Results 101 to 110 of about 1,820,346 (284)
Disease-modifying treatments for Alzheimer’s disease
Therapeutic Advances in Neurological Disorders, 2011 The first drugs developed for Alzheimer’s disease (AD), acetylcholinesterase inhibitors (AChEI), increase acetylcholine levels, previously demonstrated to be reduced in AD. To date, four AChEI are approved for the treatment of mild-to-moderate AD.
Daniela Galimberti, Elio Scarpini
doaj +1 more source
Multi-instantons in seven dimensions
, 2005 We consider the self-dual Yang-Mills equations in seven dimensions. Modifying the t'Hooft construction of instantons in $d=4$, we find $N$-instanton $7d$ solutions which depend on $8N$ effective parameters and are $E_{6}$-invariant.Comment: 9 pages ...
E. K. Loginov +2 more
core +2 more sources
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
COMPLEX MODIFYING OF LOW-CARBON STEEL
Литьë и металлургия, 2010 The received results testify that introduction into composition complex of modifiier of carbide-forming and surfactant elements promotes increasing of its efficiency on macroand microstructure of steel.
O. S. Komarov +4 more
doaj
, 2016 Using our mathematical framework developed in \cite{cresson-pierret_scale} called \emph{scale dynamics}, we propose in this paper a new way of interpreting the problem of adding or modifying potentials in mechanics and specifically in galactic dynamics ...
Pierret, Frédéric
core
Integrable Anisotropic Evolution Equations on a Sphere
, 2005 V.V. Sokolov's modifying symmetry approach is applied to anisotropic evolution equations of the third order on the n-dimensional sphere. The main result is a complete classification of such equations.
Balakhnev, Maxim Ju. +1 more
core +2 more sources
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source