Results 41 to 50 of about 7,431 (174)

Plasmablast, Memory B Cell, CD4+ T Cell, and Circulating Follicular Helper T Cell Responses to a Non-Replicating Modified Vaccinia Ankara Vaccine

Vaccines, 2020
Background: Vaccinia is known to induce antibody and cellular responses. Plasmablast, circulating follicular helper T (cTFH) cells, cytokine-expressing CD4 T cells, and memory B cells were compared between subcutaneous (SC) and needle-free jet injection (
Evan J. Anderson, Lilin Lai, Jens Wrammert, Sarah Kabbani, Yongxian Xu, Lalita Priyamvada, Heather Hill, Johannes B. Goll, Travis L. Jensen, Carol Kao, Inci Yildirim, Nadine Rouphael, Lisa Jackson, Mark J. Mulligan   +13 more
doaj   +1 more source

Sex Differences in Response to Viral Vector Vaccines—Implications for Future Vaccine Design

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Vaccination represents one of the most impactful public health achievements, preventing 3.5 to 5 million deaths annually according to estimates of the World Health Organization. Yet, recent outbreaks of emerging and reemerging infectious diseases highlight the need for rapid and strategic vaccine development using vaccine platforms ...
Ilka Grewe, Tamara Zoran, Marylyn Martina Addo   +2 more
wiley   +1 more source

Genome Sequencing of a Camelpox Vaccine Reveals Close Similarity to Modified Vaccinia virus Ankara (MVA)

Viruses, 2020
Camelpox is a viral contagious disease of Old-World camelids sustained by Camelpox virus (CMLV). The disease is characterized by mild, local skin or severe systemic infections and may have a major economic impact due to significant losses in terms of ...
Maurilia Marcacci, Abdelmalik I. Khalafalla, Zulaikha M. Al Hammadi, Federica Monaco, Cesare Cammà, Mohammed F. Yusof, Saeed M. Al Yammahi, Iolanda Mangone, Fabrizia Valleriani, Mohamed A. Alhosani, Nicola Decaro, Alessio Lorusso, Salama S. Almuhairi, Giovanni Savini   +13 more
doaj   +1 more source

Monkeypox Virus: Epidemiology, Virology, Diagnosis, Vaccine, and Therapeutics

MedComm, Volume 7, Issue 1, January 2026.
This review provides a comprehensive overview of the latest research advances in MPXV, with a focused analysis across five core dimensions: epidemiology, virology, diagnosis, vaccine, and therapeutics. The primary objective of this review is to advance the understanding of MPXV and facilitate the development of more effective diagnostic methods ...
Yunzheng Yan, Yaqin Sun, Guangyan Sun, Cheng Niu, Xinyuan Zhao, Ming Zhao, Tongyao Liu, Suyue Zhang, Hui Zhai, Ankang Liu, Shouzhi Yu, Shuyuan Pan, Wu Zhong, Yuntao Zhang, Song Li   +14 more
wiley   +1 more source

The Impact of Monkeypox Virus Infection on Pregnancy Outcome: Clinical Features and Potential Pathogenic Mechanisms

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Monkeypox has garnered significant attention following its emergence in multiple countries and its designation as a global health emergency in 2022. There is a notable deficiency in clinical and experimental data regarding pregnancy outcomes following monkeypox infection.
Jingyi Wu, Fangbin Huang, Qingliang Zheng, Poorani Gurumallesh   +3 more
wiley   +1 more source

Synergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosis

OncoImmunology, 2022
Recombinant-modified vaccinia virus Ankara (rMVA) is known to elicit potent antitumor immune responses in preclinical models due to its inherent ability to activate the innate immune system and the activation of adaptive responses mediated by the ...
Ángela Bella, Leire Arrizabalaga, Claudia Augusta Di Trani, Assunta Cirella, Myriam Fernandez-Sendin, Celia Gomar, Joan Salvador Russo-Cabrera, Inmaculada Rodríguez, José González-Gomariz, Maite Alvarez, Álvaro Teijeira, José Medina-Echeverz, Maria Hinterberger, Hubertus Hochrein, Ignacio Melero, Pedro Berraondo, Fernando Aranda   +16 more
doaj   +1 more source

Harvesting AAV by tangential flow filtration using reverse asymmetric membranes

Biotechnology Progress, Volume 41, Issue 6, November/December 2025.
Abstract Efficient bioreactor clarification for harvesting virus particles is often challenging. Tangential flow filtration is attractive as it can be easily adapted for batch and perfusion operations. Here the feasibility of using reverse asymmetric hollow fiber membranes, where the more open support structure faces the feed stream, has been ...
Xiaolei Hao, Ronny Horax, Xianghong Qian, April Wheeler, Hironobu Shirataki, S. Ranil Wickramasinghe   +5 more
wiley   +1 more source

Protective CD8+ T cell responses against the pre-erythrocytic stages of malaria parasites: an overview

Memorias do Instituto Oswaldo Cruz, 2001
CD8+ T cells have been implicated as critical effector cells in protection against the pre-erythrocytic stage of malaria in mice and humans following irradiated sporozoite immunization.
J Oliveira-Ferreira, CT Daniel-Ribeiro
doaj   +1 more source

Recent Advancements in Known and Emerging Risk Factors of Hepatocellular Carcinoma

Cancer Medicine, Volume 14, Issue 21, November 2025.
ABSTRACT Background Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and a leading cause of cancer‐related deaths worldwide. Despite advancements in antiviral therapies for hepatitis B (HBV) and hepatitis C (HCV), HCC incidence continues to rise due to metabolic dysfunction‐associated steatotic liver disease (MASLD), obesity ...
Muhammad Masroor Hussain, Bi Feng, Ju‐Mei Wang, Ao‐Qiang Zhai, Fu‐yu Li, Hai‐jie Hu   +5 more
wiley   +1 more source

Replication-incompetent viral vaccine vectors ChAdOx1 and MVA as tools for evaluating T-cell responses to naturally processed antigens in vitro

Virus Research
Assessing T-cell responses is critical for vaccine development. In vitro methods using SARS-CoV-2 or recombinant vaccinia virus with B cells effectively activate T-cells but require stringent biosafety conditions.
Salik Nazki, Jesús Reiné, Reshma Kailath, Sarah Gilbert, Bruno Douradinha   +4 more
doaj   +1 more source