Surpassing the Path-Limited Resolution of a Fourier Transform Spectrometer with Frequency Combs
, 2015 Fourier transform spectroscopy based on incoherent light sources is a well-established tool in research fields from molecular spectroscopy and atmospheric monitoring to material science and biophysics.
Fermann, Martin E. +10 more
core +3 more sources
Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion. [PDF]
, 2012 The molecular underpinnings of synaptic vesicle fusion for fast neurotransmitter release are still unclear. Here, we used a single vesicle-vesicle system with reconstituted SNARE and synaptotagmin-1 proteoliposomes to decipher the temporal sequence of ...
Brunger, Axel T +13 more
core +1 more source
Data-driven enzyme immobilisation: a case study using DNA to immobilise galactose oxidase
Engineering Biology, 2020 Biocatalysis has the potential to enable green chemistry. New methods of enzyme immobilisation will be required to improve enzyme stability, product purification, and compatibility of different enzymes in the same reaction conditions.
Wolfgang Ott +4 more
doaj +1 more source
Universal protein fluctuations in populations of microorganisms
, 2012 The copy number of any protein fluctuates among cells in a population; characterizing and understanding these fluctuations is a fundamental problem in biophysics.
Braun, Erez +7 more
core +1 more source
Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta. [PDF]
, 2013 Amyloid protein aggregates are associated with dozens of devastating diseases including Alzheimer's, Parkinson's, ALS, and diabetes type 2. While structure-based discovery of compounds has been effective in combating numerous infectious and metabolic ...
Eisenberg, David S +6 more
core +1 more source
iScienceSummary: Transient anoxia causes amnesia and neuronal death. This is attributed to enhanced glutamate release and modeled as anoxia-induced long-term potentiation (aLTP).
Han-Ying Wang +6 more
doaj +1 more source
Deciphering the Gene Regulatory Landscape Encoded in DNA Biophysical Features
iScience, 2019 Summary: Gene regulation in higher organisms involves a sophisticated interplay between genetic and epigenetic mechanisms. Despite advances, the logic in selective usage of certain genomic regions as regulatory elements remains unclear. Here we show that
Abhijeet Pataskar +5 more
doaj +1 more source
Distinct RPA domains promote recruitment and the helicase-nuclease activities of Dna2
Nature Communications, 2021 An enzymatic ensemble including Dna2 functions in DNA end resection; the function of the single-stranded DNA binding protein RPA in this complex has been underappreciated.
Ananya Acharya +6 more
doaj +1 more source
How far can stochastic and deterministic views be reconciled?
, 2012 In this short note, we try to provide the reader with a brief pedagogical account of some similarities and differences between stochastic and deterministic processes.
Bergé +7 more
core +3 more sources
An unfolded protein-induced conformational switch activates mammalian IRE1. [PDF]
, 2017 The unfolded protein response (UPR) adjusts the cell's protein folding capacity in the endoplasmic reticulum (ER) according to need. IRE1 is the most conserved UPR sensor in eukaryotic cells.
Acosta-Alvear, Diego +5 more
core +3 more sources