Results 81 to 90 of about 6,277,513 (247)

The Molecular Biology of Coronaviruses

open access: yes, 1983
Coronaviruses have recently emerged as an important group of animal and human pathogens that share a distinctive replicative cycle. Some of the unique characteristics in the replication of coronaviruses include generation of a 3' coterminal-nested set of five or six subgenomic mRNAs, each of which appears to direct the synthesis of one protein.
Kathryn V. Holmes, Lawrence S. Sturman
openaire   +3 more sources

Proteasome assembly chaperone translation upon stress requires Ede1 phase separation at the plasma membrane

open access: yesiScience
Summary: Proteome adaptation is key to cells surviving stresses. Increased translation of proteasome assembly chaperones (PACs) is critical for increasing proteasome assembly and cell degradative capacity.
Thomas D. Williams   +3 more
doaj   +1 more source

Phosphorylation of Optineurin by protein kinase D regulates Parkin-dependent mitophagy

open access: yesiScience
Summary: Degradation of damaged mitochondria, a process called mitophagy, plays a role in mitochondrial quality control and its dysfunction has been linked to neurodegenerative pathologies.
Robert Weil   +7 more
doaj   +1 more source

Lysosomal stress drives the release of pathogenic α-synuclein from macrophage lineage cells via the LRRK2-Rab10 pathway

open access: yesiScience
Summary: α-Synuclein and LRRK2 are associated with both familial and sporadic Parkinson’s disease (PD), although the mechanistic link between these two proteins has remained elusive.
Tetsuro Abe   +5 more
doaj   +1 more source

MMP9 drives ferroptosis by regulating GPX4 and iron signaling

open access: yesiScience
Summary: Ferroptosis, defined by the suppression of glutathione peroxidase-4 (GPX4) and iron overload, is a distinctive form of regulated cell death.
Flobater I. Gawargi, Paras K. Mishra
doaj   +1 more source

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