Results 21 to 30 of about 191,889 (301)

Electrostatics in Computational Biophysics and Its Implications for Disease Effects [PDF]

, 2022
This review outlines the role of electrostatics in computational molecular biophysics and its implication in altering wild-type characteristics of biological macromolecules, and thus the contribution of electrostatics to disease mechanisms.
Sun, Shengjie, Li, Lin, Shengjie Sun, Lin Li, Emil Alexov, Alexov, Emil, Poudel, Pitambar, Pitambar Poudel   +7 more
core   +1 more source

Label-free protocol to quantify protein affinity using isothermal titration calorimetry and bio-layer interferometry of a human eIF5-mimic protein

STAR Protocols, 2022
Summary: eIF5-mimic protein (5MP) controls translation through its interaction with eukaryotic translation initiation factor (eIF) 2 and eIF3 and alters non-AUG translation rates for oncogenes in cancer and repeat expansions in neurodegenerative disease.
Chingakham Ranjit Singh, Rahul Jaiswal, Carlos R. Escalante, Katsura Asano   +3 more
doaj   +1 more source

Optimising protein synthesis in cell‐free systems, a review

Engineering Biology, 2021
Over the last decades, cell‐free systems have been extensively used for in vitro protein expression. A vast range of protocols and cellular sources varying from prokaryotes and eukaryotes are now available for cell‐free technology.
Angelo C. Batista, Paul Soudier, Manish Kushwaha, Jean‐Loup Faulon   +3 more
doaj   +1 more source

Molecular Dynamics Simulations: Advances and Applications

Molecules, 2022
Molecular dynamics (MD) simulations have led to great advances in many scientific disciplines, such as chemical physics, materials science, and biophysics [...]
Hugo A. L. Filipe, Luís M. S. Loura
doaj   +1 more source

Temporary serine protease inhibition and the role of SPINK2 in human bone marrow

iScience, 2023
Summary: Protease temporary inhibitors are true substrates that bind the catalytic site with high affinity but are slowly degraded, thus acting as inhibitor for a defined time window.
Vincenza Barresi, Virginia Di Bella, Luca Lo Nigro, Anna Provvidenza Privitera, Paola Bonaccorso, Chiara Scuderi, Daniele Filippo Condorelli   +6 more
doaj   +1 more source

Influence of Cupric (Cu2+) Ions on the Iron Oxidation Mechanism by DNA-Binding Protein from Starved Cells (Dps) from Marinobacter nauticus [PDF]

, 2023
Funding Information: This work was financed by national funds from the Fundação para a Ciência e a Tecnologia (FCT-MCTES), I.P., in the scope of the project UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences–UCIBIO and LA/P/0140/2020 ...
João P. L. Guerra, Tavares, Pedro, Daniela Penas, Penas, Daniela, Pedro Tavares, Alice S. Pereira, Pereira, Alice S., Guerra, João P.L.   +7 more
core   +1 more source

Editorial on the Special Issue on Recent Advances of Molecular Machines and Molecular Robots

Micromachines, 2020
Molecular machines and molecular robots are a highly interdisciplinary research field including material science, chemistry, biotechnology, biophysics, soft matter physics, micro-electromechanical systems (MEMS), and computer science [...]
Masahiro Takinoue, Ryuji Kawano
doaj   +1 more source

Nanoparticles as elicitors and harvesters of economically important secondary metabolites in higher plants: A review

IET Nanobiotechnology, 2021
Nanoparticles possess some unique properties which improve their biochemical reactivity. Plants, due to their stationary nature, are constantly exposed to nanoparticles present in the environment, which act as abiotic stress agents at sub‐toxic ...
Sanchaita Lala
doaj   +1 more source

Molecular and cellular basis of hyperassembly and protein aggregation driven by a rare pathogenic mutation in DDX3X

iScience, 2021
Summary: Current studies estimate that 1–3% of females with unexplained intellectual disability (ID) present de novo splice site, nonsense, frameshift, or missense mutations in the DDX3X protein (DEAD-Box Helicase 3 X-Linked).
Matheus de Castro Fonseca, Juliana Ferreira de Oliveira, Bruno Henrique Silva Araujo, Camila Canateli, Paula Favoretti Vital do Prado, Dionísio Pedro Amorim Neto, Beatriz Pelegrini Bosque, Paulla Vieira Rodrigues, João Vitor Pereira de Godoy, Katiane Tostes, Helder Veras Ribeiro Filho, Andrey Fabricio Ziem Nascimento, Angela Saito, Celisa Caldana Costa Tonoli, Fernanda Aparecida Heleno Batista, Paulo Sergio Lopes de Oliveira, Ana Carolina Figueira, Silvia Souza da Costa, Ana Cristina Victorino Krepischi, Carla Rosenberg, Harry Westfahl, Jr., Antônio José Roque da Silva, Kleber Gomes Franchini   +22 more
doaj   +1 more source

Effects of noise and time delay on E2F's expression level in a bistable Rb‐E2F gene’s regulatory network

IET Systems Biology, 2021
The bistable Rb‐E2F gene regulatory network plays a central role in regulating cellular proliferation‐quiescence transition. Based on Gillespie's chemical Langevin method, the stochastic bistable Rb‐E2F gene’s regulatory network with time delays is ...
John Billy Kirunda, Lijian Yang, Lulu Lu, Ya Jia   +3 more
doaj   +1 more source