Results 41 to 50 of about 6,277,513 (247)

RPRM negatively regulates ATM levels through its nuclear translocation on irradiation mediated by CDK4/6 and IPO11

iScience, 2022
Summary: How the ataxia telangiectasia mutated (ATM) protein kinase, a core protein in DNA damage response, is regulated at post-transcription level remains unclear.
Yarui Zhang, Guomin Ou, Zhujing Ye, Zhou Zhou, Qianlin Cao, Mengting Li, Jingdong Wang, Jianping Cao, Hongying Yang   +8 more
doaj   +1 more source

Phosphate-induced activation of VEGFR2 leads to caspase-9-mediated apoptosis of hypertrophic chondrocytes

iScience, 2023
Summary: Low circulating phosphate (Pi) leads to rickets, characterized by expansion of the hypertrophic chondrocytes (HCs) in the growth plate due to impaired HC apoptosis.
Prem Swaroop Yadav, Garyfallia Papaioannou, Margaret M. Kobelski, Marie B. Demay   +3 more
doaj   +1 more source

Protocol for generating mutant zebrafish using CRISPR-Cas9 followed by quantitative evaluation of vascular formation

STAR Protocols, 2023
Summary: The use of vascular-specific transgenic zebrafish provides advantages for identifying new mutations affecting angiogenesis and vascular development.
Juanjuan Luo, Chunjiao Lu, Maya Wang, Xiaojun Yang   +3 more
doaj   +1 more source

The endocytosis of oxidized LDL via the activation of the angiotensin II type 1 receptor

iScience, 2021
Summary: Arrestin-dependent activation of a G-protein-coupled receptor (GPCR) triggers endocytotic internalization of the receptor complex. We analyzed the interaction between the pattern recognition receptor (PRR) lectin-like oxidized low-density ...
Toshimasa Takahashi, Yibin Huang, Koichi Yamamoto, Go Hamano, Akemi Kakino, Fei Kang, Yuki Imaizumi, Hikari Takeshita, Yoichi Nozato, Satoko Nozato, Serina Yokoyama, Motonori Nagasawa, Tatsuo Kawai, Masao Takeda, Taku Fujimoto, Kazuhiro Hongyo, Futoshi Nakagami, Hiroshi Akasaka, Yoichi Takami, Yasushi Takeya, Ken Sugimoto, Herbert Y. Gaisano, Tatsuya Sawamura, Hiromi Rakugi   +23 more
doaj   +1 more source

Molecular Biology of Aging [PDF]

Cell, 1999
1. The Human Mitochondrion and Pathophysiology of Aging and Age-related Diseases D.C. Wallace 2. Sirtuins: A Universal Link between NAD, Metabolism, and Aging S.-i. Imai and L. P. Guarente 3. Calorie Restriction in Lower Organisms S.L. Helfand, J.H. Bauer, and J.G. Wood 4. Evolutionary Theory in Aging Research S.N. Austad and T.B.L. Kirkwood 5.
David A. Sinclair, Leonard Guarente, F. Brad Johnson   +2 more
openaire   +3 more sources

Clinical update on head and neck cancer: molecular biology and ongoing challenges

Cell Death and Disease, 2019
Head and neck squamous cell carcinomas (HNSCCs) are an aggressive, genetically complex and difficult to treat group of cancers. In lieu of truly effective targeted therapies, surgery and radiotherapy represent the primary treatment options for most ...
E. Alsahafi, K. Begg, I. Amelio, N. Raulf, P. Lucarelli, T. Sauter, M. Tavassoli   +6 more
semanticscholar   +1 more source

Plant Molecular Biology Databases

Highlights in BioScience, 2019
Many plant biological database comprises data from study fields including metabolomics, proteomics, genomics, microarray gene expression, and phylogenetic. Information in biological databases involves the role of genes, composition, chromosomal location,
Zubair Awan, Aqib Ali, Abbas Iqbal
doaj   +1 more source

miR-29cb2 promotes angiogenesis and osteogenesis by inhibiting HIF-3α in bone

iScience, 2022
Summary: Coordination between osteogenesis and angiogenesis is required for bone homeostasis. Here, we show that miR-29cb2 is a bone-specific miRNA and plays critical roles on angiogenesis-osteogenesis coupling during bone remodeling.
Liping Ouyang, Yingxiao Sun, Dan Lv, Xiaochun Peng, Xiaoming Liu, Lei Ci, Guoning Zhang, Bo Yuan, Ling Li, Jian Fei, Jun Ma, Xuanyong Liu, Yun Liao   +12 more
doaj   +1 more source

mTORC2 regulates auditory hair cell structure and function

iScience, 2023
Summary: mTOR broadly controls cell growth, but little is known about the role of mTOR complex 2 (mTORC2) in the inner ear. To investigate the role of mTORC2 in sensory hair cells (HCs), we generated HC-specific Rictor knockout (HC-RicKO) mice.
Maurizio Cortada, Soledad Levano, Michael N. Hall, Daniel Bodmer   +3 more
doaj   +1 more source

Current and Future Trends on Diagnosis and Prognosis of Glioblastoma: From Molecular Biology to Proteomics

Cells, 2019
Glioblastoma multiforme is the most aggressive malignant tumor of the central nervous system. Due to the absence of effective pharmacological and surgical treatments, the identification of early diagnostic and prognostic biomarkers is of key importance ...
A. Silantyev, L. Falzone, M. Libra, O. Gurina, K. Kardashova, T. Nikolouzakis, A. Nosyrev, Christopher Sutton, P. Mitsias, A. Tsatsakis   +9 more
semanticscholar   +1 more source