Results 71 to 80 of about 894,676 (256)
Novel eukaryotic enzymes modifying cell-surface biopolymers
Biology Direct, 2010 Background Eukaryotic extracellular matrices such as proteoglycans, sclerotinized structures, mucus, external tests, capsules, cell walls and waxes contain highly modified proteins, glycans and other composite biopolymers.
Aravind L, Anantharaman Vivek
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
The Role of Disease Modifying Therapy In The Treatment of Relapsing Remitting Multiple sclerosis
, 2018 Although there is no definitive cure for multiple sclerosis, immunomodulatory agents developing since the mid 1990’s have surfaced and produced beneficial effects in decreasing relapse rate and, some agents more than others, reducing disability ...
Rawashdeh, Amir
core
Lipid profiles in rheumatoid arthritis patients treated with disease-modifying antirheumatic drugs
, 2014 Cardiovascular events are the main cause of the increased risk of death in patients with rheumatoid arthritis (RA). Death rates associated with cardiovascular diseases in RA are 50% higher in comparison with the general population.
Piotr Głuszko +2 more
core +1 more source
CRISPR: modifying the life science landscape
BioTechniques, 2016 From lampreys to human stem cells, the CRISPR/Cas9 system is challenging our notions of what is possible with genome editing. Nathan Blow talks to researchers pushing the boundaries of CRISPR/Cas9 technology to expand our understanding of biology.
Nathan Blow
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
beta-1,3-glucan modifying enzymes in Aspergillus fumigatus
Frontiers in Microbiology, 2013 In Aspergillus fumigatus like in other filamentous ascomycetes, beta-1,3-glucan constitutes a prominent cell wall component being responsible for rigidity of the cell wall structure. In filamentous fungi, softening of the cell wall is absolutely required
Isabelle eMouyna +2 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
The application of modifying factors [PDF]
, 2016 : Demonstration of the feasibility of economic extraction is not required before Exploration Results or Mineral Resources are reported. However, the use of Modifying Factors is fundamental in demonstrating feasibility and thus in converting a Mineral ...
Rupprecht, S.M.
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Experiences of Relapsing Remitting Multiple Sclerosis and Disease Modifying Treatment: A phenomenological inquiry [PDF]
A review of the body of knowledge has provided an insightful overview of the significant strides taken in the field of multiple sclerosis. For instance, the literature has made clear the considerable impact this autoimmune disease can have on an ...
Patel, Dipesh
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