Pre-clinical efficacy and safety of experimental vaccines based on non-replicating vaccinia vectors against yellow fever. [PDF]
PLoS ONE, 2011 BACKGROUND: Currently existing yellow fever (YF) vaccines are based on the live attenuated yellow fever virus 17D strain (YFV-17D). Although, a good safety profile was historically attributed to the 17D vaccine, serious adverse events have been reported,
Birgit Schäfer +8 more
doaj +1 more source
Effects of pre-existing orthopoxvirus-specific immunity on the performance of Modified Vaccinia virus Ankara-based influenza vaccines. [PDF]
Sci Rep, 2018 Altenburg AF +9 more
europepmc +3 more sources
Original encounter with antigen determines antigen-presenting cell imprinting of the quality of the immune response in mice. [PDF]
PLoS ONE, 2009 BACKGROUND:Obtaining a certain multi-functionality of cellular immunity for the control of infectious diseases is a burning question in immunology and in vaccine design.
Valérie Abadie +5 more
doaj +1 more source
Vaccinia Virus: From Crude Smallpox Vaccines to Elaborate Viral Vector Vaccine Design
Biomedicines, 2021 Various vaccinia virus (VACV) strains were applied during the smallpox vaccination campaign to eradicate the variola virus worldwide. After the eradication of smallpox, VACV gained popularity as a viral vector thanks to increasing innovations in genetic ...
Onur Kaynarcalidan +2 more
doaj +1 more source
Viruses, 2021 African swine fever (ASF) has become a global threat to the pig industry and wild suids. Within Europe, including Germany, affected wild boar populations play a major role.
Franziska Tanneberger +4 more
doaj +1 more source
Truncation of gene F5L partially masks rescue of vaccinia virus strain MVA growth on mammalian cells by restricting plaque size [PDF]
, 2015 Modified vaccinia virus Ankara (MVA) is a candidate vaccine vector that is severely attenuated due to mutations acquired during several hundred rounds of serial passage in vitro.
Dobson, Bianca, Tscharke, David C.
core +1 more source
Viruses, 2023 The COVID-19 pandemic caused significant human health and economic consequences. Due to the ability of SARS-CoV-2 to spread rapidly and to cause severe disease and mortality in certain population groups, vaccines are essential for controlling the ...
Georgia Kalodimou +10 more
doaj +1 more source
Population, sexual and reproductive health, rights and sustainable development: forging a common agenda. [PDF]
, 2010 This article suggests that sexual and reproductive health and rights activists seeking to influence the post-2015 international development paradigm must work with sustainable development advocates concerned with a range of issues, including climate ...
Campbell, D. M. +11 more
core +1 more source
Journal of General Virology, 2007 Chorioallantois vaccinia virus Ankara (CVA) is the parental virus of modified vaccinia virus Ankara (MVA), which was derived from CVA by more than 570 passages in chicken embryo fibroblasts (CEF). MVA became severely host-cell-restricted to avian cells and has strongly diminished virulence in mammalian hosts, while maintaining good immunogenicity.
Meisinger-Henschel, Christine +10 more
openaire +5 more sources
Modified vaccinia virus Ankara as a vector for suicide gene therapy [PDF]
Cancer Gene Therapy, 2007 Modified vaccinia virus Ankara (MVA) has been used successfully to express various antigens for the development of vaccines. Here we show that MVA can also be used as an efficient vector for the transfer of suicide genes to cancer cells. We have generated a new and highly potent suicide gene, FCU1, which encodes a fusion protein derived from the yeast ...
P, Erbs +6 more
openaire +2 more sources