Assessment of Immunogenicity and Efficacy of a Zika Vaccine Using Modified Vaccinia Ankara Virus as Carriers [PDF]
Pathogens, 2019 Zika virus (ZIKV) is an emerging mosquito-borne flavivirus that has spread to more than 70 countries worldwide since 2015. Despite active research, there are currently no licensed vaccines or therapeutics. We have previously reported the development of various adenoviral vectored vaccine candidates (ChAdOx1 ZIKV) with the ability to stimulate effective
César López-Camacho +6 more
openaire +5 more sources
MNF, an ankyrin repeat protein of myxoma virus, is part of a native cellular SCF complex during viral infection [PDF]
, 2010 Myxoma virus (MYXV), a member of the Poxviridae family, is the agent responsible for myxomatosis, a fatal disease in the European rabbit (Oryctolagus cuniculus).
Bertagnoli, Stéphane +3 more
core +5 more sources
Safety and immunogenicity of an FP9-vectored candidate tuberculosis vaccine (FP85A), alone and with candidate vaccine MVA85A in BCG-vaccinated healthy adults: a phase I clinical trial. [PDF]
, 2012 The safety and immunogenicity of a new candidate tuberculosis (TB) vaccine, FP85A was evaluated alone and in heterologous prime-boost regimes with another candidate TB vaccine, MVA85A.
Bateman, Cynthia +18 more
core +2 more sources
Marker Rescue of the Host Range Restriction Defects of Modified Vaccinia Virus Ankara
Virology, 1998 The severely attenuated and host range (HR) restricted modified vaccinia virus Ankara (MVA) was derived by >500 passages in chick embryo fibroblasts, during which multiple deletions and mutations occurred. To determine the basis of the HR defect, we prepared cosmids from the parental vaccinia virus Ankara genome and transfected them into nonpermissive ...
Jerry R. Sisler +5 more
openaire +3 more sources
Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8+ T cell responses [PDF]
, 2007 Vaccinia virus immunization provides lifelong protection against smallpox, but the mechanisms of this exquisite protection are unknown. We used polychromatic flow cytometry to characterize the functional and phenotypic profile of CD8+ T cells induced by ...
Ambrozak, David R. +13 more
core +3 more sources
Evaluation of modified vaccinia virus Ankara based recombinant SARS vaccine in ferrets
Vaccine, 2005 Severe acute respiratory syndrome (SARS) caused by a newly identified coronavirus (SARS-CoV) remains a threat to cause epidemics as evidenced by recent sporadic cases in China. In this communication, we evaluated the efficacy and safety of two SARS vaccine candidates based on the recombinant modified vaccinia Ankara (MVA) expressing SARS-CoV spike or ...
Hana M. Weingartl +7 more
openaire +2 more sources
Monkeypox Virus: WHO's Second Public Health Emergency of International Concern Within 2 Years
Microbial Biotechnology, Volume 18, Issue 4, April 2025.The figure shows examples of zoonotic diseases and their affected populations. The red arrows indicate the path of monkeypox virus infections first from a wild animal reservoir (rodents, squirrels) as a zoonosis mostly to children in central and west Africa, followed by the 2022/3 epidemic with human‐to‐human transmission in men having sex with men and
Harald Brüssow
wiley +1 more source
Modified Vaccinia Virus Ankara Encoding Influenza Virus Hemagglutinin Induces Heterosubtypic Immunity in Macaques [PDF]
Journal of Virology, 2014 ABSTRACT Current influenza virus vaccines primarily aim to induce neutralizing antibodies (NAbs). Modified vaccinia virus Ankara (MVA) is a safe and well-characterized vector for inducing both antibody and cellular immunity. We evaluated the immunogenicity and protective efficacy of MVA encoding influenza virus hemagglutinin (HA)
Kelsey R. Florek +15 more
openaire +3 more sources
Comparative Evaluation of Extraction Protocols for Point‐Of‐Need Molecular Diagnostics
iLABMED, Volume 3, Issue 1, Page 7-13, March 2025.This study assessed 10 commercially available RNA extraction protocols for their suitability in point‐of‐need molecular diagnostics, focusing on factors such as ease of use, turnaround time, and robustness across different sample types. Protocol VIII emerged as the most flexible and reliable, demonstrating high sensitivity and consistent performance ...
Rea Maja Kobialka +3 more
wiley +1 more source
Dysregulated ribosome quality control in human diseases
The FEBS Journal, Volume 292, Issue 5, Page 936-959, March 2025.Ensuring the synthesis of full‐length, correctly folded proteins is vital for maintaining homeostasis. If a translating ribosome stalls, the trailing ribosomes collide into it, which if left unresolved leads to deleterious effects on the cell due to the accumulation of protein aggregates.
Tom McGirr +2 more
wiley +1 more source