Results 81 to 90 of about 7,530,679 (394)
FEBS Letters, EarlyView.The mitochondrial outer membrane iron–sulphur ([Fe‐S]) protein mitoNEET is a target of the type‐2 diabetes drug pioglitazone. Its unknown molecular function is linked to respiratory complex activity and mitochondrial function. We discovered that O2 protects the mitoNEET [2Fe‐2S] cluster against NO oxidation and desensitization towards reduction by H2S.
Thao Nghi Hoang +9 more
wiley +1 more source
Computing Pathways to Systems Biology: Key Contributions of Computational Methods in Pathway Identification [PDF]
arXiv, 2013 Understanding large molecular networks consisting of entities such as genes, proteins or RNAs that interact in complex ways to drive the cellular machinery has been an active focus of systems biology. Computational approaches have played a key role in systems biology by complementing theoretical and experimental approaches.
arxiv
Evaluating the Potential of Leading Large Language Models in Reasoning Biology Questions [PDF]
arXiv, 2023 Recent advances in Large Language Models (LLMs) have presented new opportunities for integrating Artificial General Intelligence (AGI) into biological research and education. This study evaluated the capabilities of leading LLMs, including GPT-4, GPT-3.5, PaLM2, Claude2, and SenseNova, in answering conceptual biology questions.
arxiv
Developing Predictive Molecular Maps of Human Disease through Community-based Modeling [PDF]
, 2011 The failure of biology to identify the molecular causes of disease has led to disappointment in the rate of development of new medicines. By combining the power of community-based modeling with broad access to large datasets on a platform that promotes ...
Christine Suver +10 more
core +2 more sources
The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders.
Endocrine reviews, 2011 Steroidogenesis entails processes by which cholesterol is converted to biologically active steroid hormones. Whereas most endocrine texts discuss adrenal, ovarian, testicular, placental, and other steroidogenic processes in a gland-specific fashion ...
W. Miller, R. Auchus
semanticscholar +1 more source
The Application of Molecular Biology [PDF]
Current Issues in Molecular Biology, 1999 Molecular biology methods have tremendous value not only in the investigation of basic scientific questions, but also in application to a wide variety of problems affecting the overall human condition. Disease prevention and treatment, generation of new protein products, and manipulation of plants and animals for desired phenotypic traits are all ...
openaire +3 more sources
Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase
FEBS Letters, EarlyView.Here, we performed a functional analysis of the fungal enzymes belonging to clade D of the β‐class carbonic anhydrase family (β‐D‐CA). The β‐D‐CAs in the basidiomycete Gloeophyllum trabeum and the ascomycete Trichoderma harzianum showed very low activity in the hydration of CO2 but exhibited high activity in the hydrolysis of carbonyl sulfide (COS ...
Ryuka Iizuka +6 more
wiley +1 more source
Concerns regarding the deterioration of objectivity in molecular biology [PDF]
arXiv, 2018 Scientific objectivity was not a problem in the early days of molecular biology. However, relativism seems to have invaded some areas of the field, damaging the objectivity of its analyses. This review reports on the status of this issue by investigating a number of cases.
arxiv
The biochemistry and molecular biology of chlorophyll breakdown
Journal of Experimental Botany, 2018 Chlorophyll breakdown is one of the most obvious signs of leaf senescence and fruit ripening. The resulting yellowing of leaves can be observed every autumn, and the color change of fruits indicates their ripening state.
B. Kuai, Junyi Chen, S. Hörtensteiner
semanticscholar +1 more source
Molecular biology of erythropoietin
Kidney International, 1993 A 42-year-old man presented with hypertension and proteinuria 22 years ago and was found to have adult polycystic kidney disease. Within 8 years he was approaching end-stage renal failure (creatinine clearance, 10 mI/mm). The hemoglobin (Hb) was 10.0 g/dl. Hemodialysis was initiated 13 years ago, when his Hb was 6.6 g/dl. Two months later, it had risen
openaire +3 more sources