Results 31 to 40 of about 318,972 (299)
Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta. [PDF]
, 2013 Amyloid protein aggregates are associated with dozens of devastating diseases including Alzheimer's, Parkinson's, ALS, and diabetes type 2. While structure-based discovery of compounds has been effective in combating numerous infectious and metabolic ...
Eisenberg, David S +6 more
core +1 more source
Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction. [PDF]
, 2020 The AAA protein Msp1 extracts mislocalized tail-anchored membrane proteins and targets them for degradation, thus maintaining proper cell organization.
Myasnikov, Alexander +3 more
core +3 more sources
ATP and large signaling metabolites flux through caspase-activated Pannexin 1 channels
eLife, 2021 Pannexin 1 (Panx1) is a membrane channel implicated in numerous physiological and pathophysiological processes via its ability to support release of ATP and other cellular metabolites for local intercellular signaling. However, to date, there has been no
Adishesh K Narahari +14 more
doaj +1 more source
TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching. [PDF]
, 2015 The AAA+ family ATPase TRIP13 is a key regulator of meiotic recombination and the spindle assembly checkpoint, acting on signaling proteins of the conserved HORMA domain family.
Corbett, Kevin D +5 more
core +2 more sources
Role of Membrane Biophysics in Alzheimer's - related cell pathways
Frontiers in Neuroscience, 2015 Cellular membrane alterations are commonly observed in many diseases, including Alzheimer’s disease (AD). Membrane biophysical properties, such as membrane molecular order, membrane fluidity, organization of lipid rafts, and adhesion between membrane and
Donghui eZhu +5 more
doaj +1 more source
Structure of catalase determined by MicroED. [PDF]
, 2014 MicroED is a recently developed method that uses electron diffraction for structure determination from very small three-dimensional crystals of biological material.
Gonen, Tamir +4 more
core +1 more source
Expanding the scale of molecular biophysics [PDF]
Physical Biology, 2016 Here, I argue that some of the secrets of complex biological function rely on assemblies of many heterogeneous proteins that together enable sophisticated sensing and actuating processes. Evolution seems to delight in making these structures and in continually elaborating upon their capabilities.
openaire +2 more sources
Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs. [PDF]
, 2020 Cation-chloride-cotransporters (CCCs) catalyze transport of Cl- with K+ and/or Na+across cellular membranes. CCCs play roles in cellular volume regulation, neural development and function, audition, regulation of blood pressure, and renal function.
Brohawn, Stephen Graf +2 more
core +2 more sources
Universal protein fluctuations in populations of microorganisms
, 2012 The copy number of any protein fluctuates among cells in a population; characterizing and understanding these fluctuations is a fundamental problem in biophysics.
Braun, Erez +7 more
core +1 more source
iScienceSummary: Transient anoxia causes amnesia and neuronal death. This is attributed to enhanced glutamate release and modeled as anoxia-induced long-term potentiation (aLTP).
Han-Ying Wang +6 more
doaj +1 more source