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Diagnostic features of initial demyelinating events associated with serum MOG-IgG

Journal of Neuroimmunology, 2020
Myelin oligodendrocyte glycoprotein (MOG)-IgG associated disorders are increasingly recognized as a distinct disease entity. However, diagnostic sensitivity and specificity of serum MOG-IgG as well as recommendations for testing are still debated.Between October 2015 and July 2017 we tested serum MOG-IgG in 91 adult patients (49 females) with a ...
Orlandi, Riccardo, Mariotto, Sara, Ferrari, Sergio, Gobbin, Francesca, Sechi, Elia, Capra, Ruggero, Mancinelli, Chiara Rosa, Bombardi, Roberto, Zuliani, Luigi, Zoccarato, Marco, Rossi, Francesca, Camera, Valentina, Ferraro, Diana, Benedetti, Maria Donata, Reindl, Markus, Gajofatto, Alberto   +15 more
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MOG-IgG is rare in AQP4-IgG seronegative NMO phenotype in Brazil

Multiple Sclerosis and Related Disorders
Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune disease most frequently characterized by a neuromyelitis optica (NMO) phenotype, comprising both simultaneous or sequential optic neuritis (ON) and longitudinally extensive transverse myelitis (LETM). Symptoms of brainstem, diencephalic and cerebral involvement may also occur.
Marco Lana-Peixoto, Denison Pedrosa, Thales Ponsa   +2 more
exaly   +3 more sources

Refining cell-based assay to detect MOG-IgG in patients with central nervous system inflammatory diseases [PDF]

Multiple Sclerosis and Related Disorders, 2020
Background Given that the spectrum of myelin oligodendrocyte glycoprotein immunoglobulin G (MOG-IgG) associated disease is yet to be fully defined, development of sensitive and highly specific assays to identify MOG-IgG is crucial to precisely define the
So Yeon Kim, Woojun Kim, Yesel Kim
exaly   +2 more sources

Peripheral neuropathy and MOG-IgG: A clinical and neuropathological retrospective study

Multiple Sclerosis and Related Disorders, 2022
Myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) may rarely be associated with peripheral nervous system involvement. We aimed to test MOG-Abs in patients with undetermined peripheral neuropathy (PN).Consecutive patients with available sural nerve biopsy and paired serum sample were retrospectively identified (January, 1st 2016-November, 1st ...
Alessandro Dinoto, Noemi Maria Licciardi, Markus Reindl, Vanessa Chiodega, Kathrin Schanda, Sara Carta, Romana Höftberger, Sergio Ferrari, Sara Mariotto   +8 more
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“FLAMES: A novel burning entity in MOG IgG associated disease”

Multiple Sclerosis and Related Disorders, 2021
FLAMES is a new clinico-radiological sub entity of myelin oligodendrocyte glycoprotein (MOG) antibody associated disease (MOGAD). FLAMES is characterized by fluid attenuated inversion recovery (FLAIR) imaging showing hyperintense cortical lesions, in MOG associated Encephalitis with Seizures.
Kshiteeja, Jain, Ajith, Cherian, Divya, K P, Rajalakshmi, P, Bejoy, Thomas, Nandana, J   +5 more
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Deciphering anti-MOG IgG antibodies: Clinical and radiological spectrum, and comparison of antibody detection assays

Journal of the Neurological Sciences, 2020
IgG antibodies to myelin oligodendrocyte glycoprotein (MOG) detected by cell based assays (CBA) have been identified in a constantly expanding spectrum of CNS demyelinating disorders. However, a universally accepted CBA has not been adopted yet. We aimed
Dimitrios Tzanetakos, Maria Anagnostouli, Marianthi Breza   +2 more
exaly   +3 more sources

Persistent MOG-IgG positivity is a predictor of recurrence in MOG-IgG-associated optic neuritis, encephalitis and myelitis

Multiple Sclerosis Journal, 2018
Background: MOG-IgG-associated optic neuritis, encephalitis and myelitis (MONEM) is a recently recognized group of inflammatory central nervous system (CNS) disorders distinct from multiple sclerosis and neuromyelitis optica spectrum disorders.
Luana Michelli Oliveira, Samira Luisa Apóstolos-Pereira, Milena Sales Pitombeira, Pedro Henrique Bruel Torretta, Dagoberto Callegaro, Douglas Kazutoshi Sato   +5 more
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MOG-IgG Associated Disease (MOG-AD) in Adults

Current Treatment Options in Neurology, 2021
This review offers a look into available treatment strategies for patients with MOG-IgG associated disease (MOG-AD). We will focus on evidence-based management options in the acute setting. We will also present recommendations for initiation of long-term immunotherapy for patients with a relapsing course and discuss our approach for monitoring disease ...
Petra Brayo, Suma Shah
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MOG-IgG serological status matters in paediatric ADEM

Journal of Neurology, Neurosurgery & Psychiatry, 2014
Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disease of the central nervous system (CNS) characterised by encephalopathy and other neurological manifestations. ADEM is a heterogeneous syndrome predominantly found in the paediatric population.
Tatsuro, Misu, Douglas Kazutoshi, Sato, Ichiro, Nakashima, Kazuo, Fujihara   +3 more
openaire   +2 more sources

Clinical Characteristics and Treatment of MOG-IgG–Associated Optic Neuritis

Current Neurology and Neuroscience Reports, 2019
Antibodies against myelin oligodendrocyte glycoprotein (MOG) are associated with a unique acquired central nervous system demyelinating disease-termed MOG-IgG-associated disorder (MOGAD)-which has a variety of clinical manifestations, including optic neuritis, transverse myelitis, acute disseminating encephalomyelitis, and brainstem encephalitis.
Deena A, Tajfirouz, M Tariq, Bhatti, John J, Chen   +2 more
openaire   +2 more sources