Results 41 to 50 of about 315,729 (282)

A Membrane-Bound Biosensor Visualizes Shear Stress-Induced Inhomogeneous Alteration of Cell Membrane Tension

iScience, 2018
Summary: Cell membrane is the first medium from where a cell senses and responds to external stress stimuli. Exploring the tension changes in cell membrane will help us to understand intracellular force transmission.
Wang Li, Xinlei Yu, Fei Xie, Baohong Zhang, Shuai Shao, Chunyang Geng, Aziz ur Rehman Aziz, Xiaoling Liao, Bo Liu   +8 more
doaj   +1 more source

Proof phenomenon as a function of the phenomenology of proving [PDF]

, 2015
Kurt Gödel wrote (1964, p. 272), after he had read Husserl, that the notion of objectivity raises a question: “the question of the objective existence of the objects of mathematical intuition (which, incidentally, is an exact replica of the question of ...
Hipólito, Inês
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Advances in Terahertz Biophysics and Chemistry

Research
As terahertz (THz) science and technology continue to advance, THz biophysics and chemistry have emerged as a pivotal interface, linking molecular-scale insights with transformative innovations in biological, physical, and chemical sciences.
Zhi Zhu, Tianqi Wang, Huayan Yang, Junquan Zhu, Joseph S. Francisco, Chunlei Wang   +5 more
doaj   +1 more source

Mechanistic modelling of tyrosine recombination reveals key parameters determining the performance of a CAR T cell switching circuit

Engineering Biology, 2020
Inducible genetic switches based on tyrosine recombinase-based DNA excision are a promising platform for the regulation and control of chimeric antigen receptor (CAR) T cell activity in cancer immunotherapy. These switches exploit the increased stability
Jack E. Bowyer, Deboki Chakravarti, Wilson W. Wong, Declan G. Bates   +3 more
doaj   +1 more source

The effects of pH on the self-association of phycobiliprotein from Anacystis nidulans R₂ [PDF]

, 1988
Call number: LD2668 .T4 BICH 1988 V55Master of ScienceBiochemistry and Molecular Biophysics Interdepartmental ...
Vijayalakshmi, V.
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Oxidative modifications and structural changes of human serum albumin in response to air dielectric barrier discharge plasma

High Voltage, 2021
In this work, the air dielectric barrier discharge plasma was applied to a model of protein human serum albumin to explore plasma‐mediated protein damage from a biomolecular perspective.
Siqi Peng, Liyang Zhang, Dongheyu Zhang, Yuntao Guo, Xinxin Wang, Qun Zhou, Haiyun Luo   +6 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source