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Synthetic biology of modular proteins [PDF]
Bioengineered, 2016 The evolution of natural modular proteins and domain swapping by protein engineers have shown the disruptive potential of non-homologous recombination to create proteins with novel functions or traits. Bacteriophage endolysins, cellulosomes and polyketide synthases are 3 examples of natural modular proteins with each module having a dedicated function.
Veerle E T, Maervoet, Yves, Briers
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From molecular to modular cell biology [PDF]
Nature, 1999 Cellular functions, such as signal transmission, are carried out by 'modules' made up of many species of interacting molecules. Understanding how modules work has depended on combining phenomenological analysis with molecular studies. General principles that govern the structure and behaviour of modules may be discovered with help from synthetic ...
L H, Hartwell +3 more
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OpenCOR: a modular and interoperable approach to computational biology [PDF]
Frontiers in Physiology, 2015 Computational biologists have been developing standards and formats for nearly two decades, with the aim of easing the description and exchange of experimental data, mathematical models, simulation experiments, etc. One of those efforts is CellML (cellml.org), an XML-based markup language for the encoding of mathematical models.
Alan Garny, Peter Hunter
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Bioinformatics, 2009 Abstract Summary: The modeling tool ProMoT facilitates the efficient and comprehensible setup and editing of modular models coupled with customizable visual representations. Since its last major publication in 2003, ProMoT has gained new functionality in particular support of logical models, efficient editing, visual exploration, model ...
Mirschel, S. +4 more
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What symbionts teach us about modularity
Frontiers in Bioengineering and Biotechnology, 2013 The main goal of Synthetic Biology is to apply engineering principles to biotechnology in order to make life easier to engineer. These engineering principles include modularity: decoupling of complex systems into smaller, orthogonal subsystems that can ...
Manuel ePorcar +4 more
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A Method Based on Total Variation for Network Modularity Optimization using the MBO Scheme [PDF]
, 2013 The study of network structure is pervasive in sociology, biology, computer science, and many other disciplines. One of the most important areas of network science is the algorithmic detection of cohesive groups of nodes called "communities". One popular
Andrea +4 more
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Formalizing Modularization and Data Hiding in Synthetic Biology [PDF]
ACM Journal on Emerging Technologies in Computing Systems, 2014 Biological systems employ compartmentalization and other co-localization strategies in order to orchestrate a multitude of biochemical processes by simultaneously enabling “data hiding” and modularization. This article presents recent research that embraces compartmentalization and co-location as an organizational programmatic principle in
Fellermann H +3 more
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Guidelines for Rational Cancer Therapeutics
Frontiers in Oncology, 2017 Traditionally, cancer therapy has relied on surgery, radiation therapy, and chemotherapy. In recent years, these interventions have become increasingly replaced or complemented by more targeted approaches that are informed by a deeper understanding of ...
Byunghee Yoo +2 more
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SiFSO: Fish Swarm Optimization-Based Technique for Efficient Community Detection in Complex Networks
Complexity, 2020 Efficient community detection in a complex network is considered an interesting issue due to its vast applications in many prevailing areas such as biology, chemistry, linguistics, social sciences, and others.
Yasir Ahmad +7 more
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Shoot-root signal circuit: Phytoremediation of heavy metal contaminated soil
Frontiers in Plant Science, 2023 High concentrations of heavy metals in the environment will cause serious harm to ecosystems and human health. It is urgent to develop effective methods to control soil heavy metal pollution.
Shiyan Bai, Xiao Han, Dan Feng
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