Results 101 to 110 of about 766,195 (336)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Drivers and modulators in the central auditory pathways

Frontiers in Neuroscience, 2010
The classic view of auditory information flow depicts a simple serial route from the periphery through tonotopically-organized nuclei in the brainstem, midbrain and thalamus, ascending eventually to the neocortex.
Charles C Lee, S. M Sherman
doaj   +1 more source

Sirtuin Modulators [PDF]

, 2011
Members of the sirtuin family including the founding protein Sir2 in Saccharomyces cerevisiae have been linked to lifespan extension in simple organisms. This finding prompted evaluation of the role of Sir2 orthologues in many aging-associated conditions including neurodegeneration, type II diabetes and cancer.
Sumit S, Mahajan, Vid, Leko, Julian A, Simon, Antonio, Bedalov   +3 more
openaire   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Modulating antibody N-glycosylation through feed additives using a multi-tiered approach

Frontiers in Bioengineering and Biotechnology
Glycosylation of recombinant proteins is a post-translational modification that affects multiple physicochemical and biological properties of proteins.
Jaka Kranjc, Lovro Kramer, Miha Mikelj, Marko Anderluh, Anja Pišlar, Matjaž Brinc   +5 more
doaj   +1 more source

Glicoproteína-P, resistência a múltiplas drogas (MDR) e relação estrutura-atividade de moduladores P-glycoprotein and multidrug resistance: structure-activity relationships of modulators

Química Nova, 2010
Multidrug resistance, MDR is a major obstacle for cancer chemotherapy. MDR can be reversed by drugs that vary in their chemical structure and main biological activity.
Paula C. Huber, Cintia H. Maruiama, Wanda P. Almeida   +2 more
doaj   +1 more source

Space Evaluation of Optical Modulators for Microwave Photonic On-Board Applications [PDF]

, 2010
Since several years, perspectives and assets offered by photonic technologies compared with their traditional RF counterparts (mass and volume reduction, transparency to RF frequency, RF isolation), make them particularly attractive for space ...
Barbero, Juan, Benazet, M., Esquivias Moscardo, Ignacio, Karafolas, Nikos, Le Kernec, Arnaud, López Hernández, Francisco, Maignan, M., Peñate, L., Sotom, M.   +8 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source