Results 91 to 100 of about 3,587,617 (298)

Microfluidics for protein biophysics [PDF]

, 2018
Microfluidics has the potential to transform experimental approaches across the life sciences. In this review, we discuss recent advances enabled by the development and application of microfluidic approaches to protein biophysics. We focus on areas where
Charmet, Jérôme, Knowles, P. J. Knowles, Arosio, Paolo   +2 more
core   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

All-Optical Sensing of the Components of the Internal Local Electric Field in Proteins

IEEE Photonics Journal, 2012
Here, we present a new all-optical method of interrogation of the internal electric field vector inside proteins. The method is based on experimental evaluation of the permanent dipole moment change upon excitation and the pure electronic transition ...
M. Drobizhev, J. N. Scott, P. R. Callis, A. Rebane   +3 more
doaj   +1 more source

Molecular Biophysics Symposium, November 6, 2014

, 2014
Virginia Tech hosted the first Molecular Biophysics Symposium focusing on structural biology studies of proteins. The event pursued two goals. First, it was designed to enrich the interaction among biophysical research groups located in southwest ...
Capelluto, Daniel G. S.
core  

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

SYSTEMIC APPROACH TO TEACHING BIOPHYSICS TO STUDENTS OF MEDICAL INSTITUTIONS OF HIGHER EDUCATION

Неперервна професійна освіта: теорія та практика
The theoretical part of the study analyzes the content of the principle of systematicity as a method of scientific research of complex systems, on the one hand, and as a principle of learning in combination with other didactic principles, on the other ...
Anatolii Yehorenkov
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Algorithmic Challenges in Computational Molecular Biophysics

Journal of Computational Physics, 1999
Computational techniques for modeling large biological molecules have emerged rapidly in recent years as an important complement to experiment. Computer-generated models and simulation data are essential for analyzing structural and kinetic details that are difficult to capture experimentally for large, floppy macromolecules in solution.
Schlick, Tamar, Skeel, Robert D., Brunger, Axel T., Kalé, Laxmikant V., Board, John A. jun., Hermans, Jan, Schulten, Klaus   +6 more
openaire   +2 more sources

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source