Clinical development of Modified Vaccinia virus Ankara vaccines
Vaccine, 2013 The smallpox vaccine Vaccinia was successfully used to eradicate smallpox, but although very effective, it was a very reactogenic vaccine and responsible for the deaths of one or two people per million vaccinated. Modified Vaccinia virus Ankara (MVA) is a replication-deficient and attenuated derivative, also used in the smallpox eradication campaign ...
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Human and bovine respiratory syncytial virus vaccine research and development [PDF]
, 2008 Human (HRSV) and bovine (BRSV) respiratory syncytial viruses (RSV) are two closely related viruses, which are the most important causative agents of respiratory tract infections of young children and calves, respectively.
Deplanche, Martine +2 more
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Safety and immunogenicity of a modified pox vector-based HIV/AIDS vaccine candidate expressing Env, Gag, Pol and Nef proteins of HIV-1 subtype B (MVA-B) in healthy HIV-1-uninfected volunteers: A phase I clinical trial (RISVAC02) [PDF]
, 2011 Clinical Trial, Phase ITo investigate the safety and immunogenicity of a modified vaccinia virus Ankara vector expressing HIV-1 antigens from clade B (MVA-B), a phase-I, doubled-blind placebo-controlled trial was performed.Peer ...
Alcamí, José +25 more
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The development of an AIDS mucosal vaccine [PDF]
, 2010 It is well known that mucosal tissues contain the largest surface area of the human body and are the front line of natural host defense against various pathogens.
Chen, Z, Tang, X
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Synthesis of IFN-β by Virus-Infected Chicken Embryo Cells Demonstrated with Specific Antisera and a New Bioassay [PDF]
, 2004 Transcripts of interferon-α(IFN-α) and IFN-β genes are present in virus-infected chicken cells, but because of a lack of appropriate assays and reagents, it was unclear if biologically active IFN-β is secreted.
Harlin, Olof +4 more
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Attenuation and immunogenicity of host-range extended modified vaccinia virus Ankara recombinants [PDF]
Vaccine, 2013 Modified vaccinia virus Ankara (MVA) is being widely investigated as a safe smallpox vaccine and as an expression vector to produce vaccines against other infectious diseases and cancer. MVA was isolated following more than 500 passages in chick embryo fibroblasts and suffered several major deletions and numerous small mutations resulting in ...
Robin J. Kastenmayer +3 more
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Production of prostaglandin E2 in response to infection with modified vaccinia Ankara virus
Virology, 2012 AbstractProstaglandin E2 (PGE2) is an arachidonic acid (AA)-derived signaling molecule that can influence host immune responses to infection or vaccination. In this study, we investigated PGE2 production in vitro by cells infected with the poxvirus vaccine strain, modified vaccinia Ankara virus (MVA).
Ian T.D. Petty +4 more
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Developing Universal Influenza Vaccines: Hitting the Nail, Not Just on the Head [PDF]
, 2016 Influenza viruses have a huge impact on public health. Current influenza vaccines need to be updated annually and protect poorly against antigenic drift variants or novel emerging subtypes.
Rimmelzwaan, G.F. (Guus) +2 more
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A striking property of recombinant poxviruses: Efficient inducers of in vivo expansion of primed CD8(+) T cells [PDF]
, 2001 CSIC, Ctr Nacl Biotecnol, Madrid 28049, SpainNYU, Sch Med, Dept Med & Mol Parasitol, New York, NY 10010 USAEscola Paulista Med, BR-04023 São Paulo, BrazilEscola Paulista Med, BR-04023 São Paulo, BrazilWeb of ...
Esteban, M. +5 more
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Prevention of infection and disruption of the pathogen transfer chain in elective surgery [PDF]
, 2020 The COVID-19 pandemic has caused us all to stop our normal activities and consider how we can safely return to caring for our patients. There are many common practices (such as an increased use of personal protective equipment) which we are all familiar ...
Chisari, Emanuele +5 more
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