Results 21 to 30 of about 3,587,617 (298)

Molecular Dynamics Simulations: Advances and Applications

Molecules, 2022
Molecular dynamics (MD) simulations have led to great advances in many scientific disciplines, such as chemical physics, materials science, and biophysics [...]
Hugo A. L. Filipe, Luís M. S. Loura
doaj   +1 more source

Temporary serine protease inhibition and the role of SPINK2 in human bone marrow

iScience, 2023
Summary: Protease temporary inhibitors are true substrates that bind the catalytic site with high affinity but are slowly degraded, thus acting as inhibitor for a defined time window.
Vincenza Barresi, Virginia Di Bella, Luca Lo Nigro, Anna Provvidenza Privitera, Paola Bonaccorso, Chiara Scuderi, Daniele Filippo Condorelli   +6 more
doaj   +1 more source

Electrostatics in Computational Biophysics and Its Implications for Disease Effects

, 2022
This review outlines the role of electrostatics in computational molecular biophysics and its implication in altering wild-type characteristics of biological macromolecules, and thus the contribution of electrostatics to disease mechanisms.
Sun, Shengjie, Li, Lin, Shengjie Sun, Lin Li, Emil Alexov, Alexov, Emil, Poudel, Pitambar, Pitambar Poudel   +7 more
core   +1 more source

Influence of Cupric (Cu2+) Ions on the Iron Oxidation Mechanism by DNA-Binding Protein from Starved Cells (Dps) from Marinobacter nauticus [PDF]

, 2023
Funding Information: This work was financed by national funds from the Fundação para a Ciência e a Tecnologia (FCT-MCTES), I.P., in the scope of the project UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences–UCIBIO and LA/P/0140/2020 ...
João P. L. Guerra, Tavares, Pedro, Daniela Penas, Penas, Daniela, Pedro Tavares, Alice S. Pereira, Pereira, Alice S., Guerra, João P.L.   +7 more
core   +1 more source

Molecular and cellular basis of hyperassembly and protein aggregation driven by a rare pathogenic mutation in DDX3X

iScience, 2021
Summary: Current studies estimate that 1–3% of females with unexplained intellectual disability (ID) present de novo splice site, nonsense, frameshift, or missense mutations in the DDX3X protein (DEAD-Box Helicase 3 X-Linked).
Matheus de Castro Fonseca, Juliana Ferreira de Oliveira, Bruno Henrique Silva Araujo, Camila Canateli, Paula Favoretti Vital do Prado, Dionísio Pedro Amorim Neto, Beatriz Pelegrini Bosque, Paulla Vieira Rodrigues, João Vitor Pereira de Godoy, Katiane Tostes, Helder Veras Ribeiro Filho, Andrey Fabricio Ziem Nascimento, Angela Saito, Celisa Caldana Costa Tonoli, Fernanda Aparecida Heleno Batista, Paulo Sergio Lopes de Oliveira, Ana Carolina Figueira, Silvia Souza da Costa, Ana Cristina Victorino Krepischi, Carla Rosenberg, Harry Westfahl, Jr., Antônio José Roque da Silva, Kleber Gomes Franchini   +22 more
doaj   +1 more source

Nanoparticles as elicitors and harvesters of economically important secondary metabolites in higher plants: A review

IET Nanobiotechnology, 2021
Nanoparticles possess some unique properties which improve their biochemical reactivity. Plants, due to their stationary nature, are constantly exposed to nanoparticles present in the environment, which act as abiotic stress agents at sub‐toxic ...
Sanchaita Lala
doaj   +1 more source

The Molecular Biophysics of Adaptation [PDF]

Biophysical Journal, 2020
From molecular conformations to mass migrations, adaptation is a defining feature of life that is found across time and length scales. Here, we present a theory-experiment dialogue examining how adaptive behavior is manifested at the molecular level in the context of transcriptional regulation in bacteria.
Chure, Griffin, Phillips, Rob
openaire   +2 more sources

Effects of noise and time delay on E2F's expression level in a bistable Rb‐E2F gene’s regulatory network

IET Systems Biology, 2021
The bistable Rb‐E2F gene regulatory network plays a central role in regulating cellular proliferation‐quiescence transition. Based on Gillespie's chemical Langevin method, the stochastic bistable Rb‐E2F gene’s regulatory network with time delays is ...
John Billy Kirunda, Lijian Yang, Lulu Lu, Ya Jia   +3 more
doaj   +1 more source

Biophysics [PDF]

, 2012
Biophysics is a vast cross-disciplinary subject encompassing the fields of biology, physics and computational biology etc in microbes, plants, animals and human being.

core   +1 more source

Role of quantum chemical calculations in molecular biophysics with a historical perspective [PDF]

, 2009
We discuss how the basic principles of quantum chemistry and quantum mechanics can be and have been applied to a variety of problems in molecular biophysics. First, the historical development of quantum concepts in biophysics is discussed.
Karl Jalkanen (23319343), A. Kukushkin (23370220)   +1 more
core   +2 more sources