Results 51 to 60 of about 61,255 (309)

Digitally enabled modular construction for promoting modular components reuse: A UK view [PDF]

, 2021
The UK construction sector is facing multiple challenges associated with low productivity, unreliable project delivery, poor performance, skilled labour shortages, and resource inefficiency.
Poologanathan, K, Eleni Iacovidou, Konstantinos Daniel Tsavdaridis, Iacovidou, E., Iacovidou, E, Keerthan Poologanathan, Purnell, P, Poologanathan, K., Tsavdaridis, KD, Phil Purnell, Purnell, P., Tsavdaridis, K, Tsavdaridis, K. D.   +12 more
core   +1 more source

A preliminary preclinical assessment of macromolecular crowding in tissue engineering

Science Progress
Objectives Although bone marrow mesenchymal stromal cells (BMSCs) are extensively used in biomedicine, they have yet to be used in the commercial development of a tissue engineered medicine. It has been argued that the major roadblock in their commercial
Kyriakos Spanoudes, Laura Trujillo Cubillo, Stefanie H. Korntner, Diana Gaspar, Dimitrios I. Zeugolis   +4 more
doaj   +1 more source

Integrated BIM and VR for Interactive Aerodynamic Design and Wind Comfort Analysis of Modular Buildings

Buildings, 2022
Modular building is becoming a common sight due to government policies promoting greater automation and productivity. When moving towards modularity, indoor comfort within volumetric modules, such as levels of humidity and temperature, natural ...
Vincent J. L. Gan, Ting Liu, Kexin Li
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Optimised Cold-Formed Steel Beams in Modular Building Applications [PDF]

, 2020
Modular Building Systems (MBS) has seen an accelerating growth in the construction sector owing to its potential advantages, such as quick erection, improved energy efficiency and less reliant on good weather over conventional construction methods ...
Poologanathan, K, Gatheeshgar, P, Nagaratnam, B, Tsavdaridis, Konstantinos Daniel, Iacovidou, Eleni, Gunalan, S., Poologanathan, Keerthan, Iacovidou, E., Iacovidou, E, Gatheeshgar, Perampalam, Nagaratnam, B., Gunalan, Shanmuganathan, Gunalan, S, Nagaratnam, Brabha, Poologanathan, K., Tsavdaridis, KD, Gatheeshgar, P., Perampalam, G, Tsavdaridis, K. D.   +18 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Novel discrete diaphragm system of concrete high-rise modular buildings

, 2022
Modular high-rises are attractive for metropolises, but few applications exist, partly due to the lack of knowledge about their lateral behaviors. Existing concrete modular high-rises usually adopt a time-consuming and labor-intensive cast-in-situ ...
Pan, Wei, Zhang, Yang, Zhen Wang, Yang Zhang, WANG, Z, Wei Pan, Wang, Zhen, ZHANG, Y, Pan, W   +8 more
core   +2 more sources

Modular houses as a form of sustainable construction

Budownictwo o Zoptymalizowanym Potencjale Energetycznym, 2023
The article discusses the currently developing technology for building economical and energy-saving modular houses. Based on the literature analysis of historical and new modular construction solutions, an attempt was made to classify modular houses and ...
Andrzej Kysiak, Bogusław Szuba
doaj   +1 more source

The Development of Modular Building in China

DEStech Transactions on Engineering and Technology Research, 2017
Modular building is a new-type building structure, which has obvious benefits such as energy-saving, rapid construction, efficient manufacturing, and good quality, comparing with the traditional building. The technique can save Chinese construction industry from the dilemma of high pollution, high energy consumption and poor efficiency, and be of great
Yan-juan HAN, Wen-zheng ZHU
openaire   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source