Results 41 to 50 of about 140,081 (117)

Prediction of recombinant Mycobacterium tuberculosis α-crystallin oligomer chaperone activity using polynomial graphs [version 1; peer review: 2 approved]

F1000Research, 2018
Background: Mycobacterial α-crystallin (Acr) is a chaperone that prevents misfolding of proteins when Mycobacterium tuberculosis is found in a latent form in the host tissue. Methods: Using insulin as a model substrate and utilizing polynomial graphs, we
Gautam Krishnan, Utpal Roy
doaj   +1 more source

Regulation of Protein Transport Pathways by the Cytosolic Hsp90s

Biomolecules, 2022
The highly conserved molecular chaperone heat shock protein 90 (Hsp90) is well-known for maintaining metastable proteins and mediating various aspects of intracellular protein dynamics. Intriguingly, high-throughput interactome studies suggest that Hsp90
Anna G. Mankovich, Brian C. Freeman
doaj   +1 more source

Targeting the Hsp90-Cdc37-client protein interaction to disrupt Hsp90 chaperone machinery

Journal of Hematology & Oncology, 2018
Heat shock protein 90 (Hsp90) is a critical molecular chaperone protein that regulates the folding, maturation, and stability of a wide variety of proteins.
Ting Li, Hu-Lin Jiang, Yun-Guang Tong, Jin-Jian Lu   +3 more
doaj   +1 more source

Hsp90/Cdc37 Chaperone/co-chaperone complex, a novel junction anticancer target elucidated by the mode of action of herbal drug Withaferin A

BMC Bioinformatics, 2011
Background HSPs (Heat shock proteins) are highly conserved ubiquitous proteins among species which are involved in maintaining appropriate folding and conformation of other proteins and are thus referred to as molecular chaperones.
Bisaria Virendra S, Bhasme Divya, Pratik Piyush, Agrawal Vibhuti, Shandilya Ashutosh, Grover Abhinav, Sundar Durai   +6 more
doaj   +1 more source

Hsp70- and Hsp90-mediated proteasomal degradation underlies TPIsugarkill pathogenesis in Drosophila

Neurobiology of Disease, 2010
Triosephosphate isomerase (TPI) deficiency is a severe glycolytic enzymopathy that causes progressive locomotor impairment and neurodegeneration, susceptibility to infection, and premature death. The recessive missense TPIsugarkill mutation in Drosophila
Stacy L. Hrizo, Michael J. Palladino
doaj   +1 more source

Advances in the structures, mechanisms and targeting of molecular chaperones

Signal Transduction and Targeted Therapy
Molecular chaperones, a class of complex client regulatory systems, play significant roles in the prevention of protein misfolding and abnormal aggregation, the modulation of protein homeostasis, and the protection of cells from damage under constantly ...
Jinying Gu, Yanyi He, Chenxi He, Qiuyue Zhang, Qifei Huang, Shangjun Bai, Ruoning Wang, Qidong You, Lei Wang   +8 more
doaj   +1 more source

Embracing diversity: Post-translational modifications, the chaperone code, and the emergence of new chaperone entities

Cell Stress & Chaperones
Dr Len Neckers played a pioneering role in establishing that HSP90 is regulated by post-translational modifications (PTMs), fundamentally reshaping how molecular chaperones are understood. This insight laid the foundation for what has become known as the
Chander S. Digwal, Shujuan Wang, Gabriela Chiosis   +2 more
doaj   +1 more source

Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1

eLife, 2019
Loss of proteostasis and cellular senescence are key hallmarks of aging, but direct cause-effect relationships are not well understood. We show that most yeast cells arrest in G1 before death with low nuclear levels of Cln3, a key G1 cyclin extremely ...
David F Moreno, Kirsten Jenkins, Sandrine Morlot, Gilles Charvin, Attila Csikasz-Nagy, Martí Aldea   +5 more
doaj   +1 more source

Peptide substrate identification for yeast Hsp40 Ydj1 by screening the phage display library

Biological Procedures Online, 2004
We have identified a peptide substrate for molecular chaperone Hsp40 Ydj1 by utilizing the combination of phage display library screening and isothemol titration calirimetry (ITC).
Li Jingzhi, Sha Bingdong
doaj   +1 more source

Redox‐Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis

Advanced Science
Reactive oxygen species (ROS) are pivotal signals that trigger the transition from seed dormancy to germination, yet the molecular link between ROS and transcriptional regulation has remained unclear. Here, we uncover a redox‐dependent mechanism focusing
Yunying Wang, Xiaofeng Fang
doaj   +1 more source