Results 61 to 70 of about 99,696 (310)
On Modularity, Indistinguishability and Generalized Metrics: Duality and Aggregation
MathematicsIn this paper, we prove that, on the one hand, a duality relationship between different types of modular T-transitive relations and the reciprocal modular generalized metrics exists and, on the other hand, that, based on this duality, a construction of ...
Gabriel Jaume-Martin +3 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Singular moduli of rth Roots of modular functions
Open Mathematics, 2023 When singular moduli of Hauptmodules generate ring class fields (resp. ray class fields) of imaginary quadratic fields, using the theory of Shimura reciprocity law, we determine a necessary and sufficient condition for singular moduli of rrth roots of ...
Choi SoYoung
doaj +1 more source
Wach modules and Iwasawa theory for modular forms [PDF]
We define a family of Coleman maps for positive crystalline p-adic representations of the absolute Galois group of Qp using the theory of Wach modules.
Lei, Antonio +2 more
core +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Modular equations and distortion functions [PDF]
The Ramanujan Journal, 2007 Modular equations occur in number theory, but it is less known that such equations also occur in the study of deformation properties of quasiconformal mappings. The authors study two important plane quasiconformal distortion functions, obtaining monotonicity and convexity properties, and finding sharp bounds for them.
Anderson, G. D. +2 more
openaire +3 more sources
Integrated Management Software for Factory Production of Modular Buildings
Advances in Civil Engineering, 2019 After the first modular construction project in Korea in 2003, the scope and demand for modular systems have gradually increased. However, modular producers in Korea utilize spreadsheets to manage the process, manpower, and materials required for modular
SungHoon Nam +3 more
doaj +1 more source
Functional Annotation of Hierarchical Modularity
PLoS ONE, 2012 In biological networks of molecular interactions in a cell, network motifs that are biologically relevant are also functionally coherent, or form functional modules. These functionally coherent modules combine in a hierarchical manner into larger, less cohesive subsystems, thus revealing one of the essential design principles of system-level cellular ...
Kanchana Padmanabhan +2 more
openaire +4 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source