Results 51 to 60 of about 7,431 (174)

A Multicenter, Open-Label, Controlled Phase II Study to Evaluate Safety and Immunogenicity of MVA Smallpox Vaccine (IMVAMUNE) in 18-40 Year Old Subjects with Diagnosed Atopic Dermatitis.

PLoS ONE, 2015
BackgroundReplicating smallpox vaccines can cause severe complications in individuals with atopic dermatitis (AD). Prior studies evaluating Modified Vaccinia Ankara virus (MVA), a non-replicating vaccine in humans, showed a favorable safety and ...
Richard N Greenberg, Maria Yadira Hurley, Dinh V Dinh, Serena Mraz, Javier Gomez Vera, Dorothea von Bredow, Alfred von Krempelhuber, Siegfried Roesch, Garth Virgin, Nathaly Arndtz-Wiedemann, Thomas Peter Meyer, Darja Schmidt, Richard Nichols, Philip Young, Paul Chaplin   +14 more
doaj   +1 more source

Short-Lived Neutralizing Antibody Responses to Monkeypox Virus in Smallpox Vaccine–Naive Persons after JYNNEOS Vaccination

Emerging Infectious Diseases
JYNNEOS, a third-generation smallpox vaccine, is integral to monkeypox virus (MPXV) control efforts, but the durability of this modified vaccinia Ankara–Bavarian Nordic (MVA-BN) vaccine’s effectiveness is undefined.
Kara Phipps, Jennifer Yates, Jessica Pettit, Sean Bialosuknia, Danielle Hunt, Alan P. DuPuis, Anne Payne, William Lee, Kathleen A. McDonough   +8 more
doaj   +1 more source

Comparison of Safety and Vector-Specific Immune Responses in Healthy and HIV-Infected Populations Vaccinated with MVA-B

Vaccines, 2019
There are few studies comparing the safety and immunogenicity of the same HIV immunogen in healthy volunteers and HIV-infected individuals. We analyzed demographics, adverse events (AEs), and immunogenicity against vaccinia virus in preventive (RISVAC02,
Elvira Couto, Vicenç Diaz-Brito, Beatriz Mothe, Alberto C. Guardo, Irene Fernandez, Ainoa Ugarte, Flor Etcheverry, Carmen E. Gómez, Mariano Esteban, Judit Pich, Joan Albert Arnaiz, Juan Carlos López Bernaldo de Quirós, Christian Brander, Montserrat Plana, Felipe García, Lorna Leal   +15 more
doaj   +1 more source

Humoral and functional SARS‐CoV‐2‐specific T‐cell responses elicited in chronic lymphocytic leukaemia patients with GEO‐CM04S1 a synthetic MVA‐vectored COVID‐19 vaccine

British Journal of Haematology, EarlyView.
Sandra Ortega‐Francisco, Maria Teresa Prudente de Aquino, Corinna La Rosa, Flavia Chiuppesi, Miguel‐Angel Gutierrez, Jacqueline Miller, Jing Li, Jada Mack‐Onyeike, Yifei Zhou, Qiao Zhou, Teodora Kaltcheva, Angela Patterson, Shannon Dempsey, Sandra Thomas, Katrin Tiemann, Dongyun Yang, Wasima Rida, Felix Wussow, Kelly McKee, Randy Taplitz, Erica Raiden, Tanya Siddiqi, Steven Rosen, Don J. Diamond, Alexey Danilov   +24 more
wiley   +1 more source

Plasmacytoid and CD141+ Myeloid Dendritic Cells Cooperation with CD8+ T Cells in Lymph Nodes is Associated with HIV Control

