Aram M, Graham V, Kennedy E, Rayner E, Hewson R, Dowall S.   +5 more
europepmc   +3 more sources

Modified vaccinia Ankara vaccine expressing Marburg virus-like particles protects guinea pigs from lethal Marburg virus infection. [PDF]

NPJ Vaccines, 2020
Malherbe DC, Domi A, Hauser MJ, Meyer M, Gunn BM, Alter G, Bukreyev A, Guirakhoo F.   +7 more
europepmc   +3 more sources

Intratumoral virotherapy with 4-1BBL armed modified vaccinia Ankara eradicates solid tumors and promotes protective immune memory. [PDF]

J Immunother Cancer, 2021
Hinterberger M, Giessel R, Fiore G, Graebnitz F, Bathke B, Wennier S, Chaplin P, Melero I, Suter M, Lauterbach H, Berraondo P, Hochrein H, Medina-Echeverz J.   +12 more
europepmc   +3 more sources

A Randomized, Double-Blind, Placebo-Controlled Phase II Trial Investigating the Safety and Immunogenicity of Modified Vaccinia Ankara Smallpox Vaccine (MVA-BN®) in 56-80-Year-Old Subjects.

PLoS ONE, 2016
BackgroundModified Vaccinia Ankara MVA-BN® is a live, highly attenuated, viral vaccine under advanced development as a non-replicating smallpox vaccine.
Richard N Greenberg, Christine M Hay, Jack T Stapleton, Thomas C Marbury, Eva Wagner, Eva Kreitmeir, Siegfried Röesch, Alfred von Krempelhuber, Philip Young, Richard Nichols, Thomas P Meyer, Darja Schmidt, Josef Weigl, Garth Virgin, Nathaly Arndtz-Wiedemann, Paul Chaplin   +15 more
doaj   +2 more sources