Non-plaque-forming virions of Modified Vaccinia virus Ankara express viral genes
In cell culture infections with vaccinia virus the number of counted virus particles is substantially higher than the number of plaques obtained by titration. We found that standard vaccine preparations of recombinant Modified Vaccinia virus Ankara produce only about 20-30% plaque-forming virions in fully permissive cell cultures.
Anna-Theresa Lülf+4 more
openaire +3 more sources
The immunogenicity of recombinant modified vaccinia Ankara, a highly attenuated vaccinia virus, expressing influenza nucleoprotein (MVA-NP) and HIV-1 gag (MVA-gag) was investigated. Restimulation of peripheral blood lymphocytes of healthy subjects with MVA-NP led to expansion of CTL with specificity for known NP epitopes. These CTL efficiently lysed NP
Dorrell, L.+7 more
openaire +5 more sources
Induction of AIDS Virus-Specific CTL Activity in Fresh, Unstimulated Peripheral Blood Lymphocytes from Rhesus Macaques Vaccinated with a DNA Prime/Modified Vaccinia Virus Ankara Boost Regimen [PDF]
Todd M. Allen+13 more
openalex +1 more source
Recombinant Modified Vaccinia Virus Ankara Expressing the Surface gp120 of Simian Immunodeficiency Virus (SIV) Primes for a Rapid Neutralizing Antibody Response to SIV Infection in Macaques [PDF]
Ilnour Ourmanov+3 more
openalex +1 more source
Comparative Efficacy of Recombinant Modified Vaccinia Virus Ankara Expressing Simian Immunodeficiency Virus (SIV) Gag-Pol and/or Env in Macaques Challenged with Pathogenic SIV [PDF]
Ilnour Ourmanov+8 more
openalex +1 more source
Transduction of human dendritic cells with a recombinant modified vaccinia Ankara virus encoding MUC1 and IL-2 [PDF]
Katrina T. Trevor+4 more
openalex +1 more source
Intraperitoneal administration of a modified vaccinia virus Ankara confers single-chain interleukin-12 expression to the omentum and achieves immune-mediated efficacy against peritoneal carcinomatosis. [PDF]
Bella Á+17 more
europepmc +1 more source
Prime‐Boost Immunization with DNA and Modified Vaccinia Virus Ankara Vectors Expressing Herpes Simplex Virus–2 Glycoprotein D Elicits Greater Specific Antibody and Cytokine Responses than DNA Vaccine Alone [PDF]
Clement A. Meseda+3 more
openalex +1 more source
Recombinant viruses as tools to induce protective cellular immunity against infectious diseases [PDF]
Infections by intracellular pathogens such as viruses, some bacteria and many parasites, are cleared in most cases after activation of specific T cellular immune responses that recognize foreign antigens and eliminate infected cells.
Alexandre Vieira Machado+3 more
core +2 more sources