Results 11 to 20 of about 318,972 (299)

Temporary serine protease inhibition and the role of SPINK2 in human bone marrow

iScience, 2023
Summary: Protease temporary inhibitors are true substrates that bind the catalytic site with high affinity but are slowly degraded, thus acting as inhibitor for a defined time window.
Vincenza Barresi, Virginia Di Bella, Luca Lo Nigro, Anna Provvidenza Privitera, Paola Bonaccorso, Chiara Scuderi, Daniele Filippo Condorelli   +6 more
doaj   +1 more source

Editorial on the Special Issue on Recent Advances of Molecular Machines and Molecular Robots

Micromachines, 2020
Molecular machines and molecular robots are a highly interdisciplinary research field including material science, chemistry, biotechnology, biophysics, soft matter physics, micro-electromechanical systems (MEMS), and computer science [...]
Masahiro Takinoue, Ryuji Kawano
doaj   +1 more source

Nanoparticles as elicitors and harvesters of economically important secondary metabolites in higher plants: A review

IET Nanobiotechnology, 2021
Nanoparticles possess some unique properties which improve their biochemical reactivity. Plants, due to their stationary nature, are constantly exposed to nanoparticles present in the environment, which act as abiotic stress agents at sub‐toxic ...
Sanchaita Lala
doaj   +1 more source

Molecular and cellular basis of hyperassembly and protein aggregation driven by a rare pathogenic mutation in DDX3X

iScience, 2021
Summary: Current studies estimate that 1–3% of females with unexplained intellectual disability (ID) present de novo splice site, nonsense, frameshift, or missense mutations in the DDX3X protein (DEAD-Box Helicase 3 X-Linked).
Matheus de Castro Fonseca, Juliana Ferreira de Oliveira, Bruno Henrique Silva Araujo, Camila Canateli, Paula Favoretti Vital do Prado, Dionísio Pedro Amorim Neto, Beatriz Pelegrini Bosque, Paulla Vieira Rodrigues, João Vitor Pereira de Godoy, Katiane Tostes, Helder Veras Ribeiro Filho, Andrey Fabricio Ziem Nascimento, Angela Saito, Celisa Caldana Costa Tonoli, Fernanda Aparecida Heleno Batista, Paulo Sergio Lopes de Oliveira, Ana Carolina Figueira, Silvia Souza da Costa, Ana Cristina Victorino Krepischi, Carla Rosenberg, Harry Westfahl, Jr., Antônio José Roque da Silva, Kleber Gomes Franchini   +22 more
doaj   +1 more source

Effects of noise and time delay on E2F's expression level in a bistable Rb‐E2F gene’s regulatory network

IET Systems Biology, 2021
The bistable Rb‐E2F gene regulatory network plays a central role in regulating cellular proliferation‐quiescence transition. Based on Gillespie's chemical Langevin method, the stochastic bistable Rb‐E2F gene’s regulatory network with time delays is ...
John Billy Kirunda, Lijian Yang, Lulu Lu, Ya Jia   +3 more
doaj   +1 more source

Biliproteins [PDF]

, 1981
Biliproteins, covalently bonded complexes of proteins and bile pigments, serve as light-harvesting pigments in photosynthesis and light-sensory pigments of photosynthetic organisms. Recent developments in the biochemistry and biophysics of these pigments
Scheer, Hugo
core   +1 more source

NEURONIC SYSTEM INSIDE NEURONS: MOLECULAR BIOLOGY AND BIOPHYSICS OF NEURONAL MICROTUBULES [PDF]

, 2004
Neurons are highly specialized cells that input, process, store and output information. Interneuronal communication is achieved in four basic ways: (i) Ca2+ evoked exocytosis with chemical neurotransmission, (ii) gap junction electrotonic coupling, (iii)
Georgiev, Danko, Glazebrook, James, Papaioanou, Stelios   +2 more
core   +1 more source

The Molecular Biophysics of Adaptation [PDF]

Biophysical Journal, 2020
From molecular conformations to mass migrations, adaptation is a defining feature of life that is found across time and length scales. Here, we present a theory-experiment dialogue examining how adaptive behavior is manifested at the molecular level in the context of transcriptional regulation in bacteria.
Chure, Griffin, Phillips, Rob
openaire   +2 more sources

Brown adipocytes can display a mammary basal myoepithelial cell phenotype in vivo [PDF]

, 2017
This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB13030000) and the CAS-Novonordisk Foundation, as well as grants from the ‘1000 talents’ recruitment program, and a ‘Great-wall professorship’ from ...
Jin, Wanzhu, Król, Elżbieta, Li, Baoguo, Li, Li, Li, Min, Li, Ting, Niu, Chaoqun, Speakman, John R., Wang, Guanlin   +8 more
core   +2 more sources

Gi/o protein-coupled receptor inhibition of beta-cell electrical excitability and insulin secretion depends on Na+/K+ ATPase activation

Nature Communications, 2022
Gi/o protein-coupled receptors (Gi/o-GPCRs) limit β-cell insulin secretion by decreasing Ca2+ entry; however, the underlying mechanism has not been identified. Here, the authors show that Gi/o-GPCRs hyperpolarize mouse and human β-cell membrane potential
Matthew T. Dickerson, Prasanna K. Dadi, Karolina E. Zaborska, Arya Y. Nakhe, Charles M. Schaub, Jordyn R. Dobson, Nicole M. Wright, Joshua C. Lynch, Claire F. Scott, Logan D. Robinson, David A. Jacobson   +10 more
doaj   +1 more source