Results 31 to 40 of about 11,489 (193)

Shaping the tumor microenvironment with Modified Vaccinia Virus Ankara and TLR9 ligand [PDF]

OncoImmunology, 2015
Our preclinical data demonstrate that an intravenous injection of Modified Vaccinia virus Ankara induces CD8+ lymphocytes to infiltrate organs to control the growth of orthotopic renal carcinoma upon combination with a toll-like receptor 9 agonist.
Xavier Préville, Laetitia Fend, Karola Rittner   +2 more
openaire   +3 more sources

Heterologous prime-boost-boost immunisation of Chinese cynomolgus macaques using DNA and recombinant poxvirus vectors expressing HIV-1 virus-like particles [PDF]

, 2011
Background: There is renewed interest in the development of poxvirus vector-based HIV vaccines due to the protective effect observed with repeated recombinant canarypox priming with gp120 boosting in the recent Thai placebo-controlled trial.
Anson, Donald S., Blanchard, Thomas, Blanchard, Tom J., Bridge, Simon H., Dennis, Mike J., Dowall, Stuart D., Getty, Brian, Sharpe, Sally A., Skinner, Michael A., Stewart, James P.   +9 more
core   +4 more sources

Genomic sequence of chorioallantois vaccinia virus Ankara, the ancestor of modified vaccinia virus Ankara

Journal of General Virology, 2007
Chorioallantois vaccinia virus Ankara (CVA) is the parental virus of modified vaccinia virus Ankara (MVA), which was derived from CVA by more than 570 passages in chicken embryo fibroblasts (CEF). MVA became severely host-cell-restricted to avian cells and has strongly diminished virulence in mammalian hosts, while maintaining good immunogenicity.
Meisinger-Henschel, Christine, Schmidt, Michaela, Lukassen, Susanne, Linke, Burkhard, Krause, Lutz, Konietzny, Sebastian, Goesmann, Alexander, Howley, Paul, Chaplin, Paul, Suter, Mark, Hausmann, Juergen   +10 more
openaire   +5 more sources

Immunogenicity and safety of three consecutive production lots of the non replicating smallpox vaccine MVA: A randomised, double blind, placebo controlled phase III trial [PDF]

, 2018
BackgroundModified Vaccinia Ankara (MVA) is a live, viral vaccine under advanced development as a non-replicating smallpox vaccine. A randomised, double-blind, placebo-controlled phase III clinical trial was conducted to demonstrate the humoral ...
Chaplin, Paul, De Carli, Sonja, Kreusel, Christian, Lawrence, Steven J, Meyer, Thomas P, Nopora, Katrin, Overton, Edgar Turner, Rosch, Siegfried, Samy, Nathaly, Schnidt, Darja, Wagner, Eva, Weidenthaler, Heinz, Young, Philip   +12 more
core   +3 more sources

An intact signal peptide on dengue virus E protein enhances immunogenicity for CD8+ T cells and antibody when expressed from modified vaccinia Ankara [PDF]

, 2014
Dengue is a global public health concern and this is aggravated by a lack of vaccines or antiviral therapies. Despite the well-known role of CD8(+) T cells in the immunopathogenesis of Dengue virus (DENV), only recent studies have highlighted the ...
Coelho, Fabiana M., da Fonseca, Flávio G., Flesch, Inge E. A., Pinho, Tânia M. G., Quinan, Bárbara R., Tscharke, David C.   +5 more
core   +1 more source

Purification of modified vaccinia virus Ankara from suspension cell culture [PDF]

BMC Proceedings, 2015
Background A spectrum of viral vaccines, including the annual 620 million doses of trivalent influenza vaccines, are being produced in embryonated eggs of pharmaceutical quality, or with primary cells derived from such eggs [1,2]. Regulatory guidelines and experience for these processes are established and proven against time for 75 years [1]. However,
Diana Weimer, Ingo Jordan, Volker Sandig, Stefan Iarusso, Verena Lohr, Holger Bernhardt   +5 more
openaire   +2 more sources

Does limited virucidal activity of biocides include duck hepatitis B virucidal action? [PDF]

, 2012
BACKGROUND: There is agreement that the infectivity assay with the duck hepatitis B virus (DHBV) is a suitable surrogate test to validate disinfectants for hepatitis B virucidal activity.
Bust, Uwe, Glück, Brigitte, Rabenau, Holger, Sauerbrei, Andreas, Schacke, Michael, Wutzler, Peter   +5 more
core   +1 more source

Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity [PDF]

, 2013
Virus infection of mammalian cells is sensed by pattern recognition receptors and leads to an innate immune response that restricts virus replication and induces adaptive immunity.
Benfield, C T O, De Motes, C M, Ember, S W J, Ferguson, B J, Mazzon, M, Smith, G L, Sumner, R P   +6 more
core   +1 more source

Population, sexual and reproductive health, rights and sustainable development: forging a common agenda. [PDF]

, 2010
This article suggests that sexual and reproductive health and rights activists seeking to influence the post-2015 international development paradigm must work with sustainable development advocates concerned with a range of issues, including climate ...
Campbell, D. M., Carter, P. E., Collins-Emerson, J. M., French, N. P., Hathaway, S., Marshall, J., Midwinter, A. C., Mullner, P., Pirie, R., Shadbolt, T., Spencer, Simon E. F., Wilson, D. J.   +11 more
core   +1 more source

Induction of Influenza (H5N8) Antibodies by Modified Vaccinia Virus Ankara H5N1 Vaccine [PDF]

Emerging Infectious Diseases, 2015
To the Editor: Aquatic birds form a natural reservoir of avian influenza viruses from which new human and animal influenza viruses originate. After initial detection in 2010 in China, a new highly pathogenic avian influenza (HPAI) virus of the H5N8 subtype reemerged in ducks in South Korea in 2014 (1,2).
Joost H. C. M. Kreijtz, Rory D. de Vries, Albert D. M. E. Osterhaus, Guus F. Rimmelzwaan, Gerd Sutter, Heidi L. M. De Gruyter, Theo M. Bestebroer, Mark Pronk, Ron A. M. Fouchier   +8 more
openaire   +4 more sources