Structural insights into the antigenicity of myelin oligodendrocyte glycoprotein [PDF]
Proceedings of the National Academy of Sciences, 2003 Multiple sclerosis is a chronic disease of the central nervous system (CNS) characterized by inflammation, demyelination, and axonal loss. The immunopathogenesis of demyelination in multiple sclerosis involves an autoantibody response to myelin oligodendrocyte glycoprotein (MOG), a type I transmembrane protein located at the ...
Breithaupt, C. +6 more
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Particular aspects of myelin-axon interactions in health and disease : the expression of myelin-associated glycoprotein isoforms in CNS and PNS. Early axonal pathology in the dysmyelinating peripheral neuropathy CMT1A [PDF]
, 2007 An intact myelin sheath is crucial for the rapid propagation of action potentials along myelinated axons. There are many neurodegenerative diseases associated with defect myelin sheaths resulting in severe clinical symptoms such as multiple sclerosis ...
Flück, Bettina
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Myelin oligodendrocyte glycoprotein antibody-associated disease presenting with posterior scleritis. [PDF]
Oman J OphthalmolThe objective of this article is to describe an unusual presentation of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) with posterior scleritis and optic neuritis.
Al Balushi N, Okrent-Smolar A, Kedar S.
europepmc +2 more sources
Case Reports in Neurological Medicine, 2021 Neuromyelitis optica spectrum disorder (NMOSD) is an immune-mediated inflammatory condition involving spinal cord and optic nerves. Diagnosis of NMOSD is done by aquaporin-4 antibody (AQP4) in patients with optic neuritis.
Sangam Shah +9 more
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Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2019 Background Demyelinating diseases of the central nervous system associated with autoantibodies against aquaporin-4 and myelin-oligodendrocyte-glycoprotein are mediated by different immunopathological mechanisms compared to multiple sclerosis.
Livia S Hofer +13 more
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The AD946 antibody recognizes a 6xHis-tagged recombinant protein by Western blot
Antibody Reports, 2018 The recombinant antibody AD946 detects by Western blot the 6xHis-tagged human myelin oligodendrocyte glycoprotein (MOG).
Otmane Lamrabet, Tania Jauslin
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Transverse myelitis in myelin oligodendrocyte glycoprotein antibody-associated disease
Frontiers in Neurology, 2023 Transverse myelitis (TM) is the second most common presentation of myelin oligodendrocyte antibody-associated disease (MOGAD), occurring in approximately 26% of affected patients.
Gina Perez-Giraldo +2 more
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Myelin oligodendrocyte glycoprotein antibody-associated disease presenting as isolated simultaneous bilateral optic neuritis in a child. [PDF]
Oman J OphthalmolMyelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is the most recently defined distinct demyelinating disorder of the central nervous system which has heterogeneous clinical manifestations.
Singh G, Rahman Z.
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Developmental Expression of the Oligodendrocyte Myelin Glycoprotein in the Mouse Telencephalon [PDF]
Cerebral Cortex, 2009 The oligodendrocyte myelin glycoprotein is a glycosylphosphatidylinositol-anchored protein expressed by neurons and oligodendrocytes in the central nervous system. Attempts have been made to identify the functions of the myelin-associated inhibitory proteins (MAIPs) after axonal lesion or in neurodegeneration.
Gil Fernández, Vanessa +11 more
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Arquivos de Neuro-Psiquiatria, 2023 Background Anti-myelin oligodendrocyte glycoprotein (anti-MOG) antibody-associated disease (MOGAD) is an immune-mediated neurological disorder with a broad spectrum of clinical presentation that is often difficult to distinguish from other ...
Katharina Messias +6 more
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