Results 61 to 70 of about 12,579 (242)

Synthesis of IFN-β by Virus-Infected Chicken Embryo Cells Demonstrated with Specific Antisera and a New Bioassay [PDF]

, 2004
Transcripts of interferon-α(IFN-α) and IFN-β genes are present in virus-infected chicken cells, but because of a lack of appropriate assays and reagents, it was unclear if biologically active IFN-β is secreted.
Harlin, Olof, Kaspers, Bernd, Ohnemus, Annette, Schwarz, Heike, Staeheli, Peter   +4 more
core   +1 more source

Tuberculosis vaccine: pipeline approaches and future prospective [PDF]

, 2011
Tuberculosis (TB), despite anti-mycobacterial therapies and vaccine, is a deadly infectious disease with about 12 million incident cases worldwide. Existing Bacillus Calmette-Guérin (BCG) vaccine is unquestionably inexpensive, safe and effective ...
Ankita Singh, L K Dwivedi, Poonam Yadav   +2 more
core   +2 more sources

Removal of the C6 Vaccinia Virus Interferon-β Inhibitor in the Hepatitis C Vaccine Candidate MVA-HCV Elicited in Mice High Immunogenicity in Spite of Reduced Host Gene Expression

Viruses, 2018
Hepatitis C virus (HCV) represents a major global health problem for which a vaccine is not available. Modified vaccinia virus Ankara (MVA)-HCV is a unique HCV vaccine candidate based in the modified vaccinia virus Ankara (MVA) vector expressing the ...
María Q. Marín, Patricia Pérez, Carmen E. Gómez, Carlos Óscar S. Sorzano, Mariano Esteban, Juan García-Arriaza   +5 more
doaj   +1 more source

Quantitative proteomics defines mechanisms of antiviral defence and cell death during modified vaccinia Ankara infection

Nature Communications, 2023
Modified vaccinia Ankara (MVA) virus does not replicate in human cells and is the vaccine deployed to curb the current outbreak of mpox. Here, we conduct a multiplexed proteomic analysis to quantify >9000 cellular and ~80% of viral proteins throughout ...
Jonas D. Albarnaz, Joanne Kite, Marisa Oliveira, Hanqi Li, Ying Di, Maria H. Christensen, Joao A. Paulo, Robin Antrobus, Steven P. Gygi, Florian I. Schmidt, Edward L. Huttlin, Geoffrey L. Smith, Michael P. Weekes   +12 more
doaj   +1 more source

Modified Vaccinia virus Ankara: Innate immune activation and induction of cellular signalling

Vaccine, 2013
Attenuated poxviruses are currently under development as vaccine vectors against a number of diseases including, influenza, HIV, malaria and tuberculosis. Modified Vaccinia virus Ankara (MVA) is an attenuated, replication deficient vaccinia virus (VACV) strain which, similar to replication competent VACV, is highly immunogenic.
Philip J. R. Price, Lino E. Torres-Domínguez, Christine Brandmüller, Gerd Sutter, Michael H. Lehmann   +4 more
openalex   +4 more sources

Safety and immunogenicity of an FP9-vectored candidate tuberculosis vaccine (FP85A), alone and with candidate vaccine MVA85A in BCG-vaccinated healthy adults: a phase I clinical trial. [PDF]

, 2012
The safety and immunogenicity of a new candidate tuberculosis (TB) vaccine, FP85A was evaluated alone and in heterologous prime-boost regimes with another candidate TB vaccine, MVA85A.
Bateman, Cynthia, Gilbert, Sarah C, Hamill, Matthew, Harris, Stephanie A, Hill, Adrian VS, Lawrie, Alison M, Matsumiya, Magali ML, McShane, Helen, Meyer, Joel, Minassian, Angela M, O'Hara, Geraldine A, Pathan, Ansar A, Poulton, Ian D, Poyntz, Hazel C, Rowland, Rosalind, Satti, Iman, Scott, Janet T, Whittaker, Megan, Williams, Nicola   +18 more
core   +2 more sources

Selection of recombinant MVA by rescue of the essential D4R gene

Virology Journal, 2011
Modified vaccinia virus Ankara (MVA) has become a promising vaccine vector due to its immunogenicity and its proven safety in humans. As a general approach for stringent and rapid selection of recombinant MVA, we assessed marker rescue of the essential ...
Ricci Patricia S, Schäfer Birgit, Kreil Thomas R, Falkner Falko G, Holzer Georg W   +4 more
doaj   +1 more source

Non-plaque-forming virions of Modified Vaccinia virus Ankara express viral genes. [PDF]

Virology, 2016
In cell culture infections with vaccinia virus the number of counted virus particles is substantially higher than the number of plaques obtained by titration. We found that standard vaccine preparations of recombinant Modified Vaccinia virus Ankara produce only about 20-30% plaque-forming virions in fully permissive cell cultures.
Lülf AT, Freudenstein A, Marr L, Sutter G, Volz A.   +4 more
europepmc   +3 more sources

Modified vaccinia virus Ankara induces moderate activation of human dendritic cells

Journal of General Virology, 2004
Modified vaccinia virus Ankara (MVA) is a highly attenuated strain known to be an effective vaccine vector. Here it is demonstrated that MVA, unlike standard vaccinia virus (VACV) strains, activates monocyte-derived human dendritic cells (DCs) as testified by an increase in surface co-stimulatory molecules and the secretion of pro-inflammatory ...
Robert, Drillien, Danièle, Spehner, Daniel, Hanau   +2 more
openaire   +2 more sources

Percutaneous Vaccination as an Effective Method of Delivery of MVA and MVA-Vectored Vaccines. [PDF]

PLoS ONE, 2016
The robustness of immune responses to an antigen could be dictated by the route of vaccine inoculation. Traditional smallpox vaccines, essentially vaccinia virus strains, that were used in the eradication of smallpox were administered by percutaneous ...
Clement A Meseda, Vajini Atukorale, Jordan Kuhn, Falko Schmeisser, Jerry P Weir   +4 more
doaj   +1 more source