Results 51 to 60 of about 163,909 (218)

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source

Myelin oligodendrocyte glycoprotein antibody-associated optic neuritis: an update

, 2022
Myelin oligodendrocyte glycoprotein-immunoglobulin G (IgG)-associated optic neuritis has been established as a new entity of immune-mediated optic neuropathy. Patients usually present with recurrent optic neuritis, often bilaterally with initially severe
Vanessa Daccach Marques (5645420), Katharina Messias (5765279), Andre Messias (198395)   +2 more
core   +1 more source

Endogenous Activation of mGlu5 Metabotropic Glutamate Receptors Is Required for Oligodendrocyte Maturation and Myelinogenesis in Mice

Cells
mGlu5 metabotropic glutamate receptors are highly expressed and functional in early postnatal life, but their role in brain development remains to be elucidated.
Roxana Paula Ginerete, Roberta Facchinetti, Alessia Ceccherelli, Giada Mascio, Sara Rubio Casado, Luisa Di Menna, Sonia Castaldi, Matteo Caridi, Valeria Bruno, Ferdinando Nicoletti, Giuseppe Battaglia, Caterina Scuderi, Rosamaria Orlando   +12 more
doaj   +1 more source

Clinical and Modifiable Factors Associated With Disability and Relapse in MOGAD: A Multicentre Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Factors associated with relapse course and disability in myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) remain incompletely understood. Objectives To identify clinical and modifiable factors associated with relapse and disability in MOGAD. Methods In this ambispective multicentre cohort study using data from
Yingtao Wang, Shaoxin Tao, Qiujia Wang, Xiaoyu Xu, Hui Yao, Zheng Liu, Dawei Li, Zhandong Qiu, Jinming Han, Jiangwei Xia, Qi Wang, Jun Sun, Kai Shao, Jiao Li, Shishuang Ruan, Yi Zhong, Jun Guo, Shougang Guo, Yue Huang, Guoliang Chai, Tao Jin, Hongyu Zhou, Junwei Hao, Yinan Zhao   +23 more
wiley   +1 more source

Molecular mechanisms underlying Mash1 function in oligodendrogenesis [PDF]

, 2010
Members of the basic helix-loop-helix (bHLH) proneural family of proteins, including Mash1, are crucial transcription factors (TFs) in neurogenesis. More recently, a role for Mash1 in the specification of oligodendrocyte precursor cells (OPCs) has been ...
Galiñanes García, L.
core  

Myelin oligodendrocyte glycoprotein antibody-associated optic neuritis: an update

, 2023
Myelin oligodendrocyte glycoprotein-immunoglobulin G (IgG)-associated optic neuritis has been established as a new entity of immune-mediated optic neuropathy. Patients usually present with recurrent optic neuritis, often bilaterally with initially severe
Vanessa Daccach Marques (5645420), Katharina Messias (5765279), Andre Messias (198395)   +2 more
core   +1 more source

Relapsing MRI-negative myelitis associated with myelin-oligodendrocyte glycoprotein autoantibodies: a case report

BMC Neurology, 2022
Background Serum antibodies to myelin-oligodendrocyte glycoprotein (MOG) are biomarkers of MOG-IgG-associated disorder (MOGAD), a demyelinating disease distinct from both multiple sclerosis and aquaporin-4-IgG neuromyelitis optica spectrum disorder.
Jan Kolcava, Aneta Rajdova, Eva Vlckova, Pavel Stourac, Josef Bednarik   +4 more
doaj   +1 more source

Comparative Analysis of Choroid Plexus Volume Between MOG Antibody Associated Disease and Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Choroid plexus volume (CPV) has been proposed as a neuro‐immunological marker of multiple sclerosis (MS), but its relevance in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) remains uncertain. We analyzed CPV in 43 individuals with MOGAD, 48 with MS, and 44 healthy controls using a Bayesian Gaussian mixture modeling ...
Jae‐Won Hyun, Shaun G. Hong, Na Young Park, Su‐Hyun Kim, Ho Jin Kim   +4 more
wiley   +1 more source

Acute urinary retention as first sign of myelin oligodendrocyte glycoprotein antibody disease (MOGAD) - Case report and literature review

Urology Case Reports
Myelin oligodendrocyte glycoprotein antibody disease is a rare, demyelinating condition of the central nervous system. We report a case of a male presenting with acute urinary retention and brainstem lesion, highlighting an atypical initial manifestation
Mariana Dias Capinha, Andreia Cardoso, Catarina Tinoco, Ana Sofia Araújo, Luís Pinto, Aparício Coutinho, Emanuel Dias, Miguel Mendes   +7 more
doaj   +1 more source

Bilateral optic neuritis as a presentation of myelin oligodendrocyte glycoprotein antibody associated disease in a child

Indian Journal of Ophthalmology. Case Reports, 2023
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), although rare, is now recognized as a distinct demyelinating disorder. The entity differs from multiple sclerosis and neuromyelitis optica spectrum disorder in terms of clinical ...
Sai Lakshmi Raghavan, Rajesh Prabu, Shruti Mohan, Suruthi Nagarajan   +3 more
doaj   +1 more source