Results 61 to 70 of about 61,255 (309)
Modular Games for Coalgebraic Fixed Point Logics
, 2008 We build on existing work on finitary modular coalgebraic logics [3,4], which we extend with general fixed points, including CTL- and PDL-like fixed points, and modular evaluation games.
Sadrzadeh, Mehrnoosh, Cirstea, Corina
core +2 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
The effectiveness of the modular technology lab in the Mosinee Middle School [PDF]
, 2002 Plan BTechnology Education has taken on many faces over the last twenty years. Making a transition from the Manual Arts to Industrial Arts took nearly fifty years.
Masterson, David W.
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Evaluating Modular House Construction Projects: A Delphi Method Enhanced by Conversational AI
BuildingsThis study focuses on evaluating modular house construction projects, which is a critical segment within sustainable building practices. Despite the significant advantages of modular construction, such as enhanced resource efficiency and reduced ...
Augustinas Maceika +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Selection of Renewable Energy Sources for Modular and Mobile “Green Classroom” Facilities
EnergiesThis article aims to demonstrate the technical capabilities and effectiveness of an energy production and management system for school facilities using a modular solution. The system is assumed to generate electricity from renewable sources, such as wind
Tomasz Węgiel +8 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Enhancing the lateral performance of modular buildings through innovative inter-modular connections
, 2021 Steel modular constructions involve the manufacture of fully equipped three-dimensional prefabricated modules in factory-controlled settings which are then transported to construction sites and assembled to form a complete structure. Adjacent modules are
Aghdamy, S +4 more
core +1 more source