MedComm, Volume 6, Issue 9, September 2025.
Plasmacytoid and CD141+ myeloid dendritic cells cooperate with CD8+ T cells in lymph nodes, which is associated with HIV levels in blood and tissue. The interaction with primed dendritic cells with Toll‐like receptor agonists increase HIV‐specific CD8+ T cell response and PD‐1 blocking further enhance this response.
Joana Vitallé, Sara Bachiller, Beatriz Dominguez‐Molina, Eirini Moysi, Sara Ferrando‐Martínez, María Inés Camacho‐Sojo, Isabel Gallego, Alberto Pérez‐Gómez, María Reyes Jiménez‐Leon, Carmen Gasca‐Capote, Francisco José Ostos, Mohammed Rafii‐El‐Idrissi Benhnia, Laura E. Via, Antonio Mochón, Luis Fernando López‐Cortes, Constantinos Petrovas, Richard A. Koup, Ezequiel Ruiz‐Mateos   +17 more
wiley   +1 more source

The Role of Public Health Interventions and Control Measures During Mpox Outbreaks: Enhancing Strategies for Disease Prevention and Management

Public Health Challenges, Volume 4, Issue 3, September 2025.
This paper highlights key public health interventions and control strategies implemented during mpox outbreaks, emphasizing early detection, targeted prevention, and the role of vaccination and education in mitigating disease transmission. ABSTRACT Mpox (formerly—monkeypox) is the second viral pit break after COVID‐19.
Muhammad Shaheer Bin Faheem, Ahmed Ali Khan, Qasra Faheem, Hafiza Qurat Ul Ain, Wajiha Imam, Yusra Aimen, Raheel Ahmed   +6 more
wiley   +1 more source

Role of Fibroblast‐Immune Crosstalk in Kidney, Lung, and Skin Tertiary Lymphoid Structures

Immunological Reviews, Volume 334, Issue 1, September 2025.
ABSTRACT Tertiary lymphoid structures (TLSs) are organized aggregates of lymphocytes, myeloid cells, and stromal cells that form at sites of inflammation, providing adaptive immune responses outside of secondary lymphoid organs (SLOs). Found in various pathological conditions—including chronic infections, cancer, organ transplantation, autoimmune ...
Amy Cross, Jennifer Shelley, Rebecca Newman, Jessica Strid, Alice E. Denton   +4 more
wiley   +1 more source

Modulation of Cell Surface Receptor Expression by Modified Vaccinia Virus Ankara in Leukocytes of Healthy and HIV-Infected Individuals

Frontiers in Immunology, 2020
Viral vectors are increasingly used as delivery means to induce a specific immunity in humans and animals. However, they also impact the immune system, and it depends on the given context whether this is beneficial or not.
Adrien Leite Pereira, Quentin Jouhault, Ernesto Marcos Lopez, Antonio Cosma, Olivier Lambotte, Olivier Lambotte, Olivier Lambotte, Roger Le Grand, Michael H. Lehmann, Nicolas Tchitchek   +9 more
doaj   +1 more source

Comparative pathogenicity of vaccinia virus and mpox virus infections in CAST/EiJ mice: Exploring splenomegaly and transcriptomic profiles

Animal Models and Experimental Medicine, Volume 8, Issue 8, Page 1376-1386, August 2025.
We successfully constructed CAST/EiJ mice models infected with low‐dose vaccinia virus (VACV‐L), high‐dose VACV (VACV‐H), and mpox virus (MPXV), demonstrating that VACV‐L and MPXV infections induced splenomegaly in mice, and VACV‐H infection caused mortality in mice.
Yongzhi Hou, Jianrong Ma, Baoying Huang, Na Li, Lin Zhu, Ziqing Jia, Jiasen Yang, Jingjing Zhang, Wenjie Tan, Jing Xue   +9 more
wiley   +1 more source

Vaccination in dermatology 2025: Update considering current recommendations of the German Standing Committee on Vaccination

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 23, Issue 8, Page 925-930, August 2025.
Summary The immunosuppressive and immunomodulatory treatment of dermatological patients necessitates the regular review and updating of standard vaccinations and vaccines indicated for specific conditions. The German Standing Committee on Vaccination (STIKO) at the Robert Koch Institute regularly publishes evidence‐based vaccination recommendations ...
Johanna Stoevesandt, Marc Schmalzing, Sophia Mohme, Matthias Goebeler   +3 more
wiley   +1 more source