Results 161 to 170 of about 227,395 (295)

The Hsp90 molecular chaperone governs client proteins by targeting intrinsically disordered regions. [PDF]

Mol Cell, 2023
Kolhe JA, Babu NL, Freeman BC.
europepmc   +1 more source

Mosaic activation of the zebrafish hsp70l heat shock promoter: Implications for interpreting transgenes

Developmental Dynamics, EarlyView.
Abstract Background The promoters and enhancers of heat shock genes, such as the 1.5‐kb promoter of the zebrafish hsp70l gene, are valuable tools for temporal activation of transgenes. It has been widely purported that heat shock treatments result in ubiquitous expression of hsp70l‐driven transgenes.
Jong‐Su Park, Xiangyun Wei
wiley   +1 more source

New allosteric modulators of molecular chaperone TRAP1 from the integration of computational biology, medicinal chemistry, and biophysics. [PDF]

Cell Stress Chaperones
Guarra F, Komarov D, Ciamarone A, Torielli L, Previtali V, Margaroli N, Romeo E, La Spina M, Sbuelz F, Laquatra C, Veronesi M, Lolicato M, Arrigoni C, Moroni E, Serapian SA, Girotto S, Rasola A, Colombo G.   +17 more
europepmc   +1 more source

Secretopathies emerge as a new class of neurocristopathies

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient embryonic population of cells that give rise to a wide range of structures, including craniofacial cartilage and bone, peripheral neurons and glia, as well as components of the cardiac outflow tract, among others.
Amanda Teixeira, Cassandra Millet‐Boureima, Joshua A. Moore, Loydie A. Jerome‐Majewska   +3 more
wiley   +1 more source

Deletion of Core 1 β3GalT-specific molecular chaperone (Cosmc) in murine intestinal epithelia leads to major alterations in glycocalyx and tumorigenesis. [PDF]

J Biol Chem
Ju T, Wang Y, Nishio H, Kudelka MR, Sun X, Wang J, Zeng J, Song L, Akkas G, Adsay V, Parkos CA, Cummings RD.   +11 more
europepmc   +1 more source

The Molecular Chaperone Mechanism of the C-Terminal Domain of Large-Size Subunit Catalases. [PDF]

Antioxidants (Basel), 2023
Nava-Ramírez T, Gutiérrez-Terrazas S, Hansberg W.   +2 more
europepmc   +1 more source

Effects of fenfluramine and sigma‐1‐dependent pharmacological and genetic modulation in a mouse kindling model

Epilepsia, EarlyView.
Abstract Objective Sigma‐1 is a chaperone protein that serves as a key homeostatic regulator, implicated in neuronal excitability and seizure control. Positive allosteric modulators offer a use‐dependent means to enhance Sigma‐1 activity, potentially with favorable tolerability compared to direct agonists.
Eva‐Lotta von Rüden, Verena Buchecker, Amelie Wagner, Victoria M. Stocker, Liga Zvejniece, Heidrun Potschka   +5 more
wiley   +1 more source

Molecular chaperone effects on recombinant yield and binding characteristics of an ABA-specific scFv in <i>Escherichia coli</i>. [PDF]

Front Bioeng Biotechnol
Chen S, Shan B, Luo Y, Mo G, Rasheed U, Lv L, Yang X, Lu Q.   +7 more
europepmc   +1 more source

The yeast molecular chaperone, Hsp104, influences transthyretin aggregate formation. [PDF]

Front Mol Neurosci, 2022
Knier AS, Davis EE, Buchholz HE, Dorweiler JE, Flannagan LE, Manogaran AL.   +5 more
europepmc   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source