Results 101 to 110 of about 385,028 (263)
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Breeding Aromatic Rice Restorer by Specific Fragrant Molecular Marker-assisted Selection [PDF]
, 2015 水稻是最重要的粮食作物之一，香稻因其米饭清香、口感好以及市场价格高等优势而倍受人们青睐。由于传统香稻品种大多产量低、抗性弱且有地域性限制，导致其推广种植面积受到限制；而且传统的香稻育种方式耗时长、准确率低，使香稻品种的开发缓慢低效。随着分子生物技术的飞速发展，借助分子标记辅助选择开展香稻育种可以提高香味选择准确率，加快育种进程。为此，本研究应用分子标记辅助选择技术与传统育种技术相结合的方法，选用优良水稻恢复系福恢673、明恢86和闽恢3301为受体亲本，分别与香味基因供体亲本优质香稻品种象牙香占杂交 ...
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Application progress of DNA molecular markers in non-heading Chinese cabbage genetic breeding
上海师范大学学报. 自然科学版, 2017 This paper reviews the classification and characteristics of DNA molecular markers in non-heading Chinese cabbage (Brassica campestris ssp. chinensis Makino) genetic breeding,and its application in genetics diversity analysis,genetic map construction ...
Li Mengmeng +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Applied Genetics and Genomics in Alfalfa Breeding
Agronomy, 2012 Alfalfa (Medicago sativa L.), a perennial and outcrossing species, is a widely planted forage legume for hay, pasture and silage throughout the world. Currently, alfalfa breeding relies on recurrent phenotypic selection, but alternatives incorporating ...
E. Charles Brummer, Xuehui Li
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
The application of modern molecular techniques in animal selection [PDF]
Biotechnology in Animal Husbandry, 2018 Some problems of modern analysis of the genome of domestic animals and the possibility of applying the results of the research in the selection have considered. Molecular genome analysis has progressed rapidly.
Petrović Milan P. +6 more
doaj
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source