Results 71 to 80 of about 1,844,961 (296)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Module Checking

Information and Computation, 2001
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Orna Kupferman, Moshe Y. Vardi, Pierre Wolper   +2 more
openaire   +3 more sources

A FtsZ cis disassembly element acts in Z-ring assembly during bacterial cell division

Nature Communications
Bacterial cell division hinges on the Z-ring, an architecture built from the dynamical assembly and disassembly of FtsZ proteins. This delicate balance ensures not only apparent stability, but also continuous remodeling, both of which are required for Z ...
Huijia Yin, Yang Liu, Ying Zhao, Pengyue Chen, Zengyi Chang   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

On coefficient modules of arbitrary modules

Proceedings of the Edinburgh Mathematical Society
Abstract Let $(R, \mathfrak{m})$ be a d -dimensional Noetherian local ring that is formally equidimensional, and let
Pedro Lima, Marcela Ferrari, Victor Jorge Pérez   +2 more
openaire   +2 more sources

Tough asymmetric thermochromic ionogels via dynamic in situ phase separation for dual-modal smart optical switching

Nature Communications
Despite significant advances in thermochromic materials (TCMs) for smart optical switching, achieving simultaneous optimization of optical switching, mechanical robustness, and environmental tolerance remains a critical challenge for their real-world ...
Guoli Du, Jianing Li, Changxing Wang, Jianing Li, Yayun Ning, Yifan Yue, Yuechi Xie, Sen Yang, Xuegang Lu   +8 more
doaj   +1 more source

Stabilities, Electronic Structures, and Bonding Properties of Iron Complexes (E1E2)Fe(CO)2(CNArTripp2)2 (E1E2=BF, CO, N2, CN−, or NO+)**

ChemistryOpen, 2020
The coordination of 10‐electron diatomic ligands (BF, CO N2) to iron complexes Fe(CO)2(CNArTripp2)2 [ArTripp2=2,6‐(2,4,6‐(iso‐propyl)3C6H2)2C6H3] have been realized in experiments very recently (Science, 2019, 363, 1203–1205).
Gerui Pei, Dr. Pei Zhao, Song Xu, Xintian Zhao, Prof. Chuncai Kong, Prof. Zhimao Yang, Prof. Masahiro Ehara, Prof. Tao Yang   +7 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

A Review of Artificial Intelligence‐Driven Innovations in Soft Magnetic Materials Optimization: Current Trends and Future Horizons

MetalMat
With the continuous accumulation of data, machine learning is playing an increasingly important role in materials science, especially demonstrating significant advantages in predicting material compositions and developing new alloy systems for soft ...
Yichuan Tang, Shaopeng Liu, Silong Li, Ruonan Ma, Yue Li, Kun Wang, Minxia Fang, Chao Zhou, Sen Yang, Yin Zhang   +9 more
doaj   +1 more source

Modulator-free quadrature amplitude modulation signal synthesis

, 2014
The ability to generate high-speed on-off-keyed telecommunication signals by directly modulating a semiconductor laser’s drive current was one of the most exciting prospective applications of the nascent field of laser technology throughout the 1960s ...
Kelly, Brian, O’Carroll, John, Slavík, Radan, Phelan, Richard, Richardson, David J., Liu, Zhixin, Kakande, Joseph   +6 more
core   +1 more source