Results 41 to 50 of about 7,530,679 (394)
Clinical update on head and neck cancer: molecular biology and ongoing challenges
Cell Death and Disease, 2019 Head and neck squamous cell carcinomas (HNSCCs) are an aggressive, genetically complex and difficult to treat group of cancers. In lieu of truly effective targeted therapies, surgery and radiotherapy represent the primary treatment options for most ...
E. Alsahafi +6 more
semanticscholar +1 more source
Molecular Biology of Aging [PDF]
Cell, 1999 1. The Human Mitochondrion and Pathophysiology of Aging and Age-related Diseases D.C. Wallace 2. Sirtuins: A Universal Link between NAD, Metabolism, and Aging S.-i. Imai and L. P. Guarente 3. Calorie Restriction in Lower Organisms S.L. Helfand, J.H. Bauer, and J.G. Wood 4. Evolutionary Theory in Aging Research S.N. Austad and T.B.L. Kirkwood 5.
David A. Sinclair +2 more
openaire +3 more sources
miR-29cb2 promotes angiogenesis and osteogenesis by inhibiting HIF-3α in bone
iScience, 2022 Summary: Coordination between osteogenesis and angiogenesis is required for bone homeostasis. Here, we show that miR-29cb2 is a bone-specific miRNA and plays critical roles on angiogenesis-osteogenesis coupling during bone remodeling.
Liping Ouyang +12 more
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Ten Simple Rules for Creating Biomolecular Graphics [PDF]
PLoS Computational Biology (2010), 6(8): e1000918, 2014 One need only compare the number of three-dimensional molecular illustrations in the first (1990) and third (2004) editions of Voet & Voet's "Biochemistry" in order to appreciate this field's profound communicative value in modern biological sciences -- ranging from medicine, physiology, and cell biology, to pharmaceutical chemistry and drug design, to
arxiv +1 more source
Molecular biology of myeloma [PDF]
Clinical and Translational Oncology, 2007 Multiple myeloma (MM) is a B-cell malignancy characterised by the accumulation of clonal plasma cells (PC) in the bone marrow (BM). The molecular bases for this incurable disease have been widely investigated in the last years, and the development of modern genomic technologies has contributed to the understanding of the pathogenesis of MM.
Gutiérrez, Norma Carmen +2 more
openaire +3 more sources
The endocytosis of oxidized LDL via the activation of the angiotensin II type 1 receptor
iScience, 2021 Summary: Arrestin-dependent activation of a G-protein-coupled receptor (GPCR) triggers endocytotic internalization of the receptor complex. We analyzed the interaction between the pattern recognition receptor (PRR) lectin-like oxidized low-density ...
Toshimasa Takahashi +23 more
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Rhabdomyosarcoma: Advances in Molecular and Cellular Biology. [PDF]
, 2015 Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in childhood and adolescence. The two major histological subtypes of RMS are alveolar RMS, driven by the fusion protein PAX3-FKHR or PAX7-FKHR, and embryonic RMS, which is usually ...
Duan, Zhenfeng +5 more
core +3 more sources
Cells, 2019 Glioblastoma multiforme is the most aggressive malignant tumor of the central nervous system. Due to the absence of effective pharmacological and surgical treatments, the identification of early diagnostic and prognostic biomarkers is of key importance ...
A. Silantyev +9 more
semanticscholar +1 more source
Population Ecology, EarlyView.In this study, we compared three methods for kinship identification using different algorithms in samples of wild Pacific bluefin tuna and generated genotyping data. The three methods resulted in different numbers of inferred kinship pairs for both generated and actual data. Particularly for the half‐sibling pairs, considerable number of false‐positive
Yohei Tsukahara +5 more
wiley +1 more source
iScience, 2021 Summary: Protein arginine methyltransferases (PRMTs) catalyze the post-translational monomethylation (Rme1), asymmetric (Rme2a), or symmetric (Rme2s) dimethylation of arginine. To determine the cellular consequences of type I (Rme2a) and II (Rme2s) PRMTs,
Maxim I. Maron +17 more
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