Results 71 to 80 of about 3,487 (207)

Real-Life Evaluation of the MOGAD Diagnostic Criteria [PDF]

Background and objectives: Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) international panel criteria have been recently proposed to guide MOGAD diagnosis. The aim of this study was to evaluate the criteria performance and
Rossi F, Gajofatto A, Massacesi L, Mariotto S, Volonghi I, Virgilio E, Dinoto A, Cantalupo G, Marziali A, Nosadini M, Rossi P, Carta S, Bozzetti S, Cortese R, Calabria F, Gastaldi M, De Luca G, Giannoccaro MP, Del Zotto E, De Biase S, Capobianco M, Cornacchini S, Cossu A, Grazian L, Zuliani L, Orlandi R, Sartori S, Brambilla L, Maniscalco GT, Ferraro D, Bianchi MR, Greco G, Tortorella C, Trentinaglia M, Caleri F, Masciocchi S, Risi M, Vogrig A, Sechi E, Mancinelli C, Damato V, Zoccarato M, Perelli A   +42 more
core   +2 more sources

Structural, quantitative, and functional brain MRI findings in MOGAD: a comparison with NMOSD-AQP4 and MS [PDF]

, 2022
In the past fifteen years two new antibody-mediated Central Nervous System (CNS) diseases, have been identified as distinct from multiple sclerosis (MS): Aquaporin-4-antibody (AQP4-Ab) and the more recently discovered myelin oligodendrocyte glycoprotein ...
Messina, Silvia
core   +1 more source

MOGAD: abordagem diagnóstica e terapêutica [PDF]

, 2023
A mielina oligodendrócito glicoproteína anticorpo associada à doença, ou MOGAD, é uma patologia inflamatória autoimune do sistema nervoso central, mediada por um processo desmielinizante.
Pacheco, Andrea Veronica Garcia, Iñiguez, Juan Antonio Coyago, Pizarro, Cyndi Karen Jaramillo   +2 more
core   +1 more source

Early Clinical and Cerebrospinal Fluid Predictors of 1‐Year Recurrence in Autoimmune GFAP Astrocytopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP‐A) is an inflammatory central nervous system disorder with variable outcomes. Relapse occurs in a subset of patients, but early predictors remain unclear. We aimed to identify admission‐available features associated with 1‐year recurrence and develop an interpretable ...
Qingting Hong, Yuping Xiao, Yuhan Wu, Ziyuan Huang, Weishan Liang, Li Xiao, Yaqing Shu, Tingting Lu, Yanyu Chang, Wei Qiu, Yuge Wang   +10 more
wiley   +1 more source

Table_7_Volumetric Brain Loss Correlates With a Relapsing MOGAD Disease Course.DOCX

, 2022
BackgroundMyelin oligodendrocyte glycoprotein antibody disorders (MOGAD) have evolved as a distinct group of inflammatory, demyelinating diseases of the CNS.
Omri Zveik (12283328), Ariel Rechtman (12283325), Benjamin Uliel (12283331), Atira S. Bick (12283337), Livnat Brill (3425690), Adi Vaknin-Dembinsky (110061), Netta Levin (711894), Nitzan Haham (12283334)   +7 more
core   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Study of Clinical, Radiological and Laboratory Features in Neuromyelitis Optica Spectrum Disorder and Myelin Oligodendrocytes Glycoprotein Associated Disorder at a Tertiary Care Hospital in India

Medical Journal of Dr. D.Y. Patil Vidyapeeth
Introduction: Neuromyelitis optica spectrum disorders (NMOSD) and Myelin oligodendrocytes glycoprotein antibody-associated disease (MOGAD) are two important central nervous system demyelinating disorders.
Shalesh Rohatgi, Furqan Khan, Prajwal Rao, Satish Nirhale, Pravin Naphade, Pranit D. Khandait   +5 more
doaj   +1 more source

Severe ADEM‐Like Neuroinflammatory Disease and Cerebrovascular Fragility With Recurrent Pseudoaneurysms and Moyamoya in a Familial Germline CBL Mutation: Expanding the Clinical Phenotype

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Heterozygous germline variants in CBL disrupt its function as a negative regulator of the Ras/MAPK pathway, classically predisposing to Juvenile myelomonocytic leukemia (JMML) and moyamoya. We describe two affected siblings carrying a paternally inherited CBL variant (c.1210 T> C, p.
Michal Bar‐Hakim, Anat Abramovich, Sara Via‐Dorembus, Gali Heimer, Bruria Ben‐Zeev, Etai Adam, Assaf A. Barg, Jonathan Roth, Basheer Sheick‐Yousif, Rony Beeri Berkowiz, Michal Feldon, Haim Bassan, Moran Hausman‐Kedem   +12 more
wiley   +1 more source

Induction of immune tolerance in NMOSD and MOGAD

Therapeutic Advances in Neurological Disorders
Neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are autoimmune diseases characterized by immune-mediated damage to the central nervous system. Current treatments primarily focus on chronic immunosuppression.
Jorge Correale, Edgar Carnero Contentti
openaire   +4 more sources

Tocilizumab treatment in MOGAD: a case report and literature review [PDF]

Myelin oligodendrocyte glycoprotein-immunoglobulin G associated disease (MOGAD) is an autoimmune demyelinating disorder of the central nervous system (CNS) which usually occurs with recurrent optic neuritis, transverse myelitis, acute disseminating ...
Paolo Ragonese, Giuseppe Salemi, Giuseppe Schirò, Salvatore Iacono, Alessia Bianchi, Michele Andolina   +5 more
core   +1 more source