Results 1 to 10 of about 163,909 (218)

Pathophysiology of myelin oligodendrocyte glycoprotein antibody disease

Frontiers in Neurology, 2023
Myelin Oligodendrocyte Glycoprotein Antibody Disease (MOGAD) is a spectrum of diseases, including optic neuritis, transverse myelitis, acute disseminated encephalomyelitis, and cerebral cortical encephalitis. In addition to distinct clinical, radiological, and immunological features, the infectious prodrome is more commonly reported in MOGAD (37–70 ...
Tanuja Chitnis
exaly   +5 more sources

Antibodies to myelin oligodendrocyte glycoprotein in optic perineuritis. [PDF]

Front Immunol
Introduction This study aimed to investigate the prevalence of myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) in patients with optic perineuritis (OPN) and to analyze the clinical characteristics and prognosis of MOG-IgG–seropositive cases ...
Cao S, Zhang Y, Xu X, Sun M, Pan C, Wang Y, Wei S, Xu Q, Zhou H.   +8 more
europepmc   +6 more sources

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease: A Comparison With Rituximab. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Fan Y, Zhou L, ZhangBao J, Tan H, Wang Z, Quan C.   +5 more
europepmc   +2 more sources

The Structure and Function of Myelin Oligodendrocyte Glycoprotein [PDF]

Journal of Neurochemistry, 1999
Abstract : Myelin oligodendrocyte glycoprotein (MOG) is a quantitatively minor component of CNS myelin whose function remains relatively unknown. As MOG is an autoantigen capable of producing a demyelinating multiple sclerosis‐like disease in mice and rats, much of the research directed toward MOG has been immunological in nature. Although the function
Terrance Johns, Claude C A Bernard
exaly   +3 more sources

Quantitative MRI Uncovers Subtle Cortical Damage in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective To determine whether myelin‐sensitive quantitative MRI reveals microstructural abnormalities in normal‐appearing cortex (NACtx) in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), indicating that conventional MRI underestimates remission residual cortical injury.
Camera V, Tamanti A, Messina S, Dall'Osto N, Maltempo T, Ziccardi S, Foschi M, Piscaglia MG, Ferraro D, Crescenzo F, Rossi F, Bajrami A, Marangoni S, Marastoni D, Pizzini FB, Leite MI, Magliozzi R, Waters P, Calabrese M, Palace J, Geraldes R.   +20 more
europepmc   +2 more sources

Myelin Oligodendrocyte Glycoprotein Encephalomyelitis

Indian Pediatrics Case Reports, 2022
Background: Myelin oligodendrocyte glycoprotein encephalomyelitis (MOG-EM) includes patients with (i) monophasic or relapsing acute optic neuritis, myelitis, brainstem encephalitis, or encephalitis; (ii) magnetic resonance imaging (MRI) or electrophysiological evidence of central nervous system (CNS) demyelination; and (iii ...
Nimrat Sandhu, B M Sunil Kumar
openaire   +3 more sources

Frequency and Characteristics of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease Accompanied by Fever: A Single-Center Retrospective Study. [PDF]

CNS Neurosci Ther
Diagnostic pitfall in fever with CNS involvement: MOGAD. Fever accompanied by neurological symptoms was initially suspected as central nervous system infection. However, negative pathogen tests and failed anti‐infective therapy, followed by positive MOG‐IgG, led to a revised diagnosis of MOGAD. The patient responded favorably to corticosteroids or IVIG.
Guo A, Shi FD, Shi K.
europepmc   +2 more sources

Myelin oligodendrocyte glycoprotein antibodies in genetic leukodystrophies

Journal of Neuroimmunology, 2022
Accumulation of intermediate metabolites due to enzyme deficiencies and demyelination can provoke inflammation in genetic leukodystrophies. Thirty patients with genetic leukodystrophy and 48 healthy control sera were tested for anti-myelin oligodendrocyte glycoprotein (MOG) antibodies by fixed and/or live cell-based assays.
Eroglu-Ertugrul, Nesibe Gevher, Yousefi, Mohammadreza, Pekguel, Faruk, Doran, Tansu, Guenbey, Ceren, Topcu, Meral, Oguz, Kader K., Ozkara, Hatice Asuman, Vural, Atay, Anlar, Banu   +9 more
openaire   +5 more sources

A Molecular Model of Myelin Oligodendrocyte Glycoprotein [PDF]

Journal of Neurochemistry, 1998
Abstract: Myelin oligodendrocyte glycoprotein (MOG) is a protein on the surface of myelin sheaths. It is a putative target of the autoimmune attack in the inflammatory and demyelinating CNS disease multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis.
P, Hjelmström, J E, Penzotti, R M, Henne, T P, Lybrand   +3 more
openaire   +2 more sources

Myelin-oligodendrocyte glycoprotein antibody-associated disease [PDF]

The Lancet Neurology, 2021
Myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a recently identified autoimmune disorder that presents in both adults and children as CNS demyelination. Although there are clinical phenotypic overlaps between MOGAD, multiple sclerosis, and aquaporin-4 antibody-associated neuromyelitis optica spectrum disorder (NMOSD ...
Marignier, Romain, Hacohen, Yael, Cobo-Calvo, Alvaro, Pröbstel, Anne-Katrin, Aktas, Orhan, Alexopoulos, Harry, Amato, Maria-Pia, Asgari, Nasrin, Banwell, Brenda, Bennett, Jeffrey, Brilot, Fabienne, Capobianco, Marco, Chitnis, Tanuja, Ciccarelli, Olga, Deiva, Kumaran, de Sèze, Jérôme, Fujihara, Kazuo, Jacob, Anu, Kim, Ho, Kleiter, Ingo, Lassmann, Hans, Leite, Maria-Isabel, Linington, Christopher, Meinl, Edgar, Palace, Jacqueline, Paul, Friedemann, Petzold, Axel, Pittock, Sean, Reindl, Markus, Sato, Douglas, Selmaj, Krzysztof, Siva, Aksel, Stankoff, Bruno, Tintore, Mar, Traboulsee, Anthony, Waters, Patrick, Waubant, Emmanuelle, Weinshenker, Brian, Derfuss, Tobias, Vukusic, Sandra, Hemmer, Bernhard   +40 more
openaire   +7 more sources