Results 131 to 140 of about 318,972 (299)

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source

Development of a Synthetic Hydrogel to Foster Microvascularization of an Endometriosis Microphysiological System

Advanced Healthcare Materials, EarlyView.
ABSTRACT The ascent of novel alternative methods in drug development spotlights the dual needs for improved biological fidelity to in vivo, along with reproducibility, especially in regulatory applications. The need for pre‐clinical models of patient‐derived endometriosis lesions motivates the development of a vascularizable, completely synthetic ...
Lauren Pruett, Laura Bahlmann, Ryan Ogi, Angela Jiao, Priyatanu Roy, Matthew Johnson, David Trumper, Linda Griffith   +7 more
wiley   +1 more source

Tuning the Testicular Microenvironment for Enhancing Human Sertoli Cells Maturation and Functionality In Vitro

Advanced Healthcare Materials, EarlyView.
An in vitro testicular model is developed by generating connective tissue equivalents from human dermal fibroblast‐derived microtissues and coupling them with human Sertoli cells or human Sertoli cell spheroids. This engineered microenvironment supports Sertoli cell maturation and functionality, providing a promising platform for studying human ...
Annachiara Scalzone, Giorgia Imparato, Chiara Ausilio, Valentina Mollo, Paolo Antonio Netti   +4 more
wiley   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

Microengineered Gradient Hydrogels for Mechanobiology

Advanced Healthcare Materials, EarlyView.
Gradient hydrogels are used to mimic the mechanical heterogeneity in native tissues, offering powerful in vitro platforms to study cell‐material interactions in diverse pathophysiological contexts. Here, we present a comprehensive review of the design and experimental considerations for stiffness gradient hydrogels, discussing exemplary achievements ...
Shin Wei Chong, Deepu Ashok, Anna Waterhouse, Marcela M. M. Bilek, Daniele Vigolo   +4 more
wiley   +1 more source

Single-molecule experiments in biological physics: methods and applications

, 2006
I review single-molecule experiments (SME) in biological physics. Recent technological developments have provided the tools to design and build scientific instruments of high enough sensitivity and precision to manipulate and visualize individual ...
, , , , , Adachi K, Adelman K, Ahsan A, Alberts B, Allahverdyan A, Allemand J F, Altan-Bonnet G, Ashkin A, Ashkin A, Ashkin A, Ashkin A, Ashkin A, Ashkin A, Astumian R D, Astumian R D, Baumann C G, Baumann C G, Bell G I, Bennett C H, Bennink M L, Bennink M L, Bensimon D, Best R B, Bhasin N, Bhattacharjee S M, Bhattacharjee S M, Binnig G, Binnig G, Blanchard S C, Blickle V, Block S M, Block S M, Bloomfield V A, Bochkov G N, Bockelmann U, Boroudjerdi H, Bouchiat C, Braslavsky I, Brower-Toland B D, Brujic J, Bryant Z, Bundschuh R, Burgess S A, Bustamante C, Bustamante C, Bustamante C, Bustamante C, Calladine C R, Carl P, Carrion-Vazquez M, Carrion-Vazquez M, Carrion-Vazquez M, Carter N J, Carter N J, Causo M S, Charvin G, Chatenay D, Chen S-J, Ciliberto S, Clausen-Schaumann H, Cluzel P, Cocco S, Cocco S, Cocco S, Cocco S, Cocco S, Cohen E G D, Cohen E G D, Cohen E G D, Crooks G E, Crooks G E, Cross R A, Cuesta-Lopez S, Cui Y, Cui Y, Cule D, Czajkowsky D M, Córdova N J, Daban J R, Dammer U, Dammer U, Danilowicz C, Davenport R J, De Duve C, Dekker N H, Deng H, Discher D E, Dohoney K M, Douarche F, Eisenberg E, Engel A, Essevaz-Roulet B, Evans D J, Evans E, Evans E, Evans E, Evans E, Evans E, F Ritort, Fain B, Fernandez J M, Fernandez J M, Fernandez J M, Finer J T, Finkelstein A V, Finzi L, Fisher M E, Florin E L, Flyvbjerg H, Forde N R, Forkey J N, Frank-Kamentskii M D, Frechet J M, Fritz J, Fréchet J M J, Gallavotti G, Garces-Chavez V, Garcia-Manyes S, Gelles J, Gelles J, Gelles J, Gergely C, Gerland U, Gerland U, Gerland U, Gestland R F, Goel A, Goel A, Gordon M P, Gore J, Gore J, Gosse C, Grange W, Green N H, Grier D G, Gross D H E, Ha T, Ha T, Hafner J H, Hanggi P, Hanke A, Hanley W, Hansen J C, Haran G, Harlepp S, Herschlag D, Higgs P G, Hill T L, Hill T L, Hinterdorfer P, Howard J, Hummer G, Hummer G, Hwa T, Hyeon C, Inoue A, Isralewitz B, Jarzynski C, Jarzynski C, Jarzynski C, Jarzynski C, Jensen M O, Jeruzalmi D, Junier I Ritort F, Jülicher F, Kafri Y, Katritch V, Kawakami M, Keller D, Keller D, Kellermayer M S K, Kellermayer M S, Kim H D, Kindt J, Kitamura K, Klimov D K, Klug A, Konrad M W, Kosikov K M, Kosztin I, Kramers H A, Kukowska-Latallo J F, Kunze K-K, Kurchan J, Kühner F, Ladoux B, Lang M J, Lang M J, Law R, Lebowitz J L, Lebrun A, Lee G U, Lee G U, Leger J F, Leuba S H, Leuva S H, Lhua R C, Li P T X Bustamante C Tinoco I, Liphardt J, Liu F, Lu H, Léger J F, Maes C, Maes C, Maier B, Manosas M, Manosas M Wen J D Li P T X Smith S B Bustamante C Tinoco I Ritort F, Marko J, Marko J, Marko J F, Marszalek P E, Marszalek P E, Marszalek P E, Masaike T, Mathews D H, Mazonka O Jarzynski C, McGurn A R, Merkel R, Min W, Moffitt J R, Molloy J E, Moy V T, Muller D J, Munoz V, Müller D J, Müller M, Müller M, Nayashima M, Nelson D R, Nguyen T T Grossberg A Y Shklovskii B I Holm C Kekicheff P Podgornik R, Noji H, Noy A, Oberhauser A F, Onoa B, Onoa B, Onuchic J N, Oono Y, Orland H, Orlandini E, Orphanides G, Paci E, Pagnani A, Pan J, Pant K, Park S, Pauling L, Perret E, Peyrard M, Phillips W D, Poirier M G, Poland D, Poland D, Purohit P K, Qian H, Qu X, Rief M, Rief M, Rief M, Rief M, Rief M, Rief M, Ritort F, Ritort F, Ritort F, Ritort F, Ros R, Rouzina I, Rouzina I, Rubinstein M, Saleh O A, Sarkar A, Schiessel H, Schiessel H, Schlierf M, Schroeder R, Schumakovitch I, Schurr J M, Schwesinger F, Seifert U, Sellers J R, Shaevitz J W, Smith B L, Smith D E, Smith S B, Soong R K, Sosnick T R, Speck T, Spudich A, Strick T, Strick T R, Strick T R, Strick T R, Strunz T, Svoboda K, Tanaka H, Thirumalai D, Thurmond K B, Tinoco I, Tinoco I, Tinoco I, Tinoco I, Tinoco I, Treiber D K, Treiber D K, Trepagnier E H, Tsallis C, Uemura S, Uptain S M, Valpuesta J M, Vanzi F, Veigel C, Veigel C, Visscher K, Vologodskii A, Wang M D, Wang M D, Wartell R M, Watson J D, Watson J D, Wen J D Manosas M Li P T X Smith S B Bustamante C Ritort F Tinoco I, Wenner J R, Widom J, Wiita A P, Wilkins M H F, Williams M C, Williams M C, Williams M C, Williams P M, Williams P M, Wood R H, Woodcock C L, Wuite G J L, Xie Z, Yager T D, Yang G, Yasuda R, Yasuda R, Yildiz A, Yildiz A, Yin H, Zandi R, Zarrinkar P, Zhou H, Zhuang X, Zuckermann D M, Zuker M, Zwanzig R W   +351 more
core   +1 more source

