Development of Modified Vaccinia Virus Ankara-Based Vaccines: Advantages and Applications [PDF]
Vaccines, 2022 Modified vaccinia virus Ankara (MVA) is a promising viral vector for vaccine development. MVA is well studied and has been widely used for vaccination against smallpox in Germany.
Olga Vladimirovna Orlova +4 more
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Modified Vaccinia Virus Ankara as a Viral Vector for Vaccine Candidates against Chikungunya Virus [PDF]
Biomedicines, 2021 There is a need to develop a highly effective vaccine against the emerging chikungunya virus (CHIKV), a mosquito-borne Alphavirus that causes severe disease in humans consisting of acute febrile illness, followed by chronic debilitating polyarthralgia ...
Juan García-Arriaza +2 more
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Protective CD8+ T Cell Response Induced by Modified Vaccinia Virus Ankara Delivering Ebola Virus Nucleoprotein [PDF]
Vaccines, 2022 The urgent need for vaccines against Ebola virus (EBOV) was underscored by the large outbreak in West Africa (2014–2016). Since then, several promising vaccine candidates have been tested in pre-clinical and clinical studies.
Alexandra Kupke +13 more
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A recombinant Modified Vaccinia virus Ankara expressing prME of tick-borne encephalitis virus affords mice full protection against TBEV infection [PDF]
Frontiers in Immunology, 2023 IntroductionTick-borne encephalitis virus (TBEV) is an important human pathogen that can cause a serious disease involving the central nervous system (tick-borne encephalitis, TBE).
Mareike Kubinski +15 more
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Genome Sequencing of a Camelpox Vaccine Reveals Close Similarity to Modified Vaccinia virus Ankara (MVA) [PDF]
Viruses, 2020 Camelpox is a viral contagious disease of Old-World camelids sustained by Camelpox virus (CMLV). The disease is characterized by mild, local skin or severe systemic infections and may have a major economic impact due to significant losses in terms of ...
Maurilia Marcacci +13 more
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Modulation of Cell Surface Receptor Expression by Modified Vaccinia Virus Ankara in Leukocytes of Healthy and HIV-Infected Individuals [PDF]
Frontiers in Immunology, 2020 Viral vectors are increasingly used as delivery means to induce a specific immunity in humans and animals. However, they also impact the immune system, and it depends on the given context whether this is beneficial or not.
Adrien Leite Pereira +9 more
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Stability of the HSV-2 US-6 Gene in the del II, del III, CP77, and I8R-G1L Sites in Modified Vaccinia Virus Ankara After Serial Passage of Recombinant Vectors in Cells [PDF]
Vaccines, 2020 The modified vaccinia virus Ankara (MVA), a severely attenuated strain of vaccinia virus, is a promising vector platform for viral-vectored vaccine development because of its attributes of efficient transgene expression and safety profile, among others ...
Vajini N. Atukorale +2 more
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Zinc-finger antiviral protein (ZAP) is a restriction factor for replication of modified vaccinia virus Ankara (MVA) in human cells. [PDF]
PLoS Pathogens, 2020 Modified vaccinia virus Ankara (MVA) is an approved smallpox vaccine and a promising vaccine vector for other pathogens as well as for cancer therapeutics with more than 200 current or completed clinical trials.
Chen Peng +5 more
doaj +2 more sources
Hazard Characterization of Modified Vaccinia Virus Ankara Vector: What Are the Knowledge Gaps? [PDF]
Viruses, 2017 Modified vaccinia virus Ankara (MVA) is the vector of choice for human and veterinary applications due to its strong safety profile and immunogenicity in vivo.
Malachy I. Okeke +7 more
doaj +2 more sources
Vaccines, 2023 Prevention of mpox has become an important public health interest. We aimed to evaluate the safety and immunogenicity of the Modified Vaccinia Ankara (MVA) vaccine. We conducted a systematic review and meta-analysis of randomized-controlled trials (RCTs)
Lior Nave +6 more
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