Results 81 to 90 of about 191,889 (301)
Biosurface and Biotribology, 2018 The immune response to ultra-high molecular weight polyethylene wear debris is thought to be one of the major causes of osteolysis and aseptic loosening.
Weiqi Shen +3 more
doaj +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Molecular Biophysics Symposium, November 6, 2014 [PDF]
, 2014 Virginia Tech hosted the first Molecular Biophysics Symposium focusing on structural biology studies of proteins. The event pursued two goals. First, it was designed to enrich the interaction among biophysical research groups located in southwest ...
Capelluto, Daniel G. S.
core
Molecules, 2023 Amyloid aggregates arise from either the partial or complete loss of the native protein structure or the inability of proteins to attain their native conformation. These aggregates have been linked to several diseases, including Alzheimer’s, Parkinson’s,
Gabriel Zazeri +4 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
The Problem with Inventing Molecular Mechanisms to Fit Thermodynamic Equations of Muscle [PDF]
, 2023 Almost every model of muscle contraction in the literature to date is a molecular power stroke model, even though this corpuscular mechanism is opposed by centuries of science, by 85 years of unrefuted evidence that muscle is a thermodynamic system, and ...
Josh Baker
core +1 more source
Production of recombinant collagen: state of the art and challenges
Engineering Biology, 2017 Collagen, which is often used in healthcare materials and biomedical research, is largely extracted from animal sources. Recombinant human collagen has the potential to be a promising alternative to animal collagen which has many shortcomings, including ...
Tianyi Wang +4 more
doaj +1 more source
Engineering Biology, 2020 Inducible genetic switches based on tyrosine recombinase-based DNA excision are a promising platform for the regulation and control of chimeric antigen receptor (CAR) T cell activity in cancer immunotherapy. These switches exploit the increased stability
Jack E. Bowyer +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Hackathons for biophysics education: simulating the cytoskeleton [PDF]
Hackathons are intensive innovation-oriented events where participants work in teams to solve problems or create projects in as little as 24 or 48 hours. These events are common in startup culture, open source communities and mainstream industry. Here we
Zimmer, Patrick +7 more
core +1 more source