A Versatile Microfluidic Extrusion‐Based Hydrogel Platform for Self‐Organization and Long‐Term Maintenance of Engineered 3D Lymphatic Endothelium

Advanced Healthcare Materials, EarlyView.
Microfluidic coaxial extrusion generates size‐controlled 3D lymphatic tubes from primary human dermal lymphatic endothelial cells in a defined four‐component matrix. These engineered vessels self‐organize into stable lymphatic endothelium, maintain selective macromolecular permeability for 30 days, and enable direct comparison with blood endothelial ...
Elsa Mazari‐Arrighi, Adeline Boyreau, Laura Chaillot, Wilfried Souleyreau, Laetitia Andrique, Pierre‐Olivier Guichet, Thomas Mathivet, Andreas Bikfalvi, Pierre Nassoy   +8 more
wiley   +1 more source

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

Mechanically Programmable DNA Hydrogel Microparticles for 3D Cellular Systems

Advanced Materials, EarlyView.
DNA hydrogel microparticles are designed to exhibit controllable viscoelasticity and stiffness across three orders of magnitude from 30Pa$30 \,\mathrm{Pa}$ to 6.5kPa$6.5 \,\mathrm{kPa}$. They are uptaken into fibroblast spheroids where they are actively remodeled by cellular forces depending on their mechanical properties.
Tobias Walther, Eleni Dalaka, Gotthold Fläschner, Manuel Gómez‐González, Ilia Platzman, Sadaf Pashapour, Michelle Emmert, Pere Roca‐Cusachs, Xavier Trepat, Kerstin Göpfrich   +9 more
wiley   +1 more source

Cell Adhesion by Design: Engineering Tissue Culture Scaffolds With Adhesion Cues

Advanced Materials Interfaces, EarlyView.
ABSTRACT In scaffold‐based tissue engineering, the matrix should provide adequate adhesion cues for cell attachment, spreading, and function. Given the multitude of adhesion receptors and the diversity of scaffolds, there are many approaches to render scaffolds adhesive, even though they are not all equivalent.
Dalia Dranseike, Dhananjay V. Deshmukh, Mark W. Tibbitt, Céline Labouesse   +3 more
wiley   +1 more source