Results 121 to 130 of about 191,889 (301)
Unveiling islet heterogeneity using an automated microfluidic imaging system
Scientific ReportsIslets of Langerhans are a therapeutic target for diabetes and prediabetes. Measurements of therapeutic inhibitory or excitatory concentrations are often performed using large groups of islets, however, the population heterogeneity cannot be observed ...
James Thornham +2 more
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Long-range order and short-range disorder in Saccharomyces cerevisiae biofilm
Engineering Biology, 2019 Biofilm, a colony forming cooperative response of microorganisms under environmental stress, is a major concern for food safety, water safety and drug resistance. Most current works focus on controlling biofilm growth by targeting single genes. Here, the
Vincent Piras +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
The molecular biophysics of extracellular vimentin and its role in pathogen-host interactions. [PDF]
Curr Opin Cell Biol, 2023 Parvanian S +3 more
europepmc +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Mechanistic modelling of a recombinase-based two-input temporal logic gate
Engineering Biology, 2017 Site-specific recombinases (SSRs) mediate efficient manipulation of DNA sequences in vitro and in vivo. In particular, serine integrases have been identified as highly effective tools for facilitating DNA inversion, enabling the design of genetic ...
Jack E. Bowyer +3 more
doaj +1 more source
Algorithmic Challenges in Computational Molecular Biophysics
Journal of Computational Physics, 1999 Computational techniques for modeling large biological molecules have emerged rapidly in recent years as an important complement to experiment. Computer-generated models and simulation data are essential for analyzing structural and kinetic details that are difficult to capture experimentally for large, floppy macromolecules in solution.
Schlick, Tamar +6 more
openaire +2 more sources
Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz +3 more
wiley +1 more source
Thermofluidic chip containing virtual thermal wells
Engineering Biology, 2019 The authors describe a thermofluidic chip on which microscale islands of controlled temperature are formed within an open fluidic environment. The chip forms part of the authors’ technology for thermally controlled DNA synthesis, whereby the site ...
Andrew J. Ferguson +6 more
doaj +1 more source
New Insights into Vibrio cholerae Biofilms from Molecular Biophysics to Microbial Ecology. [PDF]
Adv Exp Med Biol, 2023 Tai JB, Ferrell MJ, Yan J, Waters CM.
europepmc +1 more source