Results 21 to 30 of about 7,431 (174)

Original encounter with antigen determines antigen-presenting cell imprinting of the quality of the immune response in mice. [PDF]

PLoS ONE, 2009
BACKGROUND:Obtaining a certain multi-functionality of cellular immunity for the control of infectious diseases is a burning question in immunology and in vaccine design.
Valérie Abadie, Olivia Bonduelle, Darragh Duffy, Christophe Parizot, Bernard Verrier, Béhazine Combadière   +5 more
doaj   +1 more source

Development of Modified Vaccinia Virus Ankara-Based Vaccines: Advantages and Applications

Vaccines, 2022
Modified vaccinia virus Ankara (MVA) is a promising viral vector for vaccine development. MVA is well studied and has been widely used for vaccination against smallpox in Germany.
Olga Vladimirovna Orlova, Dina Viktorovna Glazkova, Elena Vladimirovna Bogoslovskaya, German Alexandrovich Shipulin, Sergey Mikhailovich Yudin   +4 more
doaj   +1 more source

Elements in the Development of a Production Process for Modified Vaccinia Virus Ankara

Microorganisms, 2013
The production of several viral vaccines depends on chicken embryo fibroblasts or embryonated chicken eggs. To replace this logistically demanding substrate, we created continuous anatine suspension cell lines (CR and CR.pIX), developed chemically ...
Volker Sandig, Udo Reichl, Verena Lohr, Yvonne Genzel, Ingo Jordan   +4 more
doaj   +1 more source

Investigating the Effect of Encapsulation Processing Parameters on the Viability of Therapeutic Viruses in Electrospraying

Pharmaceutics, 2020
The ability of viruses to introduce genetic material into cells can be usefully exploited in a variety of therapies and also vaccination. Encapsulating viruses to limit inactivation by the immune system before reaching the desired target and allowing for
Tayo Sanders, Anita Milicic, Eleanor Stride   +2 more
doaj   +1 more source

Pre-clinical efficacy and safety of experimental vaccines based on non-replicating vaccinia vectors against yellow fever. [PDF]

PLoS ONE, 2011
BACKGROUND: Currently existing yellow fever (YF) vaccines are based on the live attenuated yellow fever virus 17D strain (YFV-17D). Although, a good safety profile was historically attributed to the 17D vaccine, serious adverse events have been reported,
Birgit Schäfer, Georg W Holzer, Alexandra Joachimsthaler, Sogue Coulibaly, Michael Schwendinger, Brian A Crowe, Thomas R Kreil, P Noel Barrett, Falko G Falkner   +8 more
doaj   +1 more source

A Monovalent and Trivalent MVA-Based Vaccine Completely Protects Mice Against Lethal Venezuelan, Western, and Eastern Equine Encephalitis Virus Aerosol Challenge

Frontiers in Immunology, 2021
Venezuelan, eastern and western equine encephalitis viruses (EEV) can cause severe disease of the central nervous system in humans, potentially leading to permanent damage or death.
Lisa Henning, Kathrin Endt, Robin Steigerwald, Michael Anderson, Ariane Volkmann   +4 more
doaj   +1 more source

Production and Immunogenicity of Soluble Plant-Produced HIV-1 Subtype C Envelope gp140 Immunogens

Frontiers in Plant Science, 2019
The development of effective vaccines is urgently needed to curb the spread of human immunodeficiency virus type 1 (HIV-1). A major focal point of current HIV vaccine research is the production of soluble envelope (Env) glycoproteins which reproduce the ...
Emmanuel Margolin, Emmanuel Margolin, Rosamund Chapman, Ann E. Meyers, Michiel T. van Diepen, Phindile Ximba, Phindile Ximba, Tandile Hermanus, Tandile Hermanus, Carol Crowther, Carol Crowther, Brandon Weber, Lynn Morris, Lynn Morris, Anna-Lise Williamson, Anna-Lise Williamson, Edward P. Rybicki, Edward P. Rybicki   +17 more
doaj   +1 more source

Monkeypox: a global health emergency

Frontiers in Microbiology, 2023
Over the past 2 years, the world has faced the impactful Coronavirus Disease-2019 (COVID-19) pandemic, with a visible shift in economy, medicine, and beyond.
Ruxandra Ilinca Stilpeanu, Ruxandra Ilinca Stilpeanu, Ana Maria Stercu, Ana Maria Stercu, Andreea Lucia Stancu, Antoanela Tanca, Antoanela Tanca, Octavian Bucur, Octavian Bucur, Octavian Bucur   +9 more
doaj   +1 more source

Cardiac safety of Modified Vaccinia Ankara for vaccination against smallpox in a young, healthy study population. [PDF]

PLoS ONE, 2015
BACKGROUND:Conventional smallpox vaccines based on replicating vaccinia virus (VV) strains (e.g. Lister Elstree, NYCBOH) are associated with a high incidence of myo-/pericarditis, a severe inflammatory cardiac complication.
Eva-Maria Zitzmann-Roth, Frank von Sonnenburg, Stephan de la Motte, Nathaly Arndtz-Wiedemann, Alfred von Krempelhuber, Nadine Uebler, Jens Vollmar, Garth Virgin, Paul Chaplin   +8 more
doaj   +1 more source

Short- and Long-Interval Prime-Boost Vaccination with the Candidate Vaccines MVA-SARS-2-ST and MVA-SARS-2-S Induces Comparable Humoral and Cell-Mediated Immunity in Mice

Viruses, 2023
The COVID-19 pandemic caused significant human health and economic consequences. Due to the ability of SARS-CoV-2 to spread rapidly and to cause severe disease and mortality in certain population groups, vaccines are essential for controlling the ...
Georgia Kalodimou, Sylvia Jany, Astrid Freudenstein, Jan Hendrik Schwarz, Leonard Limpinsel, Cornelius Rohde, Alexandra Kupke, Stephan Becker, Asisa Volz, Alina Tscherne, Gerd Sutter   +10 more
doaj   +1 more source