Results 121 to 130 of about 894,676 (256)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

A parametrised version of Moser's modifying terms theorem [PDF]

A sharpened version of Moser's `modifying terms' KAM theorem is derived, and it is shown how this theorem can be used to investigate the persistence of invariant tori in general situations, including those where some of the Floquet exponents of the ...
Wagener, F.O.O.
core  

Real‐world persistence of multiple sclerosis disease‐modifying therapies

Background and purpose: Treatment persistence is the continuation of therapy over time. It reflects a combination of treatment efficacy and tolerability.
Hu, Mo, Russell, Melanie J., Norris, Sam, Shawe‐Taylor, Marianne J., Harding, Katharine E., Evangelou, Nikos, Buckley, Lauren, Galea, Ian, Mescall, Naomi, Ramsay, Stephen J., St John, Frederika A., McDonnell, Gavin V., Hibbert, Aimee M., Arun, Tarunya, Dobson, Ruth, Kalra, Seema, Anderson, Valerie M., George, Sumi, Lim, Chia‐Hui E., Mathews, Joela T. M., Ford, Helen L., Robertson, Neil P., Rice, Claire M., Tallantyre, Emma C., Ingram, Gillian, Froud, Joseph L. J., Hughes, Stella E., Williams, Thomas E., Gray, Orla M.   +28 more
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Genetic Insights Into Lipid Traits and Lipid-Modifying Drug Targets in Pregnancy Complications: A Two-Sample Mendelian Randomization Study [PDF]

Huijing Shao,1,* Chang Xu,2,* Caihong Zhang,2 Lirong Li,3 Pengfei Wu,4 Zixi Chen,5 Rui Guan2 1Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, People’s
Shao H, Chen Z, Wu P, Xu C, Guan R, Zhang C, Li L   +6 more
core  

Report on Noun-Modifying Clauses in Discourse [PDF]

, 1997
Relative clause construction has been generally studied in terms of the syntactic structure, and few researches on the function of noun-modifying clauses have been made. This paper deals with the usage of noun-modifying clauses in discouse. To summarize,
大塚, 容子, オオツカ, ヨウコ, Otsuka, Yoko   +2 more
core  

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Modifying an ill-fitting simple face mask

Pediatrics and Neonatology, 2023
Abhishek Bharadwaj, Sandeep Gade
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

LTL Model Checking of Self Modifying Code.

, 2019
International audienceSelf modifying code is code that can modify its own instructions during the execution of the program. It is extensively used by malware writers to obfuscate their malicious code. Thus, analysing self modifying code is nowadays a big
Ye, Xin, Touili, Tayssir
core