Results 61 to 70 of about 894,676 (256)

INFLUENCE OF PARAMETERS OF CRYSTALLIZATION ON MODIFYING OF AN ALLOY

open access: yesЛитьë и металлургия, 2015
It is shown that extent of modifying of an alloy is proportional to overcooling at its hardening, viscosity of fusion and interphase superficial energy of crystals of the leading phase.
V. Yu. Stetsenko
doaj  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Disease-modifying therapies in relapsing–remitting multiple sclerosis

open access: yes, 2010
Fabricio González-Andrade1, José Luis Alcaraz-Alvarez21Department of Medicine, Metropolitan Hospital, Quito, Ecuador; 2School of Medicine, University of Mayab, Merida, MexicoClinical question: What is the best current disease ...
Fabricio González-Andrade   +1 more
core  

NANOSTRUCTURAL PROCESSES AT MELTING AND MOULDING OF SILUMINS

open access: yesВесці Нацыянальнай акадэміі навук Беларусі: Серыя фізіка-тэхнічных навук, 2017
The existing theories of liquid state, crystallization and modifying don’t allow determining nanostructural physical and chemical mechanisms of melting and casting of silumins.
E. I. Marukovich, V. Y. Stetsenko
doaj  

Evolving targets for lipid‐modifying therapy

open access: yesEMBO Molecular Medicine, 2014
The pathogenesis and progression of atherosclerosis are integrally connected to the concentration and function of lipoproteins in various classes. This review examines existing and emerging approaches to modify low‐density lipoprotein and lipoprotein (a),
Rose Q Do   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Disease-modifying therapies (DMTs) costs.

open access: yes, 2022
Disease-modifying therapies (DMTs) costs.
Mihaela Nica (3357893)   +5 more
core   +1 more source

The Role of Antibiotic-Target-Modifying and Antibiotic-Modifying Enzymes in Mycobacterium abscessus Drug Resistance

open access: yesFrontiers in Microbiology, 2018
The incidence and prevalence of non-tuberculous mycobacterial (NTM) infections have been increasing worldwide and lately led to an emerging public health problem.
Sakshi Luthra   +3 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

Disease-modifying drugs in Alzheimer's disease

open access: yes, 2013
Laura Ghezzi, Elio Scarpini, Daniela Galimberti Neurology Unit, Department of Pathophysiology and Transplantation, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy Abstract: Alzheimer's disease (AD)
Galimberti D, Scarpini E, Ghezzi L
core  

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