Results 31 to 40 of about 12,579 (242)

Vaccinia E5 is a major inhibitor of the DNA sensor cGAS

Nature Communications, 2023
The DNA sensor cyclic GMP-AMP synthase (cGAS) is critical in host antiviral immunity. Vaccinia virus (VACV) is a large cytoplasmic DNA virus that belongs to the poxvirus family.
Ning Yang, Yi Wang, Peihong Dai, Tuo Li, Christian Zierhut, Adrian Tan, Tuo Zhang, Jenny Zhaoying Xiang, Alban Ordureau, Hironori Funabiki, Zhijian Chen, Liang Deng   +11 more
doaj   +1 more source

Developing a Feline Immunodeficiency Virus Subtype B Vaccine Prototype Using a Recombinant MVA Vector

Vaccines, 2022
The feline immunodeficiency virus (FIV) is a retrovirus with global impact and distribution, affecting both domestic and wild cats. This virus can cause severe and progressive immunosuppression culminating in the death of felids.
Luis A. F. Andrade, Alice F. Versiani, Edel F. Barbosa-Stancioli, Jenner K. P. dos Reis, Jordana Grazziela A. C. dos Reis, Flavio G. da Fonseca   +5 more
doaj   +1 more source

Attenuation and immunogenicity of host-range extended modified vaccinia virus Ankara recombinants [PDF]

Vaccine, 2013
Modified vaccinia virus Ankara (MVA) is being widely investigated as a safe smallpox vaccine and as an expression vector to produce vaccines against other infectious diseases and cancer. MVA was isolated following more than 500 passages in chick embryo fibroblasts and suffered several major deletions and numerous small mutations resulting in ...
Sharon Melamed, Linda S. Wyatt, Robin J. Kastenmayer, Bernard Moss   +3 more
openalex   +3 more sources

Single Immunization of a Vaccine Vectored by a Novel Recombinant Vaccinia Virus Affords Effective Protection Against Respiratory Syncytial Virus Infection in Cotton Rats

Frontiers in Immunology, 2021
Respiratory syncytial virus (RSV) is a leading cause of respiratory infections worldwide and disease management measures are hampered by the lack of a safe and effective vaccine against the infection.
Marsha S. Russell, Sathya N. Thulasi Raman, Caroline Gravel, Wanyue Zhang, Wanyue Zhang, Annabelle Pfeifle, Annabelle Pfeifle, Wangxue Chen, Gary Van Domselaar, David Safronetz, Michael Johnston, Michael Johnston, Simon Sauve, Lisheng Wang, Michael Rosu-Myles, Michael Rosu-Myles, Jingxin Cao, Xuguang Li, Xuguang Li   +18 more
doaj   +1 more source

MERS-CoV‒Specific T-Cell Responses in Camels after Single MVA-MERS-S Vaccination

Emerging Infectious Diseases, 2023
We developed an ELISPOT assay for evaluating Middle East respiratory syndrome coronavirus (MERS-CoV)‒specific T-cell responses in dromedary camels. After single modified vaccinia virus Ankara-MERS-S vaccination, seropositive camels showed increased ...
Christian Meyer zu Natrup, Lisa-Marie Schünemann, Giulietta Saletti, Sabrina Clever, Vanessa Herder, Sunitha Joseph, Marina Rodriguez, Ulrich Wernery, Gerd Sutter, Asisa Volz   +9 more
doaj   +1 more source

Recombinant modified vaccinia virus Ankara-based malaria vaccines. [PDF]

Expert Rev Vaccines, 2016
A safe and effective malaria vaccine is a crucial part of the roadmap to malaria elimination/eradication by the year 2050. Viral-vectored vaccines based on adenoviruses and modified vaccinia virus Ankara (MVA) expressing malaria immunogens are currently being used in heterologous prime-boost regimes in clinical trials for induction of strong antigen ...
Sebastian S, Gilbert SC.
europepmc   +3 more sources

Induction of Influenza (H5N8) Antibodies by Modified Vaccinia Virus Ankara H5N1 Vaccine [PDF]

Emerging Infectious Diseases, 2015
To the Editor: Aquatic birds form a natural reservoir of avian influenza viruses from which new human and animal influenza viruses originate. After initial detection in 2010 in China, a new highly pathogenic avian influenza (HPAI) virus of the H5N8 subtype reemerged in ducks in South Korea in 2014 (1,2).
Rory D. de Vries, Heidi L.M. De Gruyter, Theo M. Bestebroer, Mark Pronk, Ron A.M. Fouchier, Albert D.M.E. Osterhaus, Gerd Sutter, Joost H.C.M. Kreijtz, Guus F. Rimmelzwaan   +8 more
doaj   +3 more sources

Modified Vaccinia virus Ankara but not vaccinia virus induces chemokine expression in cells of the monocyte/macrophage lineage [PDF]

Virology Journal, 2015
The orthopoxvirus strain Modified Vaccinia virus Ankara (MVA) rapidly induces innate immune responses. Previously, we demonstrated that CCL2 and CCR1 are important players in MVA induced recruitment of leukocytes to the lung. Alveolar macrophages are sentinel cells in the lung, which are likely amongst the first cells of the immune system to encounter ...
Michael H. Lehmann, Philip J. R. Price, Christine Brandmüller, Gerd Sutter   +3 more
openalex   +5 more sources

Immunogenicity and Safety of Defective Vaccinia Virus Lister: Comparison with Modified Vaccinia Virus Ankara [PDF]

Journal of Virology, 2002
ABSTRACTPotent and safe vaccinia virus vectors inducing cell-mediated immunity are needed for clinical use. Replicating vaccinia viruses generally induce strong cell-mediated immunity; however, they may have severe adverse effects. As a vector for clinical use, we assessed the defective vaccinia virus system, in which deletion of an essential gene ...
B T, Ober, P, Brühl, M, Schmidt, V, Wieser, W, Gritschenberger, S, Coulibaly, H, Savidis-Dacho, M, Gerencer, F G, Falkner   +8 more
openaire   +2 more sources

Modified Vaccinia Virus Ankara Protects Macaques against Respiratory Challenge with Monkeypox Virus [PDF]

Journal of Virology, 2005
ABSTRACT The use of classical smallpox vaccines based on vaccinia virus (VV) is associated with severe complications in both naïve and immune individuals. Modified vaccinia virus Ankara (MVA), a highly attenuated replication-deficient strain of VV, has been proven to be safe in humans and immunocompromised animals, and its efficacy against ...
Stittelaar, KJ, van Amerongen, G, Kondova, I, Kuiken, T, van Lavieren, RF, Pistoor, FHM, Niesters, HGM, van Doornum, G, van der Zeijst, BAM, Mateo, L, Chaplin, PJ, Osterhaus, ADME   +11 more
openaire   +4 more sources