Results 81 to 90 of about 1,839,177 (303)

The Role of Antibiotic-Target-Modifying and Antibiotic-Modifying Enzymes in Mycobacterium abscessus Drug Resistance

open access: yesFrontiers in Microbiology, 2018
The incidence and prevalence of non-tuberculous mycobacterial (NTM) infections have been increasing worldwide and lately led to an emerging public health problem.
Sakshi Luthra   +3 more
doaj   +1 more source

Relapsing-remitting multiple sclerosis: advances in disease-modifying therapies [PDF]

open access: yes, 2015
Multiple sclerosis is a demyelinating disease affecting the central nervous system. It is the most prevalent disabling neurological condition among young adults, with onset typically between 20 and 40 years of age. Infiltrating immune cells and microglia
Kay, Kathleen Alexandra
core   +1 more source

Modifying Fragility and Collective Motion in Polymer Melts with Nanoparticles

open access: yes, 2011
We investigate the impact of nanoparticles (NP) on the fragility and cooperative string-like motion in a model glass-forming polymer melt by molecular dynamics simulation.
Douglas, Jack F., Starr, Francis W.
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Improved design of electrophoretic equipment for rapid sickle-cell-anemia screening [PDF]

open access: yes, 1974
Effective mass screening may be accomplished by modifying existing electrophoretic equipment in conjunction with multisample applicator used with cellulose-acetate-matrix test paper.
Hirsch, I., Reddick, J. M.
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

NANOSTRUCTURAL PROCESSES OF MELTING AND MOULDING OF THE EUTECTIC SILUMIN

open access: yesЛитьë и металлургия, 2016
It is shown that melting and molding of the eutectic silumin are difficult physical and chemical nanostructural processes. In them the major role is played by the centers of crystallization of the eutectic dendrites of aluminum, aluminum nanocrystals ...
V. Yu. Stetsenko
doaj  

Revisiting the modifying environment approach

open access: yesScottish Journal of Residential Child Care, 2010
Theory is a fundamental piece of professional child and youth care practice, and finding useful, life-space applicable theory that addresses the complex issues presented by the young people in child and youth care is a continual challenge.
Jack Phelan
doaj   +1 more source

Modifying the Sum Over Topological Sectors and Constraints on Supergravity

open access: yes, 2010
The standard lore about the sum over topological sectors in quantum field theory is that locality and cluster decomposition uniquely determine the sum over such sectors, thus leading to the usual theta-vacua.
A Caldararu   +28 more
core   +1 more source

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