Results 111 to 120 of about 1,839,177 (303)
Medicare Part D: Simplifying the Program and Improving the Value of Information for Beneficiaries [PDF]
, 2008 Examines options for simplifying Medicare's prescription drug benefit, including streamlining benefit procedures and descriptions; further standardizing benefit parameters, especially cost-sharing rules; and modifying rules on plan ...
Jack Hoadley
core
Multi-instantons in seven dimensions
, 2005 We consider the self-dual Yang-Mills equations in seven dimensions. Modifying the t'Hooft construction of instantons in $d=4$, we find $N$-instanton $7d$ solutions which depend on $8N$ effective parameters and are $E_{6}$-invariant.Comment: 9 pages ...
E. K. Loginov +2 more
core +2 more sources
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
ON MODIFYING OF HYPEREUTECTIC SILUMINS
Литьë и металлургия, 2008 It is shown that efficiency of hypereutectic silumin is determined in general by deoxidizing ability of modifiers.
V. Ju. Stetsenko
doaj
Dynamic Virtual Join Point Dispatch [PDF]
, 2006 Conceptually, join points are points in the execution of a program and advice is late-bound to them. We propose the notion of virtual join points that makes this concept explicit not only at a conceptual, but also at implementation level.
Bockisch, Christoph +2 more
core +3 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
INCREASE OF THE MODIFYING EFFICIENCY
Литьë и металлургия, 2006 Short review and analysis of the basic nine well known ways of the metals and alloys modifying are given. It is shown that casting by means of mixing of one- and two-phase melts, casting by quenching hardening, casting in crystallyzer with jet cooling is
E. I. Marukovich, V. Ju. Stetsenko
doaj
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Epigenome Modifying Tools In Asthma [PDF]
, 2015 Adcock,, Brook, PO, Durham, AL, Perry, M
core +1 more source