Results 31 to 40 of about 319,701 (282)

Structure of catalase determined by MicroED. [PDF]

, 2014
MicroED is a recently developed method that uses electron diffraction for structure determination from very small three-dimensional crystals of biological material.
Gonen, Tamir, Hattne, Johan, Nannenga, Brent L, Reyes, Francis E, Shi, Dan   +4 more
core   +1 more source

Protein cages as building blocks for superstructures

Engineering Biology, 2021
Proteins naturally self‐assemble to function. Protein cages result from the self‐assembly of multiple protein subunits that interact to form hollow symmetrical structures with functions that range from cargo storage to catalysis. Driven by self‐assembly,
Ruoxuan Sun, Sierin Lim
doaj   +1 more source

A novel N-terminal extension in mitochondrial TRAP1 serves as a thermal regulator of chaperone activity. [PDF]

, 2014
Hsp90 is a conserved chaperone that facilitates protein homeostasis. Our crystal structure of the mitochondrial Hsp90, TRAP1, revealed an extension of the N-terminal β-strand previously shown to cross between protomers in the closed state. In this study,
Agard, David A, Cooke, Roger, Elnatan, Daniel, Lavery, Laura A, Naber, Nariman, Partridge, James R   +5 more
core   +2 more sources

Structural snapshots of Xer recombination reveal activation by synaptic complex remodeling and DNA bending [PDF]

, 2016
Bacterial Xer site-specific recombinases play an essential genome maintenance role by unlinking chromosome multimers, but their mechanism of action has remained structurally uncharacterized. Here, we present two high-resolution structures of Helicobacter
Adams, Afonine, Aihara, Arnold, Aussel, Barre, Barre, Biswas, Blakely, Blakely, Blakely, Britton, Carnoy, Chen, Cortez, Das, Debowski, Debowski, Diagne, Dong, Emsley, Ennifar, Fischer, Gopaul, Gopaul, Grainge, Grindley, Guo, Guo, Hendricks, Holliday, Jayaram, Jo, Kabsch, Karaca, Keller, Kelley, Kim, Krissinel, Kuempel, Le Bourgeois, Lee, Leroux, Li, Luscombe, May, McCoy, Midonet, Nagy, Nolivos, Nunes-Düby, Page, Pargellis, Pettersen, Pérals, Rother, Serre, Steiner, Subramanya, Terwilliger, Turan, Val, Van Duyne, Van Duyne, van Zundert, Vonrhein, Yang, Yang, Yates, Yates, Zawadzki, Zheng   +71 more
core   +4 more sources

Surpassing the Path-Limited Resolution of a Fourier Transform Spectrometer with Frequency Combs

, 2015
Fourier transform spectroscopy based on incoherent light sources is a well-established tool in research fields from molecular spectroscopy and atmospheric monitoring to material science and biophysics.
Fermann, Martin E., Foltynowicz, Aleksandra, Jiang, Jie, Johansson, Alexandra C., Khodabakhsh, Amir, Kowzan, Grzegorz, Lee, Kevin F., Maslowski, Piotr, Mills, Andrew A., Mohr, Christian, Rutkowski, Lucile   +10 more
core   +3 more sources

Data-driven enzyme immobilisation: a case study using DNA to immobilise galactose oxidase

Engineering Biology, 2020
Biocatalysis has the potential to enable green chemistry. New methods of enzyme immobilisation will be required to improve enzyme stability, product purification, and compatibility of different enzymes in the same reaction conditions.
Wolfgang Ott, Alessandro Ceccarelli, Jack Manning, Nicholas J. Turner, Robert Oppenheimer   +4 more
doaj   +1 more source

Universal protein fluctuations in populations of microorganisms

, 2012
The copy number of any protein fluctuates among cells in a population; characterizing and understanding these fluctuations is a fundamental problem in biophysics.
Braun, Erez, Brenner, Naama, Elyahu, Noa, Libchaber, Albert, Moore, Lindsay, Salman, Hanna, Stolovicki, Elad, Tung, Chih-kuan   +7 more
core   +1 more source

Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta. [PDF]

, 2013
Amyloid protein aggregates are associated with dozens of devastating diseases including Alzheimer's, Parkinson's, ALS, and diabetes type 2. While structure-based discovery of compounds has been effective in combating numerous infectious and metabolic ...
Eisenberg, David S, Hughes, Michael P, Jiang, Lin, Landau, Meytal, Leibly, David, Liu, Cong, Zhao, Minglei   +6 more
core   +1 more source

Anoxia-induced hippocampal LTP is regeneratively produced by glutamate and nitric oxide from the neuro-glial-endothelial axis

iScience
Summary: Transient anoxia causes amnesia and neuronal death. This is attributed to enhanced glutamate release and modeled as anoxia-induced long-term potentiation (aLTP).
Han-Ying Wang, Hiroshi Takagi, Patrick N. Stoney, Anai Echeverria, Bernd Kuhn, Kuei-Sen Hsu, Tomoyuki Takahashi   +6 more
doaj   +1 more source

Distinct RPA domains promote recruitment and the helicase-nuclease activities of Dna2

Nature Communications, 2021
An enzymatic ensemble including Dna2 functions in DNA end resection; the function of the single-stranded DNA binding protein RPA in this complex has been underappreciated.
Ananya Acharya, Kristina Kasaciunaite, Martin Göse, Vera Kissling, Raphaël Guérois, Ralf Seidel, Petr Cejka   +6 more
doaj   +1 more source