Results 61 to 70 of about 191,889 (301)

Advances in Terahertz Biophysics and Chemistry

Research
As terahertz (THz) science and technology continue to advance, THz biophysics and chemistry have emerged as a pivotal interface, linking molecular-scale insights with transformative innovations in biological, physical, and chemical sciences.
Zhi Zhu, Tianqi Wang, Huayan Yang, Junquan Zhu, Joseph S. Francisco, Chunlei Wang   +5 more
doaj   +1 more source

Deciphering the Gene Regulatory Landscape Encoded in DNA Biophysical Features

iScience, 2019
Summary: Gene regulation in higher organisms involves a sophisticated interplay between genetic and epigenetic mechanisms. Despite advances, the logic in selective usage of certain genomic regions as regulatory elements remains unclear. Here we show that
Abhijeet Pataskar, Willem Vanderlinden, Johannes Emmerig, Aditi Singh, Jan Lipfert, Vijay K. Tiwari   +5 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Machine learning-driven protein engineering: a case study in computational drug discovery

Engineering Biology, 2020
Research and development in drug discovery will need to find significant efficiency gains if the industry is to continue generating novel drugs. There is great expectation for machine learning (ML) to provide this boost in R&D productivity, but to ...
Harry F. Rickerby, Katya Putintseva, Christopher Cozens   +2 more
doaj   +1 more source

Protein cages as building blocks for superstructures

Engineering Biology, 2021
Proteins naturally self‐assemble to function. Protein cages result from the self‐assembly of multiple protein subunits that interact to form hollow symmetrical structures with functions that range from cargo storage to catalysis. Driven by self‐assembly,
Ruoxuan Sun, Sierin Lim
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Genomic and Biochemical Analysis of N Glycosylation in the Mushroom-Forming Basidiomycete Schizophyllum commune [PDF]

, 2009
N-linked glycans of Schizophyllum commune consist of Man(5-9)GlcNAc(2) structures. Lack of further glycan maturation is explained by the absence of genes encoding such functions in this and other homobasidiomycetes.
de Jong, J.F., Jong, J.F., de, Wosten, H.A.B., Ohm, R.A., Bosch, G.B.M., van den, Molecular Microbiology, Lugones, L.G., Sub Molecular Microbiology, van den Bosch, G.B.M., Sub Membrane Biochemistry & Biophysics, Rouwendal, G.J.A., Bosch, D., Dep Scheikunde, Berends, E., Membrane Enzymology   +14 more
core   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Molecular Mechanism of Food-Derived Polyphenols on PD-L1 Dimerization: A Molecular Dynamics Simulation Study [PDF]

, 2021
In cancer immunotherapy, an emerging approach is to block the interactions of programmed cell death-1 (PD-1) and programmed cell death-ligand 1 (PD-L1) using small-molecule inhibitors.
Yulong Jin, Jianhuai Liang, Yan Guo, Boping Liu   +3 more
core   +1 more source

Supramolecular Aggregates: Hardness Plus Softness

Molecules, 2021
The properties of supramolecular aggregates cross several disciplines, embracing the sciences of nature and joining theory, experiment, and application.
Lia Queiroz do Amaral
doaj   +1 more source