Results 111 to 120 of about 385,028 (263)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

DNA Testing Methodology for the Evaluation of Susceptibility to Scrapie in Tsurcana Sheep

Scientific Papers Animal Science and Biotechnologies
Scrapie, first reported in the 18th century, has led to considerable economic losses by affecting the livestock industry. This disease is a transmissible spongiform encephalopathy that mainly affects sheep and goats and is caused by the accumulation of ...
Dana-Iuliana Neață, Maria-Mihaela Antofie, Teodor Vintilă   +2 more
doaj  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Resonant Magnetization Tunneling in Mn12 Acetate: The Absence of Inhomogeneous Hyperfine Broadening

, 1998
We present the results of a detailed study of the thermally-assisted-resonant-tunneling relaxation rate of Mn12 acetate as a function of an external, longitudinal magnetic field and find that the data can be fit extremely well to a Lorentzian function ...
A. Caneschi, A. Fort, A. Garg, A. L. Barra, A. L. Burin, A. M. Gomes, B. Barbara, C. Paulsen, C. Paulsen, C. Sangregorio, D. A. Garanin, D. A. Garanin, D. Ruiz, E. M. Chudnovsky, E. M. Chudnovsky, F. Hartmann-Boutron, F. Lionti, F. Luis, F. Luis, J. A. A. J. Perenboom, J. L. van Hemmen, J. L. van Hemmen, J. M. Hernández, J. M. Hernández, J. R. Friedman, J. R. Friedman, J. R. Friedman, J. R. Friedman, J. Villain, Jonathan R. Friedman, L. Gunther, L. Thomas, M. A. Novak, M. Enz, M. P. Sarachik, N. V. Prokof’ev, N. V. Prokof’ev, R. Sessoli, R. Ziolo, S. Hill, S. M. J. Aubin, S. M. J. Aubin, T. Lis, V. V. Dobrovitski   +43 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Perspectives from agriculture: advances in livestock breeding - implications for aquaculture genetics [PDF]

, 2006
In this paper we present livestock breeding developments that could be taken into consideration in the genetic improvement of farmed aquaculture species, especially in freshwater fish.
Nguyen, N.H., Ponzoni, R.W.
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Effectiveness of applying different methods of molecular genetics in swine selection (A review)

Животновъдни науки, 2023
The rapid development of molecular genetics in the last two decades, primarily related to the technological breakthrough in the field of genome sequencing of higher organisms, has made it possible to apply new models of work.
Katya Eneva, Apostol Apostolov
doaj  

Study of inheritance and identification of QTLs linked to Ceratocystis wilt resistance in cacao [PDF]

, 2012
Ceratocystis wilt (CW) in cacao, caused by Ceratocystis cacaofunesta, is a drastic disease that results in plant death. The pathogen was recently identified in the major cacao-producing region of Brazil-Bahia.
Clément, Didier, Ferreira Santos, Rogério Mercês, Lopes, Uilson Vanderlei, Micheli, Fabienne, Peres Gramacho, Karina, Vieira Midlej Silva, Stela Dalva   +5 more
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source